5CSL
Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
A | 0004075 | molecular_function | biotin carboxylase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005739 | cellular_component | mitochondrion |
A | 0005783 | cellular_component | endoplasmic reticulum |
A | 0005789 | cellular_component | endoplasmic reticulum membrane |
A | 0005829 | cellular_component | cytosol |
A | 0006085 | biological_process | acetyl-CoA biosynthetic process |
A | 0006606 | biological_process | protein import into nucleus |
A | 0006633 | biological_process | fatty acid biosynthetic process |
A | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
A | 0016020 | cellular_component | membrane |
A | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
A | 0016874 | molecular_function | ligase activity |
A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0044281 | biological_process | small molecule metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 1905502 | molecular_function | acetyl-CoA binding |
A | 2001295 | biological_process | malonyl-CoA biosynthetic process |
B | 0003989 | molecular_function | acetyl-CoA carboxylase activity |
B | 0004075 | molecular_function | biotin carboxylase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005739 | cellular_component | mitochondrion |
B | 0005783 | cellular_component | endoplasmic reticulum |
B | 0005789 | cellular_component | endoplasmic reticulum membrane |
B | 0005829 | cellular_component | cytosol |
B | 0006085 | biological_process | acetyl-CoA biosynthetic process |
B | 0006606 | biological_process | protein import into nucleus |
B | 0006633 | biological_process | fatty acid biosynthetic process |
B | 0009317 | cellular_component | acetyl-CoA carboxylase complex |
B | 0016020 | cellular_component | membrane |
B | 0016743 | molecular_function | carboxyl- or carbamoyltransferase activity |
B | 0016874 | molecular_function | ligase activity |
B | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0044281 | biological_process | small molecule metabolic process |
B | 0046872 | molecular_function | metal ion binding |
B | 1905502 | molecular_function | acetyl-CoA binding |
B | 2001295 | biological_process | malonyl-CoA biosynthetic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 7 |
Details | binding site for residue BTI A 2301 |
Chain | Residue |
A | LYS735 |
A | LEU1756 |
A | THR1757 |
A | MET1765 |
B | PHE1956 |
B | GLY1998 |
B | VAL2024 |
site_id | AC2 |
Number of Residues | 4 |
Details | binding site for residue BTI A 2302 |
Chain | Residue |
A | GLY1958 |
B | ILE1762 |
A | PHE1956 |
A | SER1957 |
site_id | AC3 |
Number of Residues | 11 |
Details | binding site for residue COA A 2303 |
Chain | Residue |
A | ILE1593 |
A | SER1625 |
A | ALA1627 |
A | ARG1628 |
A | ILE1629 |
A | GLY1734 |
A | ILE1735 |
A | LEU1756 |
B | ILE2033 |
B | LYS2034 |
B | ARG2036 |
site_id | AC4 |
Number of Residues | 10 |
Details | binding site for residue COA B 2301 |
Chain | Residue |
A | LYS2034 |
B | ILE1593 |
B | SER1625 |
B | ALA1627 |
B | ARG1628 |
B | ILE1629 |
B | ARG1731 |
B | GLY1734 |
B | LEU1756 |
B | ASN1774 |
Functional Information from PROSITE/UniProt
site_id | PS00188 |
Number of Residues | 18 |
Details | BIOTIN Biotin-requiring enzymes attachment site. GQpYaeIeVMKMqmpLvS |
Chain | Residue | Details |
A | GLY725-SER742 |
site_id | PS00866 |
Number of Residues | 15 |
Details | CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPVMIKASeggGGkG |
Chain | Residue | Details |
A | PHE247-GLY261 |
site_id | PS00867 |
Number of Residues | 8 |
Details | CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. FLELNPRL |
Chain | Residue | Details |
A | PHE377-LEU384 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: ACT_SITE => ECO:0000250 |
Chain | Residue | Details |
A | ARG383 | |
B | ARG383 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00409 |
Chain | Residue | Details |
A | GLY256 | |
B | GLY256 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: BINDING => ECO:0000250 |
Chain | Residue | Details |
A | GLU365 | |
A | GLU379 | |
A | ASN381 | |
B | GLU365 | |
B | GLU379 | |
B | ASN381 |
site_id | SWS_FT_FI4 |
Number of Residues | 10 |
Details | BINDING: |
Chain | Residue | Details |
A | ALA1627 | |
B | ARG2036 | |
A | ARG1731 | |
A | GLY1998 | |
A | LYS2034 | |
A | ARG2036 | |
B | ALA1627 | |
B | ARG1731 | |
B | GLY1998 | |
B | LYS2034 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-biotinyllysine => ECO:0000250, ECO:0000255|PROSITE-ProRule:PRU01066 |
Chain | Residue | Details |
A | LYS735 | |
B | LYS735 |
site_id | SWS_FT_FI6 |
Number of Residues | 4 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER790 | |
A | SER1162 | |
B | SER790 | |
B | SER1162 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER1148 | |
B | SER1148 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:15665377, ECO:0007744|PubMed:17330950, ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
Chain | Residue | Details |
A | SER1157 | |
B | SER1157 |