5CE8

Crystal structure of branched-chain aminotransferase from thermophilic archaea Thermoproteus uzoniensis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004084	molecular_function	branched-chain-amino-acid transaminase activity
A	0008483	molecular_function	transaminase activity
A	0008652	biological_process	amino acid biosynthetic process
A	0009081	biological_process	branched-chain amino acid metabolic process
A	0009082	biological_process	branched-chain amino acid biosynthetic process
A	0009097	biological_process	isoleucine biosynthetic process
A	0009098	biological_process	L-leucine biosynthetic process
A	0009099	biological_process	L-valine biosynthetic process
A	0016740	molecular_function	transferase activity
A	0019752	biological_process	carboxylic acid metabolic process
A	0046394	biological_process	carboxylic acid biosynthetic process
A	0052654	molecular_function	L-leucine-2-oxoglutarate transaminase activity
A	0052655	molecular_function	L-valine-2-oxoglutarate transaminase activity
A	0052656	molecular_function	L-isoleucine-2-oxoglutarate transaminase activity
B	0003824	molecular_function	catalytic activity
B	0004084	molecular_function	branched-chain-amino-acid transaminase activity
B	0008483	molecular_function	transaminase activity
B	0008652	biological_process	amino acid biosynthetic process
B	0009081	biological_process	branched-chain amino acid metabolic process
B	0009082	biological_process	branched-chain amino acid biosynthetic process
B	0009097	biological_process	isoleucine biosynthetic process
B	0009098	biological_process	L-leucine biosynthetic process
B	0009099	biological_process	L-valine biosynthetic process
B	0016740	molecular_function	transferase activity
B	0019752	biological_process	carboxylic acid metabolic process
B	0046394	biological_process	carboxylic acid biosynthetic process
B	0052654	molecular_function	L-leucine-2-oxoglutarate transaminase activity
B	0052655	molecular_function	L-valine-2-oxoglutarate transaminase activity
B	0052656	molecular_function	L-isoleucine-2-oxoglutarate transaminase activity
C	0003824	molecular_function	catalytic activity
C	0004084	molecular_function	branched-chain-amino-acid transaminase activity
C	0008483	molecular_function	transaminase activity
C	0008652	biological_process	amino acid biosynthetic process
C	0009081	biological_process	branched-chain amino acid metabolic process
C	0009082	biological_process	branched-chain amino acid biosynthetic process
C	0009097	biological_process	isoleucine biosynthetic process
C	0009098	biological_process	L-leucine biosynthetic process
C	0009099	biological_process	L-valine biosynthetic process
C	0016740	molecular_function	transferase activity
C	0019752	biological_process	carboxylic acid metabolic process
C	0046394	biological_process	carboxylic acid biosynthetic process
C	0052654	molecular_function	L-leucine-2-oxoglutarate transaminase activity
C	0052655	molecular_function	L-valine-2-oxoglutarate transaminase activity
C	0052656	molecular_function	L-isoleucine-2-oxoglutarate transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	binding site for residue PLP A 301

Chain	Residue
A	HIS51
A	THR212
A	THR248
A	HOH422
A	HOH462
A	ARG54
A	LYS150
A	TYR155
A	GLU184
A	GLU188
A	LEU208
A	GLY210
A	ILE211

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site_id	AC2
Number of Residues	4
Details	binding site for residue PEG C 301

Chain	Residue
C	PRO101
C	GLN102
C	ILE103
C	SER104

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site_id	AC3
Number of Residues	19
Details	binding site for Di-peptide PLP B 301 and LYS B 150

Chain	Residue
B	VAL30
B	PHE31
B	HIS51
B	ARG54
B	SER58
B	ALA149
B	ALA151
B	TYR155
B	GLU184
B	GLY187
B	GLU188
B	ASN189
B	GLY210
B	ILE211
B	THR212
B	GLY247
B	THR248
B	HOH428
B	HOH445

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site_id	AC4
Number of Residues	20
Details	binding site for Di-peptide PLP C 302 and LYS C 150

Chain	Residue
C	VAL30
C	PHE31
C	HIS51
C	ARG54
C	SER58
C	ALA149
C	ALA151
C	TYR155
C	GLU184
C	GLY187
C	GLU188
C	ASN189
C	LEU208
C	GLY210
C	ILE211
C	THR212
C	GLY247
C	THR248
C	HOH416
C	HOH449

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Functional Information from PROSITE/UniProt

site_id	PS00445
Number of Residues	21
Details	FGGY_KINASES_2 FGGY family of carbohydrate kinases signature 2. AkIIGLdvpytae.ELSKAVVE

Chain	Residue	Details
A	ALA59-GLU79

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site_id	PS00770
Number of Residues	30
Details	AA_TRANSFER_CLASS_4 Aminotransferases class-IV signature. EgSgeNIFivrrgv......LmTppledgi.LeGItR

Chain	Residue	Details
A	GLU184-ARG213

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