5C80
X-ray structure uridine phosphorylase from Vibrio cholerae in complex with uridine at 2.24 A resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004850 | molecular_function | uridine phosphorylase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0009116 | biological_process | nucleoside metabolic process |
| A | 0009164 | biological_process | nucleoside catabolic process |
| A | 0009166 | biological_process | nucleotide catabolic process |
| A | 0016757 | molecular_function | glycosyltransferase activity |
| A | 0016763 | molecular_function | pentosyltransferase activity |
| A | 0044206 | biological_process | UMP salvage |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004850 | molecular_function | uridine phosphorylase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0009116 | biological_process | nucleoside metabolic process |
| B | 0009164 | biological_process | nucleoside catabolic process |
| B | 0009166 | biological_process | nucleotide catabolic process |
| B | 0016757 | molecular_function | glycosyltransferase activity |
| B | 0016763 | molecular_function | pentosyltransferase activity |
| B | 0044206 | biological_process | UMP salvage |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004850 | molecular_function | uridine phosphorylase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0009116 | biological_process | nucleoside metabolic process |
| C | 0009164 | biological_process | nucleoside catabolic process |
| C | 0009166 | biological_process | nucleotide catabolic process |
| C | 0016757 | molecular_function | glycosyltransferase activity |
| C | 0016763 | molecular_function | pentosyltransferase activity |
| C | 0044206 | biological_process | UMP salvage |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004850 | molecular_function | uridine phosphorylase activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0005829 | cellular_component | cytosol |
| D | 0009116 | biological_process | nucleoside metabolic process |
| D | 0009164 | biological_process | nucleoside catabolic process |
| D | 0009166 | biological_process | nucleotide catabolic process |
| D | 0016757 | molecular_function | glycosyltransferase activity |
| D | 0016763 | molecular_function | pentosyltransferase activity |
| D | 0044206 | biological_process | UMP salvage |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| E | 0003824 | molecular_function | catalytic activity |
| E | 0004850 | molecular_function | uridine phosphorylase activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0005829 | cellular_component | cytosol |
| E | 0009116 | biological_process | nucleoside metabolic process |
| E | 0009164 | biological_process | nucleoside catabolic process |
| E | 0009166 | biological_process | nucleotide catabolic process |
| E | 0016757 | molecular_function | glycosyltransferase activity |
| E | 0016763 | molecular_function | pentosyltransferase activity |
| E | 0044206 | biological_process | UMP salvage |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
| F | 0003824 | molecular_function | catalytic activity |
| F | 0004850 | molecular_function | uridine phosphorylase activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0005829 | cellular_component | cytosol |
| F | 0009116 | biological_process | nucleoside metabolic process |
| F | 0009164 | biological_process | nucleoside catabolic process |
| F | 0009166 | biological_process | nucleotide catabolic process |
| F | 0016757 | molecular_function | glycosyltransferase activity |
| F | 0016763 | molecular_function | pentosyltransferase activity |
| F | 0044206 | biological_process | UMP salvage |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0047847 | molecular_function | deoxyuridine phosphorylase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 15 |
| Details | binding site for residue URI A 301 |
| Chain | Residue |
| A | ILE68 |
| A | GLU197 |
| A | ILE220 |
| A | HOH434 |
| A | HOH450 |
| A | HOH467 |
| B | HIS7 |
| A | ARG90 |
| A | THR93 |
| A | THR94 |
| A | GLY95 |
| A | GLN165 |
| A | ARG167 |
| A | GLU195 |
| A | MET196 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue TRS A 302 |
| Chain | Residue |
| A | ASP132 |
| A | CYS205 |
| A | ALA206 |
| A | GLY209 |
| A | LEU210 |
| A | HOH401 |
| A | HOH406 |
| A | HOH410 |
| A | HOH422 |
| A | HOH425 |
| A | HOH428 |
| A | HOH436 |
| A | HOH474 |
| F | MET152 |
| F | GLY153 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue PEG A 303 |
| Chain | Residue |
| A | SER208 |
| A | GLY209 |
| A | HOH461 |
| F | GLN187 |
| F | ASP188 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue CL A 304 |
| Chain | Residue |
| A | GLY25 |
| A | ASP26 |
| A | ARG29 |
| B | ARG47 |
| site_id | AC5 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 305 |
| Chain | Residue |
| A | TYR168 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | binding site for residue URI B 301 |
| Chain | Residue |
| A | HIS7 |
| B | ILE68 |
| B | ARG90 |
| B | THR93 |
| B | THR94 |
| B | GLY95 |
| B | GLN165 |
| B | ARG167 |
| B | GLU195 |
| B | MET196 |
| B | GLU197 |
| B | ILE220 |
| B | HOH409 |
| B | HOH411 |
| B | HOH480 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | binding site for residue TRS B 302 |
| Chain | Residue |
| B | ASP132 |
| B | CYS205 |
| B | ALA206 |
| B | LEU210 |
| B | HOH401 |
| B | HOH402 |
| B | HOH403 |
| B | HOH451 |
| B | HOH486 |
| C | HOH411 |
| C | HOH436 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 303 |
| Chain | Residue |
| A | GLN82 |
| B | THR170 |
| B | PHE171 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | binding site for residue PEG B 304 |
| Chain | Residue |
| B | ASP188 |
| B | HOH513 |
| C | SER208 |
| C | GLY209 |
| C | HOH502 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue CL B 305 |
| Chain | Residue |
| A | ARG47 |
| B | GLY25 |
| B | ASP26 |
| site_id | AD2 |
| Number of Residues | 6 |
| Details | binding site for residue NA B 306 |
| Chain | Residue |
| A | GLU48 |
| A | ILE68 |
| A | SER72 |
| B | GLU48 |
| B | ILE68 |
| B | SER72 |
| site_id | AD3 |
| Number of Residues | 12 |
| Details | binding site for residue URI C 301 |
| Chain | Residue |
| C | THR93 |
| C | THR94 |
| C | GLY95 |
| C | PHE161 |
| C | GLN165 |
| C | ARG167 |
| C | MET196 |
| C | GLU197 |
| C | HOH401 |
| C | HOH418 |
| C | HOH430 |
| D | HIS7 |
| site_id | AD4 |
| Number of Residues | 12 |
| Details | binding site for residue TRS C 302 |
| Chain | Residue |
| C | LEU210 |
| C | LYS211 |
| C | HOH402 |
| C | HOH413 |
| C | HOH417 |
| C | HOH425 |
| C | HOH463 |
| C | HOH478 |
| C | ASP132 |
| C | CYS205 |
| C | ALA206 |
| C | GLY209 |
| site_id | AD5 |
| Number of Residues | 4 |
| Details | binding site for residue PEG C 303 |
| Chain | Residue |
| B | SER208 |
| B | GLY209 |
| C | GLN187 |
| C | ASP188 |
| site_id | AD6 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 304 |
| Chain | Residue |
| C | GLY25 |
| C | ASP26 |
| C | ARG29 |
| site_id | AD7 |
| Number of Residues | 14 |
| Details | binding site for residue URI D 301 |
| Chain | Residue |
| C | HIS7 |
| D | ILE68 |
| D | THR93 |
| D | THR94 |
| D | GLY95 |
| D | PHE161 |
| D | GLN165 |
| D | ARG167 |
| D | GLU195 |
| D | MET196 |
| D | GLU197 |
| D | ILE220 |
| D | HOH408 |
| D | HOH472 |
| site_id | AD8 |
| Number of Residues | 12 |
| Details | binding site for residue TRS D 302 |
| Chain | Residue |
| D | ASP132 |
| D | CYS205 |
| D | ALA206 |
| D | GLY209 |
| D | LEU210 |
| D | HOH401 |
| D | HOH404 |
| D | HOH405 |
| D | HOH411 |
| D | HOH414 |
| D | HOH447 |
| E | HOH448 |
| site_id | AD9 |
| Number of Residues | 10 |
| Details | binding site for residue TRS D 303 |
| Chain | Residue |
| B | GLN31 |
| B | GLU35 |
| B | PRO40 |
| B | HOH417 |
| D | ASP38 |
| D | ASN39 |
| D | PRO40 |
| D | HOH432 |
| F | TRS302 |
| F | TRS304 |
| site_id | AE1 |
| Number of Residues | 6 |
| Details | binding site for residue GOL D 304 |
| Chain | Residue |
| D | GLN31 |
| D | GLU35 |
| D | PRO40 |
| D | PHE42 |
| F | ASN39 |
| F | TRS304 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue CL D 305 |
| Chain | Residue |
| D | GLY25 |
| D | ASP26 |
| site_id | AE3 |
| Number of Residues | 16 |
| Details | binding site for residue URI E 301 |
| Chain | Residue |
| E | ILE68 |
| E | THR93 |
| E | THR94 |
| E | GLY95 |
| E | PHE161 |
| E | GLN165 |
| E | ARG167 |
| E | PHE194 |
| E | GLU195 |
| E | MET196 |
| E | GLU197 |
| E | ILE220 |
| E | HOH419 |
| E | HOH421 |
| E | HOH423 |
| F | HIS7 |
| site_id | AE4 |
| Number of Residues | 14 |
| Details | binding site for residue TRS E 302 |
| Chain | Residue |
| D | MET152 |
| D | GLY153 |
| D | HOH463 |
| E | ASP132 |
| E | CYS205 |
| E | ALA206 |
| E | GLY209 |
| E | LEU210 |
| E | HOH401 |
| E | HOH404 |
| E | HOH407 |
| E | HOH413 |
| E | HOH428 |
| E | HOH471 |
| site_id | AE5 |
| Number of Residues | 15 |
| Details | binding site for residue URI F 301 |
| Chain | Residue |
| E | HIS7 |
| F | ILE68 |
| F | ARG90 |
| F | THR93 |
| F | THR94 |
| F | GLY95 |
| F | GLN165 |
| F | ARG167 |
| F | PHE194 |
| F | GLU195 |
| F | MET196 |
| F | GLU197 |
| F | HOH436 |
| F | HOH467 |
| F | HOH488 |
| site_id | AE6 |
| Number of Residues | 10 |
| Details | binding site for residue TRS F 302 |
| Chain | Residue |
| B | ASP38 |
| B | ASN39 |
| B | PRO40 |
| B | HOH421 |
| D | TRS303 |
| F | GLN31 |
| F | GLU35 |
| F | PRO40 |
| F | TRS304 |
| F | HOH413 |
| site_id | AE7 |
| Number of Residues | 13 |
| Details | binding site for residue TRS F 303 |
| Chain | Residue |
| A | HOH408 |
| F | ASP132 |
| F | CYS205 |
| F | ALA206 |
| F | GLY209 |
| F | LEU210 |
| F | HOH401 |
| F | HOH404 |
| F | HOH408 |
| F | HOH430 |
| F | HOH432 |
| F | HOH444 |
| F | HOH453 |
| site_id | AE8 |
| Number of Residues | 7 |
| Details | binding site for residue TRS F 304 |
| Chain | Residue |
| B | GLU35 |
| D | GLU35 |
| D | TRS303 |
| D | GOL304 |
| F | GLU35 |
| F | TRS302 |
| F | HOH463 |
| site_id | AE9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL F 305 |
| Chain | Residue |
| B | ARG174 |
| C | ASN102 |
| F | LYS184 |
| F | ASP188 |
| site_id | AF1 |
| Number of Residues | 3 |
| Details | binding site for residue CL F 306 |
| Chain | Residue |
| F | GLY25 |
| F | ASP26 |
| F | ARG29 |
| site_id | AF2 |
| Number of Residues | 6 |
| Details | binding site for residue NA F 307 |
| Chain | Residue |
| E | GLU48 |
| E | ILE68 |
| E | SER72 |
| F | GLU48 |
| F | ILE68 |
| F | SER72 |
Functional Information from PROSITE/UniProt
| site_id | PS01232 |
| Number of Residues | 16 |
| Details | PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL |
| Chain | Residue | Details |
| A | SER65-LEU80 |
