5CI9
Crystal structure of human Tob in complex with inhibitor fragment 6
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003714 | molecular_function | transcription corepressor activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0010468 | biological_process | regulation of gene expression |
| A | 0017148 | biological_process | negative regulation of translation |
| A | 0030014 | cellular_component | CCR4-NOT complex |
| A | 0030971 | molecular_function | receptor tyrosine kinase binding |
| A | 0045892 | biological_process | negative regulation of DNA-templated transcription |
| A | 0046332 | molecular_function | SMAD binding |
| A | 0060212 | biological_process | negative regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| A | 0060213 | biological_process | positive regulation of nuclear-transcribed mRNA poly(A) tail shortening |
| A | 1900153 | biological_process | positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue 549 A 401 |
| Chain | Residue |
| A | PRO49 |
| A | ASP78 |
| A | ASP81 |
| A | PHE97 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue 549 A 402 |
| Chain | Residue |
| A | ARG23 |
| A | HIS59 |
| A | LYS63 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue NA A 403 |
| Chain | Residue |
| A | ARG24 |
| A | SER53 |
| A | TRP93 |
| A | HOH505 |
| A | PRO21 |
| A | ARG23 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 10 |
| Details | Region: {"description":"Important for nuclear localization","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 17 |
| Details | Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
