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5C5X

CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5

Functional Information from GO Data
ChainGOidnamespacecontents
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005886cellular_componentplasma membrane
A0005902cellular_componentmicrovillus
A0006833biological_processwater transport
A0009925cellular_componentbasal plasma membrane
A0015250molecular_functionwater channel activity
A0015267molecular_functionchannel activity
A0015670biological_processcarbon dioxide transport
A0016020cellular_componentmembrane
A0016324cellular_componentapical plasma membrane
A0030157biological_processpancreatic juice secretion
A0030659cellular_componentcytoplasmic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0042476biological_processodontogenesis
A0042802molecular_functionidentical protein binding
A0046541biological_processsaliva secretion
A0048593biological_processcamera-type eye morphogenesis
A0051289biological_processprotein homotetramerization
A0055085biological_processtransmembrane transport
A0070062cellular_componentextracellular exosome
A0071476biological_processcellular hypotonic response
B0005515molecular_functionprotein binding
B0005783cellular_componentendoplasmic reticulum
B0005886cellular_componentplasma membrane
B0005902cellular_componentmicrovillus
B0006833biological_processwater transport
B0009925cellular_componentbasal plasma membrane
B0015250molecular_functionwater channel activity
B0015267molecular_functionchannel activity
B0015670biological_processcarbon dioxide transport
B0016020cellular_componentmembrane
B0016324cellular_componentapical plasma membrane
B0030157biological_processpancreatic juice secretion
B0030659cellular_componentcytoplasmic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0042476biological_processodontogenesis
B0042802molecular_functionidentical protein binding
B0046541biological_processsaliva secretion
B0048593biological_processcamera-type eye morphogenesis
B0051289biological_processprotein homotetramerization
B0055085biological_processtransmembrane transport
B0070062cellular_componentextracellular exosome
B0071476biological_processcellular hypotonic response
C0005515molecular_functionprotein binding
C0005783cellular_componentendoplasmic reticulum
C0005886cellular_componentplasma membrane
C0005902cellular_componentmicrovillus
C0006833biological_processwater transport
C0009925cellular_componentbasal plasma membrane
C0015250molecular_functionwater channel activity
C0015267molecular_functionchannel activity
C0015670biological_processcarbon dioxide transport
C0016020cellular_componentmembrane
C0016324cellular_componentapical plasma membrane
C0030157biological_processpancreatic juice secretion
C0030659cellular_componentcytoplasmic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0042476biological_processodontogenesis
C0042802molecular_functionidentical protein binding
C0046541biological_processsaliva secretion
C0048593biological_processcamera-type eye morphogenesis
C0051289biological_processprotein homotetramerization
C0055085biological_processtransmembrane transport
C0070062cellular_componentextracellular exosome
C0071476biological_processcellular hypotonic response
D0005515molecular_functionprotein binding
D0005783cellular_componentendoplasmic reticulum
D0005886cellular_componentplasma membrane
D0005902cellular_componentmicrovillus
D0006833biological_processwater transport
D0009925cellular_componentbasal plasma membrane
D0015250molecular_functionwater channel activity
D0015267molecular_functionchannel activity
D0015670biological_processcarbon dioxide transport
D0016020cellular_componentmembrane
D0016324cellular_componentapical plasma membrane
D0030157biological_processpancreatic juice secretion
D0030659cellular_componentcytoplasmic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0042476biological_processodontogenesis
D0042802molecular_functionidentical protein binding
D0046541biological_processsaliva secretion
D0048593biological_processcamera-type eye morphogenesis
D0051289biological_processprotein homotetramerization
D0055085biological_processtransmembrane transport
D0070062cellular_componentextracellular exosome
D0071476biological_processcellular hypotonic response
E0005515molecular_functionprotein binding
E0005783cellular_componentendoplasmic reticulum
E0005886cellular_componentplasma membrane
E0005902cellular_componentmicrovillus
E0006833biological_processwater transport
E0009925cellular_componentbasal plasma membrane
E0015250molecular_functionwater channel activity
E0015267molecular_functionchannel activity
E0015670biological_processcarbon dioxide transport
E0016020cellular_componentmembrane
E0016324cellular_componentapical plasma membrane
E0030157biological_processpancreatic juice secretion
E0030659cellular_componentcytoplasmic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0042476biological_processodontogenesis
E0042802molecular_functionidentical protein binding
E0046541biological_processsaliva secretion
E0048593biological_processcamera-type eye morphogenesis
E0051289biological_processprotein homotetramerization
E0055085biological_processtransmembrane transport
E0070062cellular_componentextracellular exosome
E0071476biological_processcellular hypotonic response
F0005515molecular_functionprotein binding
F0005783cellular_componentendoplasmic reticulum
F0005886cellular_componentplasma membrane
F0005902cellular_componentmicrovillus
F0006833biological_processwater transport
F0009925cellular_componentbasal plasma membrane
F0015250molecular_functionwater channel activity
F0015267molecular_functionchannel activity
F0015670biological_processcarbon dioxide transport
F0016020cellular_componentmembrane
F0016324cellular_componentapical plasma membrane
F0030157biological_processpancreatic juice secretion
F0030659cellular_componentcytoplasmic vesicle membrane
F0031410cellular_componentcytoplasmic vesicle
F0042476biological_processodontogenesis
F0042802molecular_functionidentical protein binding
F0046541biological_processsaliva secretion
F0048593biological_processcamera-type eye morphogenesis
F0051289biological_processprotein homotetramerization
F0055085biological_processtransmembrane transport
F0070062cellular_componentextracellular exosome
F0071476biological_processcellular hypotonic response
G0005515molecular_functionprotein binding
G0005783cellular_componentendoplasmic reticulum
G0005886cellular_componentplasma membrane
G0005902cellular_componentmicrovillus
G0006833biological_processwater transport
G0009925cellular_componentbasal plasma membrane
G0015250molecular_functionwater channel activity
G0015267molecular_functionchannel activity
G0015670biological_processcarbon dioxide transport
G0016020cellular_componentmembrane
G0016324cellular_componentapical plasma membrane
G0030157biological_processpancreatic juice secretion
G0030659cellular_componentcytoplasmic vesicle membrane
G0031410cellular_componentcytoplasmic vesicle
G0042476biological_processodontogenesis
G0042802molecular_functionidentical protein binding
G0046541biological_processsaliva secretion
G0048593biological_processcamera-type eye morphogenesis
G0051289biological_processprotein homotetramerization
G0055085biological_processtransmembrane transport
G0070062cellular_componentextracellular exosome
G0071476biological_processcellular hypotonic response
H0005515molecular_functionprotein binding
H0005783cellular_componentendoplasmic reticulum
H0005886cellular_componentplasma membrane
H0005902cellular_componentmicrovillus
H0006833biological_processwater transport
H0009925cellular_componentbasal plasma membrane
H0015250molecular_functionwater channel activity
H0015267molecular_functionchannel activity
H0015670biological_processcarbon dioxide transport
H0016020cellular_componentmembrane
H0016324cellular_componentapical plasma membrane
H0030157biological_processpancreatic juice secretion
H0030659cellular_componentcytoplasmic vesicle membrane
H0031410cellular_componentcytoplasmic vesicle
H0042476biological_processodontogenesis
H0042802molecular_functionidentical protein binding
H0046541biological_processsaliva secretion
H0048593biological_processcamera-type eye morphogenesis
H0051289biological_processprotein homotetramerization
H0055085biological_processtransmembrane transport
H0070062cellular_componentextracellular exosome
H0071476biological_processcellular hypotonic response
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue PS6 D 301
ChainResidue
AVAL158
DPRO157
DVAL158
DGLY159
DLEU163
DHOH411
DHOH432
DHOH438
AGLY159
ASER160
BGLY159
BSER160
CGLY159
CSER160
CLEU163
CHOH305

site_idAC2
Number of Residues14
Detailsbinding site for residue PS6 H 301
ChainResidue
EGLY159
ESER160
FGLY159
GGLY159
GSER160
GLEU163
HPRO157
HVAL158
HGLY159
HSER160
HHOH419
HHOH423
HHOH429
HHOH464

Functional Information from PROSITE/UniProt
site_idPS00221
Number of Residues9
DetailsMIP MIP family signature. HINPAITLA
ChainResidueDetails
AHIS67-ALA75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues296
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
AMET1-LYS12
CGLY61-GLY65
CALA75-ALA87
CALA148-VAL158
DMET1-LYS12
DGLY61-GLY65
DALA75-ALA87
DALA148-VAL158
EMET1-LYS12
EGLY61-GLY65
EALA75-ALA87
AGLY61-GLY65
EALA148-VAL158
FMET1-LYS12
FGLY61-GLY65
FALA75-ALA87
FALA148-VAL158
GMET1-LYS12
GGLY61-GLY65
GALA75-ALA87
GALA148-VAL158
HMET1-LYS12
AALA75-ALA87
HGLY61-GLY65
HALA75-ALA87
HALA148-VAL158
AALA148-VAL158
BMET1-LYS12
BGLY61-GLY65
BALA75-ALA87
BALA148-VAL158
CMET1-LYS12

site_idSWS_FT_FI2
Number of Residues960
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
AALA13-LEU33
BTHR127-PHE147
BGLY159-PHE179
BTRP204-LEU224
CALA13-LEU33
CPRO40-LEU60
CPHE88-VAL108
CTHR127-PHE147
CGLY159-PHE179
CTRP204-LEU224
DALA13-LEU33
APRO40-LEU60
DPRO40-LEU60
DPHE88-VAL108
DTHR127-PHE147
DGLY159-PHE179
DTRP204-LEU224
EALA13-LEU33
EPRO40-LEU60
EPHE88-VAL108
ETHR127-PHE147
EGLY159-PHE179
APHE88-VAL108
ETRP204-LEU224
FALA13-LEU33
FPRO40-LEU60
FPHE88-VAL108
FTHR127-PHE147
FGLY159-PHE179
FTRP204-LEU224
GALA13-LEU33
GPRO40-LEU60
GPHE88-VAL108
ATHR127-PHE147
GTHR127-PHE147
GGLY159-PHE179
GTRP204-LEU224
HALA13-LEU33
HPRO40-LEU60
HPHE88-VAL108
HTHR127-PHE147
HGLY159-PHE179
HTRP204-LEU224
AGLY159-PHE179
ATRP204-LEU224
BALA13-LEU33
BPRO40-LEU60
BPHE88-VAL108

site_idSWS_FT_FI3
Number of Residues272
DetailsTOPO_DOM: Extracellular => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
ALYS34-LEU39
CALA109-THR126
CTHR180
CPRO192-HIS203
DLYS34-LEU39
DALA109-THR126
DTHR180
DPRO192-HIS203
ELYS34-LEU39
EALA109-THR126
ETHR180
AALA109-THR126
EPRO192-HIS203
FLYS34-LEU39
FALA109-THR126
FTHR180
FPRO192-HIS203
GLYS34-LEU39
GALA109-THR126
GTHR180
GPRO192-HIS203
HLYS34-LEU39
ATHR180
HALA109-THR126
HTHR180
HPRO192-HIS203
APRO192-HIS203
BLYS34-LEU39
BALA109-THR126
BTHR180
BPRO192-HIS203
CLYS34-LEU39

site_idSWS_FT_FI4
Number of Residues144
DetailsINTRAMEM: Discontinuously helical => ECO:0000269|PubMed:18768791, ECO:0000269|PubMed:26569106
ChainResidueDetails
AGLY66-LEU74
EGLY181-GLY191
FGLY66-LEU74
FGLY181-GLY191
GGLY66-LEU74
GGLY181-GLY191
HGLY66-LEU74
HGLY181-GLY191
AGLY181-GLY191
BGLY66-LEU74
BGLY181-GLY191
CGLY66-LEU74
CGLY181-GLY191
DGLY66-LEU74
DGLY181-GLY191
EGLY66-LEU74

site_idSWS_FT_FI5
Number of Residues16
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN124
EASN125
FASN124
FASN125
GASN124
GASN125
HASN124
HASN125
AASN125
BASN124
BASN125
CASN124
CASN125
DASN124
DASN125
EASN124

224201

PDB entries from 2024-08-28

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