5D6Y
Crystal structure of double tudor domain of human lysine demethylase KDM4A complexed with histone H3K23me3
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| a | M3L23 | |
| D | ASP945 | |
| D | TRP967 | |
| D | TYR973 | |
| E | ASP945 | |
| E | TRP967 | |
| E | TYR973 | |
| F | ASP945 | |
| F | TRP967 | |
| F | TYR973 | |
| b | M3L23 | |
| c | M3L23 | |
| d | M3L23 | |
| B | TRP967 | |
| B | TYR973 | |
| C | ASP945 | |
| C | TRP967 | |
| C | TYR973 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | MOD_RES: Citrulline => ECO:0000269|PubMed:16567635 |
| Chain | Residue | Details |
| a | ARG26 | |
| b | ARG26 | |
| c | ARG26 | |
| d | ARG26 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16627869, ECO:0000269|PubMed:17194708 |
| Chain | Residue | Details |
| a | LYS27 | |
| b | LYS27 | |
| c | LYS27 | |
| d | LYS27 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:15684425, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| Chain | Residue | Details |
| a | SER28 | |
| b | SER28 | |
| c | SER28 | |
| d | SER28 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| site_id | MCSA2 |
| Number of Residues | |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| site_id | MCSA3 |
| Number of Residues | |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| site_id | MCSA4 |
| Number of Residues | |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| site_id | MCSA5 |
| Number of Residues | |
| Details | M-CSA 370 |
| Chain | Residue | Details |
| site_id | MCSA6 |
| Number of Residues | |
| Details | M-CSA 370 |
| Chain | Residue | Details |
