5CSV

Crystal Structure of CK2alpha with Compound 6 bound

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004674	molecular_function	protein serine/threonine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ACT A 401

Chain	Residue
A	ARG80
A	ARG155
A	ASN189
A	HOH653

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site_id	AC2
Number of Residues	4
Details	binding site for residue ACT A 402

Chain	Residue
A	ASP103
A	ALA110
A	ARG280
A	HOH568

---

site_id	AC3
Number of Residues	9
Details	binding site for residue GAB A 403

Chain	Residue
A	VAL66
A	LYS68
A	PHE113
A	ILE174
A	ASP175
A	HOH501
A	HOH520
A	HOH544
A	VAL53

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	33
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGRGKYSEVFeAinitnnekvvvkilkpv.AAAK

Chain	Residue	Details
A	LEU45-LYS77

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ImHrDVKphNVMI

Chain	Residue	Details
A	ILE152-ILE164

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	285
Details	Domain: {"description":"Protein kinase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	5
Details	Region: {"description":"Interaction with beta subunit","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"description":"Proton acceptor"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	9
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---