5CJU
Isobutyryl-CoA mutase fused with bound adenosylcobalamin, GDP, Mg (holo-IcmF/GDP), and substrate n-butyryl-coenzyme A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0004494 | molecular_function | methylmalonyl-CoA mutase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006637 | biological_process | acyl-CoA metabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0016853 | molecular_function | isomerase activity |
| A | 0016866 | molecular_function | intramolecular transferase activity |
| A | 0031419 | molecular_function | cobalamin binding |
| A | 0034784 | molecular_function | pivalyl-CoA mutase activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047727 | molecular_function | isobutyryl-CoA mutase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0004494 | molecular_function | methylmalonyl-CoA mutase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006637 | biological_process | acyl-CoA metabolic process |
| B | 0016787 | molecular_function | hydrolase activity |
| B | 0016853 | molecular_function | isomerase activity |
| B | 0016866 | molecular_function | intramolecular transferase activity |
| B | 0031419 | molecular_function | cobalamin binding |
| B | 0034784 | molecular_function | pivalyl-CoA mutase activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047727 | molecular_function | isobutyryl-CoA mutase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 36 |
| Details | binding site for residue B12 A 1101 |
| Chain | Residue |
| A | PHE36 |
| A | GLY88 |
| A | GLY114 |
| A | GLY116 |
| A | VAL118 |
| A | TYR136 |
| A | SER137 |
| A | PRO138 |
| A | ALA626 |
| A | PHE627 |
| A | LEU632 |
| A | GLY38 |
| A | TYR633 |
| A | SER650 |
| A | GLY741 |
| A | GLN742 |
| A | THR744 |
| A | HIS780 |
| A | GLU783 |
| A | ALA784 |
| A | GLY868 |
| A | ARG869 |
| A | HIS39 |
| A | LEU871 |
| A | GLU905 |
| A | ALA906 |
| A | THR908 |
| A | HIS993 |
| A | 5AD1102 |
| A | BCO1103 |
| A | ASP40 |
| A | ALA41 |
| A | SER42 |
| A | MET46 |
| A | TYR86 |
| A | GLN87 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | binding site for residue 5AD A 1102 |
| Chain | Residue |
| A | PHE598 |
| A | GLY600 |
| A | TYR779 |
| A | GLN865 |
| A | GLY868 |
| A | HIS899 |
| A | ASN901 |
| A | GLU905 |
| A | THR909 |
| A | PRO910 |
| A | B121101 |
| A | BCO1103 |
| site_id | AC3 |
| Number of Residues | 24 |
| Details | binding site for residue BCO A 1103 |
| Chain | Residue |
| A | PHE585 |
| A | PHE587 |
| A | ARG589 |
| A | ARG596 |
| A | PHE598 |
| A | ARG622 |
| A | SER624 |
| A | SER677 |
| A | THR679 |
| A | ARG728 |
| A | THR730 |
| A | GLN732 |
| A | GLN742 |
| A | TYR772 |
| A | HIS780 |
| A | SER821 |
| A | PHE823 |
| A | ARG856 |
| A | LYS861 |
| A | HIS863 |
| A | GLN865 |
| A | SER897 |
| A | B121101 |
| A | 5AD1102 |
| site_id | AC4 |
| Number of Residues | 17 |
| Details | binding site for residue GDP A 1104 |
| Chain | Residue |
| A | GLY219 |
| A | ALA220 |
| A | GLY221 |
| A | LYS222 |
| A | SER223 |
| A | SER224 |
| A | ARG265 |
| A | GLU310 |
| A | ASN357 |
| A | LYS358 |
| A | ASP360 |
| A | GLN395 |
| A | ALA396 |
| A | SER397 |
| A | GLU973 |
| A | ASN1092 |
| A | MG1105 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1105 |
| Chain | Residue |
| A | SER223 |
| A | ASP262 |
| A | GLU310 |
| A | GDP1104 |
| A | MG1106 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1106 |
| Chain | Residue |
| A | MG1105 |
| A | ILE248 |
| A | ASP249 |
| A | ASP262 |
| A | GLU310 |
| A | THR311 |
| site_id | AC7 |
| Number of Residues | 19 |
| Details | binding site for residue B12 B 1101 |
| Chain | Residue |
| B | GLY38 |
| B | HIS39 |
| B | ASP40 |
| B | ALA41 |
| B | SER42 |
| B | MET46 |
| B | ALA82 |
| B | TYR86 |
| B | GLN87 |
| B | GLY114 |
| B | GLY116 |
| B | TYR136 |
| B | SER137 |
| B | PRO138 |
| B | GLY141 |
| B | MET149 |
| B | GLY741 |
| B | GLN742 |
| B | HIS780 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | binding site for residue BCO B 1102 |
| Chain | Residue |
| B | PHE585 |
| B | PHE587 |
| B | ARG589 |
| B | ARG856 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | binding site for residue GDP B 1103 |
| Chain | Residue |
| B | GLY219 |
| B | ALA220 |
| B | GLY221 |
| B | LYS222 |
| B | SER223 |
| B | SER224 |
| B | ARG265 |
| B | GLU310 |
| B | GLN341 |
| B | ASN357 |
| B | LYS358 |
| B | ASP360 |
| B | GLN395 |
| B | ALA396 |
| B | SER397 |
| B | GLU973 |
| B | ASN1092 |
| B | MG1104 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 1104 |
| Chain | Residue |
| B | SER223 |
| B | ASP262 |
| B | GLU310 |
| B | GDP1103 |
| B | MG1105 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue MG B 1105 |
| Chain | Residue |
| B | ILE248 |
| B | ASP249 |
| B | ASP262 |
| B | GLU310 |
| B | THR311 |
| B | MG1104 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | Domain: {"description":"B12-binding","evidences":[{"source":"HAMAP-Rule","id":"MF_02050","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25675500","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"HAMAP-Rule","id":"MF_02050","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25675500","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 34 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02050","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25675500","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4XC6","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_02050","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25675500","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 248 |
| Details | Region: {"description":"GTPase chaperone MeaI","evidences":[{"source":"HAMAP-Rule","id":"MF_02050","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25675500","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 161 |
| Details | Region: {"description":"Linker","evidences":[{"source":"HAMAP-Rule","id":"MF_02050","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"25675500","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
