5CE5

Probing the roles of two tryptophans surrounding the unique zinc coordination site in lipase family I.5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004806	molecular_function	triacylglycerol lipase activity
A	0005576	cellular_component	extracellular region
A	0006629	biological_process	lipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue CA A 401

Chain	Residue
A	GLY287
A	GLU361
A	ASP366
A	PRO367
A	HOH790

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site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 402

Chain	Residue
A	ASP62
A	HIS82
A	HIS88
A	ASP239

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site_id	AC3
Number of Residues	9
Details	binding site for residue P15 A 403

Chain	Residue
A	PHE17
A	LEU57
A	SER114
A	GLN115
A	LEU184
A	LEU189
A	THR240
A	ILE320
A	HIS359

---

site_id	AC4
Number of Residues	6
Details	binding site for residue 1PE A 404

Chain	Residue
A	THR18
A	MET174
A	THR178
A	PHE222
A	LEU360
A	HOH556

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site_id	AC5
Number of Residues	6
Details	binding site for residue MPD A 405

Chain	Residue
A	THR18
A	LEU57
A	VAL188
A	TYR205
A	PHE207
A	HOH504

---

site_id	AC6
Number of Residues	4
Details	binding site for residue MPD A 406

Chain	Residue
A	ASN142
A	VAL143
A	HOH573
A	HOH644

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site_id	AC7
Number of Residues	2
Details	binding site for residue MPD A 407

Chain	Residue
A	ASN197
A	ARG216

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