5D6R
Acetolactate Synthase from Klebsiella pneumoniae in Complex with Mechanism-Based Inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003984 | molecular_function | acetolactate synthase activity |
| B | 0005948 | cellular_component | acetolactate synthase complex |
| B | 0009097 | biological_process | isoleucine biosynthetic process |
| B | 0009099 | biological_process | L-valine biosynthetic process |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019752 | biological_process | carboxylic acid metabolic process |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0034077 | biological_process | butanediol metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| M | 0000287 | molecular_function | magnesium ion binding |
| M | 0003824 | molecular_function | catalytic activity |
| M | 0003984 | molecular_function | acetolactate synthase activity |
| M | 0005948 | cellular_component | acetolactate synthase complex |
| M | 0009097 | biological_process | isoleucine biosynthetic process |
| M | 0009099 | biological_process | L-valine biosynthetic process |
| M | 0016740 | molecular_function | transferase activity |
| M | 0019752 | biological_process | carboxylic acid metabolic process |
| M | 0030976 | molecular_function | thiamine pyrophosphate binding |
| M | 0034077 | biological_process | butanediol metabolic process |
| M | 0046872 | molecular_function | metal ion binding |
| M | 0050660 | molecular_function | flavin adenine dinucleotide binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 601 |
| Chain | Residue |
| B | ASP447 |
| B | ASP474 |
| B | GLY476 |
| B | EN0605 |
| B | HOH705 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue MG B 602 |
| Chain | Residue |
| B | SER129 |
| B | THR132 |
| B | HOH776 |
| B | HOH816 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 603 |
| Chain | Residue |
| B | ARG69 |
| B | GLN220 |
| B | PRO221 |
| B | HOH747 |
| B | HOH784 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue PO4 B 604 |
| Chain | Residue |
| B | PHE256 |
| B | GLY258 |
| B | ARG259 |
| B | GLN266 |
| B | ARG352 |
| B | ALA402 |
| B | ARG403 |
| B | LEU405 |
| B | TYR406 |
| B | HOH708 |
| site_id | AC5 |
| Number of Residues | 27 |
| Details | binding site for residue EN0 B 605 |
| Chain | Residue |
| B | PRO33 |
| B | ALA35 |
| B | GLU57 |
| B | PRO83 |
| B | ASN87 |
| B | GLN120 |
| B | MET394 |
| B | GLY395 |
| B | SER396 |
| B | PHE397 |
| B | GLN420 |
| B | MET422 |
| B | GLY446 |
| B | ASP447 |
| B | GLY448 |
| B | GLY449 |
| B | ASP474 |
| B | GLY476 |
| B | TYR477 |
| B | ASN478 |
| B | MET479 |
| B | VAL480 |
| B | TYR543 |
| B | MG601 |
| B | HOH705 |
| B | HOH715 |
| B | HOH761 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue MG M 601 |
| Chain | Residue |
| M | ASP447 |
| M | ASP474 |
| M | GLY476 |
| M | EN0604 |
| M | HOH708 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | binding site for residue MG M 602 |
| Chain | Residue |
| M | SER129 |
| M | THR132 |
| M | HOH733 |
| M | HOH833 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue PO4 M 603 |
| Chain | Residue |
| M | GLY258 |
| M | ARG259 |
| M | GLN266 |
| M | ARG352 |
| M | LEU405 |
| M | TYR406 |
| M | HOH711 |
| site_id | AC9 |
| Number of Residues | 26 |
| Details | binding site for residue EN0 M 604 |
| Chain | Residue |
| M | PRO33 |
| M | ALA35 |
| M | GLU57 |
| M | THR80 |
| M | ASN87 |
| M | MET394 |
| M | GLY395 |
| M | SER396 |
| M | PHE397 |
| M | GLN420 |
| M | MET422 |
| M | GLY446 |
| M | ASP447 |
| M | GLY448 |
| M | GLY449 |
| M | ASP474 |
| M | GLY476 |
| M | TYR477 |
| M | ASN478 |
| M | MET479 |
| M | VAL480 |
| M | GLN483 |
| M | TYR543 |
| M | MG601 |
| M | HOH708 |
| M | HOH731 |
Functional Information from PROSITE/UniProt
| site_id | PS00187 |
| Number of Residues | 20 |
| Details | TPP_ENZYMES Thiamine pyrophosphate enzymes signature. IGawlvnPerkvVsVsGDGG |
| Chain | Residue | Details |
| B | ILE430-GLY449 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 84 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
