5CI8

Crystal structure of human Tob in complex with inhibitor fragment 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003714	molecular_function	transcription corepressor activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0008285	biological_process	negative regulation of cell population proliferation
A	0010468	biological_process	regulation of gene expression
A	0017148	biological_process	negative regulation of translation
A	0030014	cellular_component	CCR4-NOT complex
A	0030971	molecular_function	receptor tyrosine kinase binding
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0046332	molecular_function	SMAD binding
A	0060212	biological_process	negative regulation of nuclear-transcribed mRNA poly(A) tail shortening
A	0060213	biological_process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
A	1900153	biological_process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue 53Y A 401

Chain	Residue
A	PRO21
A	ARG23
A	ARG24
A	GLY54
A	TRP93

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Functional Information from PROSITE/UniProt

site_id	PS00960
Number of Residues	21
Details	BTG_1 BTG family signature 1. YegHWYPEkPyKGsGFRCIHI

Chain	Residue	Details
A	TYR40-ILE60

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site_id	PS01203
Number of Residues	20
Details	BTG_2 BTG family signature 2. LPqDLSVWIDPfEVSyQiGE

Chain	Residue	Details
A	LEU86-GLU105

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	Region: {"description":"Important for nuclear localization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	17
Details	Motif: {"description":"Bipartite nuclear localization signal","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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