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5CGJ

Crystal structure of murine Keap1 in complex with RA839, a non-covalent small-molecule binder to Keap1 and selective activator of Nrf2 signalling.

Functional Information from GO Data
ChainGOidnamespacecontents
A0008134molecular_functiontranscription factor binding
A0016567biological_processprotein ubiquitination
A0031463cellular_componentCul3-RING ubiquitin ligase complex
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue SO4 A 701
ChainResidue
AHIS562
AGLN563
AVAL608
AHOH803

site_idAC2
Number of Residues6
Detailsbinding site for residue SO4 A 702
ChainResidue
AARG494
AILE435
AHIS436
AHIS437
ASER438
ASER439

site_idAC3
Number of Residues7
Detailsbinding site for residue SO4 A 703
ChainResidue
ACYS434
AILE435
AHIS436
AARG459
AASP479
AARG494
AARG498

site_idAC4
Number of Residues5
Detailsbinding site for residue SO4 A 704
ChainResidue
AARG380
AASN382
AASN414
AARG415
A51M705

site_idAC5
Number of Residues12
Detailsbinding site for residue 51M A 705
ChainResidue
ATYR334
ASER363
AGLY364
AASN382
AARG415
AARG483
ASER508
ATYR525
AALA556
ASER602
AGLY603
ASO4704

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues45
DetailsRepeat: {"description":"Kelch 1"}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues50
DetailsRepeat: {"description":"Kelch 2"}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues46
DetailsRepeat: {"description":"Kelch 3"}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues46
DetailsRepeat: {"description":"Kelch 4"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues45
DetailsRepeat: {"description":"Kelch 5"}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues46
DetailsRepeat: {"description":"Kelch 6"}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues1
DetailsSite: {"description":"Sensor for electrophilic agents","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues1
DetailsModified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"PubMed","id":"20498371","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues1
DetailsModified residue: {"description":"S-(2-succinyl)cysteine","evidences":[{"source":"PubMed","id":"22014577","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246905

PDB entries from 2025-12-31

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