5C8U

Crystal structure of the SARS coronavirus nsp14-nsp10 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0008270	molecular_function	zinc ion binding
A	0019079	biological_process	viral genome replication
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
B	0004532	molecular_function	RNA exonuclease activity
B	0008168	molecular_function	methyltransferase activity
C	0003723	molecular_function	RNA binding
C	0008270	molecular_function	zinc ion binding
C	0019079	biological_process	viral genome replication
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0004482	molecular_function	mRNA 5'-cap (guanine-N7-)-methyltransferase activity
D	0004532	molecular_function	RNA exonuclease activity
D	0008168	molecular_function	methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 201

Chain	Residue
A	CYS74
A	CYS77
A	HIS83
A	CYS90

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 202

Chain	Residue
A	CYS117
A	CYS120
A	CYS128
A	CYS130

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ZN B 601

Chain	Residue
B	CYS210
B	CYS226
B	HIS229
B	CYS207

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN B 602

Chain	Residue
B	HIS257
B	CYS261
B	HIS264
B	CYS279

---

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN B 603

Chain	Residue
B	CYS452
B	CYS477
B	CYS484
B	HIS487

---

site_id	AC6
Number of Residues	3
Details	binding site for residue MG B 604

Chain	Residue
B	ASP90
B	ALA187
B	GLU191

---

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN C 201

Chain	Residue
C	CYS74
C	CYS77
C	HIS83
C	CYS90

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN C 202

Chain	Residue
C	CYS117
C	CYS120
C	CYS128
C	CYS130

---

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN D 601

Chain	Residue
D	CYS207
D	CYS210
D	CYS226
D	HIS229

---

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN D 602

Chain	Residue
D	HIS257
D	CYS261
D	HIS264
D	CYS279

---

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN D 603

Chain	Residue
D	CYS452
D	CYS477
D	CYS484
D	HIS487

---

site_id	AD3
Number of Residues	3
Details	binding site for residue MG D 604

Chain	Residue
D	ASP90
D	ALA187
D	GLU191

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU01298

Chain	Residue	Details
B	ASP90
D	ASP273
B	GLU92
B	GLU191
B	HIS268
B	ASP273
D	ASP90
D	GLU92
D	GLU191
D	HIS268

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P0DTD1

Chain	Residue	Details
B	GLU92
C	CYS77
C	HIS83
C	CYS90
C	CYS117
C	CYS120
C	CYS128
C	CYS130
B	GLU191
B	HIS268
B	ASP273
D	GLU92
D	GLU191
D	HIS268
D	ASP273
C	CYS74

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01298

Chain	Residue	Details
B	CYS207
D	CYS210
D	CYS226
D	HIS229
D	HIS257
D	CYS261
D	HIS264
D	CYS279
B	CYS210
B	CYS226
B	HIS229
B	HIS257
B	CYS261
B	HIS264
B	CYS279
D	CYS207

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01299

Chain	Residue	Details
B	ASP331
D	HIS487
B	CYS452
B	CYS473
B	CYS484
B	HIS487
D	ASP331
D	CYS452
D	CYS473
D	CYS484

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	SITE: Cleavage; by 3CL-PRO => ECO:0000269|PubMed:14561748

Chain	Residue	Details
B	GLN527
D	GLN527

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

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site_id	MCSA2
Number of Residues
Details	M-CSA 830

Chain

Residue

Details

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