5COR

X-RAY STRUCTURE OF MACROPHAGE INFLAMMATORY PROTEIN-1 ALPHA (CCL3) N-TERMINAL-SWITCH POLYMER

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region
A	0006955	biological_process	immune response
A	0008009	molecular_function	chemokine activity
B	0005576	cellular_component	extracellular region
B	0006955	biological_process	immune response
B	0008009	molecular_function	chemokine activity
C	0005576	cellular_component	extracellular region
C	0006955	biological_process	immune response
C	0008009	molecular_function	chemokine activity
D	0005576	cellular_component	extracellular region
D	0006955	biological_process	immune response
D	0008009	molecular_function	chemokine activity
E	0005576	cellular_component	extracellular region
E	0006955	biological_process	immune response
E	0008009	molecular_function	chemokine activity
F	0005576	cellular_component	extracellular region
F	0006955	biological_process	immune response
F	0008009	molecular_function	chemokine activity
G	0005576	cellular_component	extracellular region
G	0006955	biological_process	immune response
G	0008009	molecular_function	chemokine activity
H	0005576	cellular_component	extracellular region
H	0006955	biological_process	immune response
H	0008009	molecular_function	chemokine activity
I	0005576	cellular_component	extracellular region
I	0006955	biological_process	immune response
I	0008009	molecular_function	chemokine activity
J	0005576	cellular_component	extracellular region
J	0006955	biological_process	immune response
J	0008009	molecular_function	chemokine activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue HEZ A 101

Chain	Residue
A	TYR28
A	GLU30
A	HEZ102
I	VAL50

---

site_id	AC2
Number of Residues	5
Details	binding site for residue HEZ A 102

Chain	Residue
A	HEZ101
I	SER47
I	ARG48
I	GLN49
J	THR7

---

site_id	AC3
Number of Residues	2
Details	binding site for residue HEZ B 101

Chain	Residue
J	TYR28
J	GLU30

---

site_id	AC4
Number of Residues	6
Details	binding site for residue HEZ C 101

Chain	Residue
A	ARG46
C	GLN22
C	ALA26
C	TYR62
C	ASP65
C	LEU66

---

site_id	AC5
Number of Residues	4
Details	binding site for residue HEZ E 101

Chain	Residue
E	GLN19
E	PRO21
E	GLN22
E	TYR62

---

site_id	AC6
Number of Residues	5
Details	binding site for residue HEZ E 102

Chain	Residue
E	ARG18
E	ARG48
E	HOH206
G	TYR28
G	GLU30

---

site_id	AC7
Number of Residues	4
Details	binding site for residue HEZ E 103

Chain	Residue
C	ARG18
E	TYR28
E	GLU30
E	HOH216

---

site_id	AC8
Number of Residues	2
Details	binding site for residue HEZ F 101

Chain	Residue
F	TYR28
F	GLU30

---

site_id	AC9
Number of Residues	3
Details	binding site for residue ACT F 102

Chain	Residue
F	GLN19
F	GLU57
F	LYS61

---

site_id	AD1
Number of Residues	6
Details	binding site for residue HEZ H 101

Chain	Residue
H	GLN19
H	GLN22
H	ASN23
H	TYR62
I	SER55
I	GLN60

---

site_id	AD2
Number of Residues	2
Details	binding site for residue HEZ H 102

Chain	Residue
H	TYR28
H	GLU30

---

site_id	AD3
Number of Residues	3
Details	binding site for residue ACT I 101

Chain	Residue
H	PRO8
I	SER2
I	LEU3

---

site_id	AD4
Number of Residues	2
Details	binding site for residue ACT I 102

Chain	Residue
I	GLN19
I	LYS61

---

Functional Information from PROSITE/UniProt

site_id	PS00472
Number of Residues	42
Details	SMALL_CYTOKINES_CC Small cytokines (intercrine/chemokine) C-C subfamily signature. CCFsytsrq..IpqnfIadYfetssq..Cskp.GVIFltkrsrqv.CA

Chain	Residue	Details
A	CYS11-ALA52

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	30
Details	SITE: Involved in GAG binding

Chain	Residue	Details
A	ARG18
D	ARG18
D	ARG46
D	ARG48
E	ARG18
E	ARG46
E	ARG48
F	ARG18
F	ARG46
F	ARG48
G	ARG18
A	ARG46
G	ARG46
G	ARG48
H	ARG18
H	ARG46
H	ARG48
I	ARG18
I	ARG46
I	ARG48
J	ARG18
J	ARG46
A	ARG48
J	ARG48
B	ARG18
B	ARG46
B	ARG48
C	ARG18
C	ARG46
C	ARG48

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