Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5CS8

Crystal Structure of the first bromodomain of human BRD4 in complex with benzo[cd]indol-2(1H)-one ligand

Functional Information from PDB Data
site_idAC1
Number of Residues11
Detailsbinding site for residue EB8 A 201
ChainResidue
ATRP81
AHOH316
AHOH318
APHE83
AVAL87
ALEU92
AASP96
ALYS99
AASN140
AMET149
ANO3202

site_idAC2
Number of Residues9
Detailsbinding site for residue NO3 A 202
ChainResidue
ALYS55
APRO56
ALYS57
ATYR98
ALYS99
ALYS102
AASP145
AEB8201
AHOH325

site_idAC3
Number of Residues9
Detailsbinding site for residue NO3 A 203
ChainResidue
AHIS34
AHIS35
AHIS36
AHIS37
ALEU38
AVAL39
AGLN123
AILE126
AASN130

site_idAC4
Number of Residues5
Detailsbinding site for residue EDO A 204
ChainResidue
AILE100
AILE101
ALYS102
ATHR103
AASN135

site_idAC5
Number of Residues2
Detailsbinding site for residue EDO A 205
ChainResidue
AGLY108
AHOH304

site_idAC6
Number of Residues5
Detailsbinding site for residue EDO A 206
ChainResidue
ASER43
AASN54
AALA89
AHOH310
AHOH322

site_idAC7
Number of Residues7
Detailsbinding site for residue GOL A 207
ChainResidue
APRO46
APRO48
AARG58
APRO104
ATRP120
AASN121
AHOH305

site_idAC8
Number of Residues5
Detailsbinding site for residue GOL A 208
ChainResidue
AARG41
AGLY42
AASN54
AGLN78
AHOH302

site_idAC9
Number of Residues8
Detailsbinding site for residue GOL A 209
ChainResidue
ATYR65
AVAL69
ATYR137
AVAL147
AGLU151
ALYS160
AGLU163
AHOH317

Functional Information from PROSITE/UniProt
site_idPS00633
Number of Residues60
DetailsBROMODOMAIN_1 Bromodomain signature. AwpFqqpvDavklnlpDYYkiIktpMdmgtIkkrlenny..Ywnaqeciqdfnt.MftNCyiY
ChainResidueDetails
AALA80-TYR139

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsSITE: Acetylated histone binding => ECO:0000269|PubMed:22464331
ChainResidueDetails
AASN140

site_idSWS_FT_FI2
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS99

222926

PDB entries from 2024-07-24

PDB statisticsPDBj update infoContact PDBjnumon