5C84

Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Compound 20

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue ZN A 401

Chain	Residue
A	CYS300
A	CYS303
A	HIS320
A	CYS327

---

site_id	AC2
Number of Residues	11
Details	binding site for residue 4YL A 402

Chain	Residue
A	TRP310
A	GLU314
A	GLN319
A	TRP323
A	TYR324
A	HOH577
A	LYS297
A	GLY306
A	LEU307
A	THR308
A	ASP309

---

Functional Information from PROSITE/UniProt

site_id	PS01282
Number of Residues	66
Details	BIR_REPEAT_1 BIR repeat. YeaRiftfgt.Wiysvnkeqlar...AGFyAlgegDkvkCfhCgggltdWkpsedpweqHakwyPgCkyL

Chain	Residue	Details
A	TYR265-LEU330

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	65
Details	Repeat: {"description":"BIR 3"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	15
Details	Region: {"description":"Required for interaction with SEPTIN4 isoform ARTS","evidences":[{"source":"PubMed","id":"21695558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Region: {"description":"Required for interaction with DIABLO","evidences":[{"source":"PubMed","id":"21695558","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00029","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	3
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"12747801","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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