5CRG
Human skeletal calsequestrin, D210G mutant high-calcium complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005790 | cellular_component | smooth endoplasmic reticulum |
| A | 0007519 | biological_process | skeletal muscle tissue development |
| A | 0014701 | cellular_component | junctional sarcoplasmic reticulum membrane |
| A | 0014802 | cellular_component | terminal cisterna |
| A | 0014804 | cellular_component | terminal cisterna lumen |
| A | 0014809 | biological_process | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| A | 0014870 | biological_process | response to muscle inactivity |
| A | 0014894 | biological_process | response to denervation involved in regulation of muscle adaptation |
| A | 0016529 | cellular_component | sarcoplasmic reticulum |
| A | 0030016 | cellular_component | myofibril |
| A | 0030018 | cellular_component | Z disc |
| A | 0030315 | cellular_component | T-tubule |
| A | 0031674 | cellular_component | I band |
| A | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
| A | 0033018 | cellular_component | sarcoplasmic reticulum lumen |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0045214 | biological_process | sarcomere organization |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051258 | biological_process | protein polymerization |
| A | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
| A | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| A | 1901341 | biological_process | positive regulation of store-operated calcium channel activity |
| A | 2001256 | biological_process | regulation of store-operated calcium entry |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005790 | cellular_component | smooth endoplasmic reticulum |
| B | 0007519 | biological_process | skeletal muscle tissue development |
| B | 0014701 | cellular_component | junctional sarcoplasmic reticulum membrane |
| B | 0014802 | cellular_component | terminal cisterna |
| B | 0014804 | cellular_component | terminal cisterna lumen |
| B | 0014809 | biological_process | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| B | 0014870 | biological_process | response to muscle inactivity |
| B | 0014894 | biological_process | response to denervation involved in regulation of muscle adaptation |
| B | 0016529 | cellular_component | sarcoplasmic reticulum |
| B | 0030016 | cellular_component | myofibril |
| B | 0030018 | cellular_component | Z disc |
| B | 0030315 | cellular_component | T-tubule |
| B | 0031674 | cellular_component | I band |
| B | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
| B | 0033018 | cellular_component | sarcoplasmic reticulum lumen |
| B | 0042383 | cellular_component | sarcolemma |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0045214 | biological_process | sarcomere organization |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051258 | biological_process | protein polymerization |
| B | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
| B | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| B | 1901341 | biological_process | positive regulation of store-operated calcium channel activity |
| B | 2001256 | biological_process | regulation of store-operated calcium entry |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005790 | cellular_component | smooth endoplasmic reticulum |
| C | 0007519 | biological_process | skeletal muscle tissue development |
| C | 0014701 | cellular_component | junctional sarcoplasmic reticulum membrane |
| C | 0014802 | cellular_component | terminal cisterna |
| C | 0014804 | cellular_component | terminal cisterna lumen |
| C | 0014809 | biological_process | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| C | 0014870 | biological_process | response to muscle inactivity |
| C | 0014894 | biological_process | response to denervation involved in regulation of muscle adaptation |
| C | 0016529 | cellular_component | sarcoplasmic reticulum |
| C | 0030016 | cellular_component | myofibril |
| C | 0030018 | cellular_component | Z disc |
| C | 0030315 | cellular_component | T-tubule |
| C | 0031674 | cellular_component | I band |
| C | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
| C | 0033018 | cellular_component | sarcoplasmic reticulum lumen |
| C | 0042383 | cellular_component | sarcolemma |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0045214 | biological_process | sarcomere organization |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051258 | biological_process | protein polymerization |
| C | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
| C | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| C | 1901341 | biological_process | positive regulation of store-operated calcium channel activity |
| C | 2001256 | biological_process | regulation of store-operated calcium entry |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005790 | cellular_component | smooth endoplasmic reticulum |
| D | 0007519 | biological_process | skeletal muscle tissue development |
| D | 0014701 | cellular_component | junctional sarcoplasmic reticulum membrane |
| D | 0014802 | cellular_component | terminal cisterna |
| D | 0014804 | cellular_component | terminal cisterna lumen |
| D | 0014809 | biological_process | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| D | 0014870 | biological_process | response to muscle inactivity |
| D | 0014894 | biological_process | response to denervation involved in regulation of muscle adaptation |
| D | 0016529 | cellular_component | sarcoplasmic reticulum |
| D | 0030016 | cellular_component | myofibril |
| D | 0030018 | cellular_component | Z disc |
| D | 0030315 | cellular_component | T-tubule |
| D | 0031674 | cellular_component | I band |
| D | 0033017 | cellular_component | sarcoplasmic reticulum membrane |
| D | 0033018 | cellular_component | sarcoplasmic reticulum lumen |
| D | 0042383 | cellular_component | sarcolemma |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0045214 | biological_process | sarcomere organization |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0051258 | biological_process | protein polymerization |
| D | 0051279 | biological_process | regulation of release of sequestered calcium ion into cytosol |
| D | 0051281 | biological_process | positive regulation of release of sequestered calcium ion into cytosol |
| D | 1901341 | biological_process | positive regulation of store-operated calcium channel activity |
| D | 2001256 | biological_process | regulation of store-operated calcium entry |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ASP13 |
| A | VAL15 |
| A | GLU55 |
| A | GLU59 |
| A | HOH796 |
| A | HOH932 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 402 |
| Chain | Residue |
| A | HOH769 |
| A | HOH846 |
| A | HOH893 |
| A | GLU199 |
| A | THR229 |
| A | THR277 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 403 |
| Chain | Residue |
| A | GLY210 |
| A | PRO212 |
| A | GLU217 |
| A | HOH652 |
| A | HOH716 |
| A | HOH957 |
| A | HOH970 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 404 |
| Chain | Residue |
| A | THR189 |
| A | HOH554 |
| A | HOH694 |
| A | HOH706 |
| A | HOH717 |
| A | HOH1008 |
| A | HOH1015 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 405 |
| Chain | Residue |
| A | ASP5 |
| A | PHE6 |
| A | GLU8 |
| A | HOH570 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 406 |
| Chain | Residue |
| A | GLU91 |
| A | GLU105 |
| A | ASP107 |
| A | GLU240 |
| A | HOH531 |
| A | HOH711 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 407 |
| Chain | Residue |
| A | GLU91 |
| A | ASP107 |
| A | GLU243 |
| A | HOH669 |
| A | HOH912 |
| A | HOH947 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 408 |
| Chain | Residue |
| A | ASP93 |
| A | ASP107 |
| A | HOH719 |
| A | HOH912 |
| A | HOH1143 |
| site_id | AC9 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 409 |
| Chain | Residue |
| A | ASP113 |
| A | HOH646 |
| A | HOH822 |
| A | HOH1054 |
| B | ASP113 |
| B | HOH503 |
| B | HOH557 |
| site_id | AD1 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 410 |
| Chain | Residue |
| A | GLU117 |
| A | HOH894 |
| A | HOH920 |
| A | HOH946 |
| B | ASP290 |
| B | HOH628 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 411 |
| Chain | Residue |
| A | ASP165 |
| A | HOH582 |
| A | HOH591 |
| A | HOH679 |
| A | HOH776 |
| A | HOH1094 |
| site_id | AD3 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 412 |
| Chain | Residue |
| A | GLU169 |
| A | GLU215 |
| A | HOH663 |
| A | HOH673 |
| A | HOH731 |
| A | HOH937 |
| A | HOH1029 |
| site_id | AD4 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 413 |
| Chain | Residue |
| A | PRO172 |
| A | HOH597 |
| A | HOH748 |
| A | HOH824 |
| A | HOH936 |
| A | HOH1011 |
| A | HOH1066 |
| site_id | AD5 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 414 |
| Chain | Residue |
| A | LYS301 |
| A | ASP304 |
| A | HOH787 |
| A | HOH896 |
| A | HOH975 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 415 |
| Chain | Residue |
| A | ASP321 |
| A | THR353 |
| A | HOH778 |
| A | HOH997 |
| site_id | AD7 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 416 |
| Chain | Residue |
| A | ASP332 |
| A | HOH850 |
| A | HOH917 |
| A | HOH919 |
| A | HOH923 |
| A | HOH1002 |
| A | HOH1131 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue CA A 417 |
| Chain | Residue |
| A | HOH873 |
| A | GLU344 |
| A | HOH701 |
| A | HOH851 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 418 |
| Chain | Residue |
| A | ASP290 |
| B | ASP121 |
| B | HOH548 |
| B | HOH553 |
| B | HOH654 |
| B | HOH722 |
| B | HOH926 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue CA A 419 |
| Chain | Residue |
| A | ASP259 |
| A | ASP261 |
| A | GLU330 |
| B | GLU128 |
| B | HOH882 |
| site_id | AE2 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 420 |
| Chain | Residue |
| A | ASP261 |
| A | GLU331 |
| A | HOH553 |
| B | GLU135 |
| B | HOH567 |
| B | HOH758 |
| site_id | AE3 |
| Number of Residues | 8 |
| Details | binding site for residue CA A 421 |
| Chain | Residue |
| A | ASP261 |
| A | GLU264 |
| A | GLU331 |
| A | HOH566 |
| A | HOH583 |
| A | HOH618 |
| B | GLU135 |
| B | HOH636 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 422 |
| Chain | Residue |
| A | ASP121 |
| A | HOH561 |
| A | HOH627 |
| A | HOH683 |
| A | HOH741 |
| B | ASP290 |
| B | HOH917 |
| site_id | AE5 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 423 |
| Chain | Residue |
| A | GLU128 |
| A | HOH592 |
| B | ASP259 |
| B | ASP261 |
| B | GLU330 |
| B | HOH501 |
| B | HOH546 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 424 |
| Chain | Residue |
| A | GLU135 |
| A | HOH593 |
| A | HOH695 |
| B | ASP261 |
| B | GLU331 |
| B | HOH520 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue CA A 425 |
| Chain | Residue |
| A | GLU135 |
| A | HOH547 |
| B | ASP261 |
| B | GLU264 |
| B | GLU331 |
| B | HOH529 |
| B | HOH789 |
| site_id | AE8 |
| Number of Residues | 6 |
| Details | binding site for residue CA A 426 |
| Chain | Residue |
| A | ASP290 |
| A | HOH705 |
| B | GLU117 |
| B | HOH695 |
| B | HOH791 |
| B | HOH896 |
| site_id | AE9 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| B | ASP13 |
| B | VAL15 |
| B | GLU55 |
| B | GLU59 |
| B | HOH735 |
| B | HOH902 |
| site_id | AF1 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 402 |
| Chain | Residue |
| B | GLU199 |
| B | THR229 |
| B | THR277 |
| B | HOH658 |
| B | HOH674 |
| B | HOH881 |
| site_id | AF2 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 403 |
| Chain | Residue |
| B | GLY210 |
| B | PRO212 |
| B | GLU217 |
| B | HOH825 |
| B | HOH853 |
| site_id | AF3 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 404 |
| Chain | Residue |
| B | THR189 |
| B | HOH566 |
| B | HOH635 |
| B | HOH671 |
| B | HOH721 |
| B | HOH909 |
| site_id | AF4 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 405 |
| Chain | Residue |
| A | HOH1076 |
| B | ASP332 |
| B | HOH753 |
| B | HOH786 |
| B | HOH805 |
| site_id | AF5 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 406 |
| Chain | Residue |
| B | ASP5 |
| B | PHE6 |
| B | GLU8 |
| B | HOH571 |
| B | HOH841 |
| B | HOH907 |
| site_id | AF6 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 407 |
| Chain | Residue |
| B | GLU91 |
| B | GLU105 |
| B | ASP107 |
| B | GLU240 |
| B | HOH625 |
| B | HOH645 |
| site_id | AF7 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 408 |
| Chain | Residue |
| B | GLU91 |
| B | ASP107 |
| B | GLU243 |
| B | HOH556 |
| B | HOH751 |
| B | HOH880 |
| site_id | AF8 |
| Number of Residues | 5 |
| Details | binding site for residue CA B 409 |
| Chain | Residue |
| B | ASP93 |
| B | ASP107 |
| B | HOH556 |
| B | HOH751 |
| B | HOH756 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue CA B 410 |
| Chain | Residue |
| B | GLU102 |
| B | GLU169 |
| B | HOH580 |
| B | HOH906 |
| site_id | AG1 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 411 |
| Chain | Residue |
| B | GLU169 |
| B | GLU215 |
| B | HOH779 |
| B | HOH783 |
| B | HOH897 |
| B | HOH906 |
| site_id | AG2 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 412 |
| Chain | Residue |
| B | ASP165 |
| B | HOH539 |
| B | HOH744 |
| B | HOH769 |
| B | HOH905 |
| B | HOH1043 |
| B | HOH1071 |
| site_id | AG3 |
| Number of Residues | 7 |
| Details | binding site for residue CA B 413 |
| Chain | Residue |
| B | PRO172 |
| B | HOH647 |
| B | HOH661 |
| B | HOH668 |
| B | HOH839 |
| B | HOH956 |
| B | HOH992 |
| site_id | AG4 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 414 |
| Chain | Residue |
| B | ASP245 |
| B | ASP247 |
| B | ILE249 |
| B | HOH697 |
| B | HOH921 |
| B | HOH952 |
| site_id | AG5 |
| Number of Residues | 6 |
| Details | binding site for residue CA B 415 |
| Chain | Residue |
| B | ASP321 |
| B | THR353 |
| B | HOH846 |
| B | HOH862 |
| B | HOH901 |
| B | HOH976 |
| site_id | AG6 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 401 |
| Chain | Residue |
| C | ASP13 |
| C | VAL15 |
| C | GLU55 |
| C | GLU59 |
| C | HOH905 |
| C | HOH989 |
| site_id | AG7 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 402 |
| Chain | Residue |
| C | GLU199 |
| C | THR229 |
| C | THR277 |
| C | HOH677 |
| C | HOH736 |
| C | HOH896 |
| site_id | AG8 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 403 |
| Chain | Residue |
| C | GLY210 |
| C | PRO212 |
| C | GLU217 |
| C | HOH773 |
| C | HOH888 |
| C | HOH921 |
| C | HOH972 |
| site_id | AG9 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 404 |
| Chain | Residue |
| C | THR189 |
| C | HOH599 |
| C | HOH618 |
| C | HOH623 |
| C | HOH793 |
| C | HOH1001 |
| C | HOH1017 |
| site_id | AH1 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 405 |
| Chain | Residue |
| C | ASP5 |
| C | PHE6 |
| C | GLU8 |
| C | HOH524 |
| site_id | AH2 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 406 |
| Chain | Residue |
| C | GLU91 |
| C | GLU105 |
| C | ASP107 |
| C | GLU240 |
| C | HOH513 |
| C | HOH730 |
| site_id | AH3 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 407 |
| Chain | Residue |
| C | GLU91 |
| C | ASP107 |
| C | GLU243 |
| C | HOH662 |
| C | HOH899 |
| C | HOH940 |
| site_id | AH4 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 408 |
| Chain | Residue |
| C | ASP93 |
| C | ASP107 |
| C | HOH658 |
| C | HOH899 |
| site_id | AH5 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 409 |
| Chain | Residue |
| C | ASP113 |
| C | HOH723 |
| C | HOH890 |
| C | HOH985 |
| D | ASP113 |
| D | HOH784 |
| site_id | AH6 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 410 |
| Chain | Residue |
| C | GLU117 |
| C | HOH822 |
| C | HOH882 |
| C | HOH973 |
| D | ASP290 |
| D | HOH648 |
| site_id | AH7 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 411 |
| Chain | Residue |
| C | ASP121 |
| C | HOH518 |
| C | HOH597 |
| C | HOH656 |
| C | HOH960 |
| D | ASP290 |
| D | HOH544 |
| site_id | AH8 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 412 |
| Chain | Residue |
| C | ASP165 |
| C | HOH541 |
| C | HOH733 |
| C | HOH759 |
| C | HOH1148 |
| site_id | AH9 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 413 |
| Chain | Residue |
| C | GLU169 |
| C | GLU215 |
| C | HOH504 |
| C | HOH588 |
| C | HOH802 |
| C | HOH977 |
| C | HOH995 |
| site_id | AI1 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 414 |
| Chain | Residue |
| C | PRO172 |
| C | HOH671 |
| C | HOH705 |
| C | HOH829 |
| C | HOH833 |
| C | HOH1043 |
| C | HOH1060 |
| site_id | AI2 |
| Number of Residues | 5 |
| Details | binding site for residue CA C 415 |
| Chain | Residue |
| C | LYS301 |
| C | ASP304 |
| C | HOH783 |
| C | HOH804 |
| C | HOH943 |
| site_id | AI3 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 416 |
| Chain | Residue |
| C | ASP321 |
| C | THR353 |
| C | HOH894 |
| C | HOH917 |
| C | HOH942 |
| C | HOH1020 |
| C | HOH1027 |
| site_id | AI4 |
| Number of Residues | 4 |
| Details | binding site for residue CA C 417 |
| Chain | Residue |
| C | ASP332 |
| C | HOH808 |
| C | HOH820 |
| C | HOH933 |
| site_id | AI5 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 418 |
| Chain | Residue |
| C | GLU344 |
| C | HOH582 |
| C | HOH694 |
| C | HOH763 |
| C | HOH912 |
| C | HOH1076 |
| site_id | AI6 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 419 |
| Chain | Residue |
| C | ASP290 |
| D | ASP121 |
| D | HOH625 |
| D | HOH630 |
| D | HOH709 |
| D | HOH824 |
| D | HOH889 |
| site_id | AI7 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 420 |
| Chain | Residue |
| C | ASP259 |
| C | ASP261 |
| C | GLU330 |
| C | HOH572 |
| D | GLU128 |
| D | HOH696 |
| site_id | AI8 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 421 |
| Chain | Residue |
| C | ASP261 |
| C | GLU331 |
| C | HOH572 |
| D | GLU135 |
| D | HOH570 |
| D | HOH657 |
| site_id | AI9 |
| Number of Residues | 8 |
| Details | binding site for residue CA C 422 |
| Chain | Residue |
| C | ASP261 |
| C | GLU264 |
| C | GLU331 |
| C | HOH626 |
| C | HOH637 |
| C | HOH776 |
| D | GLU135 |
| D | HOH677 |
| site_id | AJ1 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 423 |
| Chain | Residue |
| C | GLU128 |
| C | HOH717 |
| D | ASP259 |
| D | ASP261 |
| D | GLU330 |
| D | HOH529 |
| site_id | AJ2 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 424 |
| Chain | Residue |
| C | GLU135 |
| C | CA425 |
| C | HOH551 |
| C | HOH743 |
| D | ASP261 |
| D | GLU331 |
| D | HOH634 |
| site_id | AJ3 |
| Number of Residues | 7 |
| Details | binding site for residue CA C 425 |
| Chain | Residue |
| C | GLU135 |
| C | CA424 |
| C | HOH615 |
| D | ASP261 |
| D | GLU264 |
| D | GLU331 |
| D | HOH524 |
| site_id | AJ4 |
| Number of Residues | 6 |
| Details | binding site for residue CA C 426 |
| Chain | Residue |
| C | ASP290 |
| C | HOH655 |
| C | HOH974 |
| D | GLU117 |
| D | HOH895 |
| D | HOH902 |
| site_id | AJ5 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 401 |
| Chain | Residue |
| D | ASP13 |
| D | VAL15 |
| D | GLU55 |
| D | GLU59 |
| D | HOH637 |
| D | HOH913 |
| site_id | AJ6 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 402 |
| Chain | Residue |
| D | GLU199 |
| D | THR229 |
| D | THR277 |
| D | HOH622 |
| D | HOH838 |
| D | HOH877 |
| site_id | AJ7 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 403 |
| Chain | Residue |
| D | GLY210 |
| D | PRO212 |
| D | GLU217 |
| D | HOH772 |
| D | HOH875 |
| site_id | AJ8 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 404 |
| Chain | Residue |
| D | THR189 |
| D | HOH569 |
| D | HOH646 |
| D | HOH664 |
| D | HOH722 |
| D | HOH932 |
| site_id | AJ9 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 405 |
| Chain | Residue |
| D | ASP5 |
| D | PHE6 |
| D | GLU8 |
| D | HOH542 |
| D | HOH893 |
| site_id | AK1 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 406 |
| Chain | Residue |
| D | GLU91 |
| D | GLU105 |
| D | ASP107 |
| D | GLU240 |
| D | HOH531 |
| D | HOH655 |
| site_id | AK2 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 407 |
| Chain | Residue |
| D | GLU91 |
| D | ASP107 |
| D | GLU243 |
| D | HOH584 |
| D | HOH833 |
| D | HOH878 |
| site_id | AK3 |
| Number of Residues | 4 |
| Details | binding site for residue CA D 408 |
| Chain | Residue |
| D | ASP93 |
| D | ASP107 |
| D | HOH615 |
| D | HOH833 |
| site_id | AK4 |
| Number of Residues | 5 |
| Details | binding site for residue CA D 409 |
| Chain | Residue |
| D | ASP165 |
| D | HOH718 |
| D | HOH795 |
| D | HOH841 |
| D | HOH1084 |
| site_id | AK5 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 410 |
| Chain | Residue |
| D | GLU102 |
| D | GLU169 |
| D | CA411 |
| D | HOH853 |
| D | HOH896 |
| D | HOH959 |
| site_id | AK6 |
| Number of Residues | 7 |
| Details | binding site for residue CA D 411 |
| Chain | Residue |
| D | GLU169 |
| D | GLU215 |
| D | CA410 |
| D | HOH826 |
| D | HOH850 |
| D | HOH896 |
| D | HOH959 |
| site_id | AK7 |
| Number of Residues | 7 |
| Details | binding site for residue CA D 412 |
| Chain | Residue |
| D | PRO172 |
| D | HOH581 |
| D | HOH582 |
| D | HOH681 |
| D | HOH756 |
| D | HOH948 |
| D | HOH983 |
| site_id | AK8 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 413 |
| Chain | Residue |
| D | ASP321 |
| D | THR353 |
| D | HOH629 |
| D | HOH740 |
| D | HOH891 |
| D | HOH1006 |
| site_id | AK9 |
| Number of Residues | 6 |
| Details | binding site for residue CA D 414 |
| Chain | Residue |
| C | HOH868 |
| C | HOH1000 |
| D | ASP332 |
| D | HOH822 |
| D | HOH857 |
| D | HOH886 |
| site_id | AL1 |
| Number of Residues | 8 |
| Details | binding site for residue CA D 415 |
| Chain | Residue |
| D | GLU337 |
| D | GLU340 |
| D | HOH506 |
| D | HOH643 |
| D | HOH759 |
| D | HOH922 |
| D | HOH935 |
| D | HOH1005 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P19633","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P19633","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"UniProtKB","id":"P19633","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
