5CUY

Crystal structure of Trypanosoma brucei Vacuolar Soluble Pyrophosphatases in apo form

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004427	molecular_function	inorganic diphosphate phosphatase activity
A	0005509	molecular_function	calcium ion binding
A	0005737	cellular_component	cytoplasm
A	0006796	biological_process	phosphate-containing compound metabolic process
A	0008270	molecular_function	zinc ion binding
A	0016462	molecular_function	pyrophosphatase activity
A	0016787	molecular_function	hydrolase activity
A	0020022	cellular_component	acidocalcisome
A	0046872	molecular_function	metal ion binding
B	0000287	molecular_function	magnesium ion binding
B	0004427	molecular_function	inorganic diphosphate phosphatase activity
B	0005509	molecular_function	calcium ion binding
B	0005737	cellular_component	cytoplasm
B	0006796	biological_process	phosphate-containing compound metabolic process
B	0008270	molecular_function	zinc ion binding
B	0016462	molecular_function	pyrophosphatase activity
B	0016787	molecular_function	hydrolase activity
B	0020022	cellular_component	acidocalcisome
B	0046872	molecular_function	metal ion binding
C	0000287	molecular_function	magnesium ion binding
C	0004427	molecular_function	inorganic diphosphate phosphatase activity
C	0005509	molecular_function	calcium ion binding
C	0005737	cellular_component	cytoplasm
C	0006796	biological_process	phosphate-containing compound metabolic process
C	0008270	molecular_function	zinc ion binding
C	0016462	molecular_function	pyrophosphatase activity
C	0016787	molecular_function	hydrolase activity
C	0020022	cellular_component	acidocalcisome
C	0046872	molecular_function	metal ion binding
D	0000287	molecular_function	magnesium ion binding
D	0004427	molecular_function	inorganic diphosphate phosphatase activity
D	0005509	molecular_function	calcium ion binding
D	0005737	cellular_component	cytoplasm
D	0006796	biological_process	phosphate-containing compound metabolic process
D	0008270	molecular_function	zinc ion binding
D	0016462	molecular_function	pyrophosphatase activity
D	0016787	molecular_function	hydrolase activity
D	0020022	cellular_component	acidocalcisome
D	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue CIT A 901

Chain	Residue
A	ARG213
A	LYS215
A	THR219
A	MET221
A	ASN222
A	ARG223
A	LYS314
A	HIS336

---

site_id	AC2
Number of Residues	4
Details	binding site for residue MG A 902

Chain	Residue
A	PRO294
A	ASP296
A	ASP328
A	ASP291

---

site_id	AC3
Number of Residues	7
Details	binding site for residue CIT B 901

Chain	Residue
B	ARG213
B	LYS215
B	THR219
B	PRO220
B	ASN222
B	ARG223
B	HIS336

---

site_id	AC4
Number of Residues	6
Details	binding site for residue MG B 902

Chain	Residue
B	ASP296
B	ASP328
B	HOH1025
B	HOH1036
B	HOH1050
B	HOH1094

---

site_id	AC5
Number of Residues	10
Details	binding site for residue CIT C 901

Chain	Residue
C	ARG213
C	LYS215
C	THR219
C	PRO220
C	MET221
C	ASN222
C	ARG223
C	LYS314
C	HIS336
C	HOH1057

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MG C 902

Chain	Residue
C	ASP291
C	ASP296
C	ASP328
C	HOH1080

---

site_id	AC7
Number of Residues	10
Details	binding site for residue CIT D 901

Chain	Residue
D	ARG213
D	LYS215
D	THR219
D	PRO220
D	MET221
D	ASN222
D	ARG223
D	HIS336
D	HOH1017
D	HOH1075

---

site_id	AC8
Number of Residues	3
Details	binding site for residue MG D 902

Chain	Residue
D	ASP291
D	ASP296
D	ASP328

---

Functional Information from PROSITE/UniProt

site_id	PS00387
Number of Residues	7
Details	PPASE Inorganic pyrophosphatase signature. DNDPVDA

Chain	Residue	Details
A	ASP291-ALA297

---