Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5D7I

Structure of human MR1-Ac-6-FP in complex with human MAIT M33.64 TCR

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002376	biological_process	immune system process
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0032092	biological_process	positive regulation of protein binding
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1900121	biological_process	negative regulation of receptor binding
D	1900122	biological_process	positive regulation of receptor binding
D	1904434	biological_process	positive regulation of ferrous iron binding
D	1904437	biological_process	positive regulation of transferrin receptor binding
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue PRO A 301

Chain	Residue
A	TYR254
A	GLN268
A	VAL269

site_id	AC2
Number of Residues	13
Details	binding site for residue 30W A 302

Chain	Residue
A	ILE96
A	TRP156
A	HOH412
A	HOH432
A	HOH473
A	HOH493
G	TYR95
A	TYR7
A	ARG9
A	LYS43
A	TYR62
A	TRP69
A	ARG94

site_id	AC3
Number of Residues	7
Details	binding site for residue GOL A 303

Chain	Residue
A	ASP57
A	ARG61
A	HOH410
A	HOH498
G	ASN94
G	GLN96
H	HOH427

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 304

Chain	Residue
A	GLU160
A	ALA163
A	TRP164
A	ARG167
A	HOH484
G	SER27
G	GLY28
G	SER93

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL B 101

Chain	Residue
B	GLN8
B	VAL9
B	LYS94
B	TRP95
B	ASP96
B	GOL102
B	HOH214
C	ASP133
C	ASN134

site_id	AC6
Number of Residues	8
Details	binding site for residue GOL B 102

Chain	Residue
B	PRO5
B	LYS6
B	ILE7
B	LYS91
B	VAL93
B	GOL101
C	ASP133
C	ASN134

site_id	AC7
Number of Residues	2
Details	binding site for residue PRO C 301

Chain	Residue
C	GLN268
C	VAL269

site_id	AC8
Number of Residues	12
Details	binding site for residue 30W C 302

Chain	Residue
C	TYR7
C	ARG9
C	LYS43
C	TYR62
C	TRP69
C	ARG94
C	ILE96
C	TRP156
C	HOH440
C	HOH476
C	HOH491
E	TYR95

site_id	AC9
Number of Residues	8
Details	binding site for residue GOL C 303

Chain	Residue
C	GLU160
C	ALA163
C	TRP164
C	ARG167
C	HOH402
E	SER27
E	GLY28
E	SER93

site_id	AD1
Number of Residues	9
Details	binding site for residue GOL H 301

Chain	Residue
G	PHE33
G	HOH309
H	TYR33
H	ALA96
H	GLY98
H	ASN99
H	GLY101
H	GLU102
H	HOH401

site_id	AD2
Number of Residues	9
Details	binding site for residue GOL H 302

Chain	Residue
G	GLY40
H	GLU107
H	GLY108
H	ARG110
H	HIS154
H	HOH404
H	HOH418
H	HOH471
H	HOH530

site_id	AD3
Number of Residues	5
Details	binding site for residue GOL H 303

Chain	Residue
H	ARG36
H	ARG44
H	SER84
H	HOH529
H	HOH563

site_id	AD4
Number of Residues	4
Details	binding site for residue GOL E 301

Chain	Residue
E	GLU193
E	ASP194
E	THR195
E	HOH497

site_id	AD5
Number of Residues	8
Details	binding site for residue GOL F 301

Chain	Residue
F	ALA96
F	GLY98
F	ASN99
F	GLY101
F	HOH401
F	HOH447
E	HOH431
F	TYR33

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YSCHVEH

Chain	Residue	Details
A	TYR254-HIS260
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN2
C	GLN153
D	GLN2
A	ARG94
A	TYR152
A	GLN153
C	ARG9
C	SER24
C	ARG94
C	TYR152

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE1
D	ILE1

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS19
D	LYS58
D	LYS91
D	LYS94
B	LYS41
B	LYS48
B	LYS58
B	LYS91
B	LYS94
D	LYS19
D	LYS41
D	LYS48

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)