Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5C5X

CRYSTAL STRUCTURE OF THE S156E MUTANT OF HUMAN AQUAPORIN 5

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005783	cellular_component	endoplasmic reticulum
A	0005886	cellular_component	plasma membrane
A	0005902	cellular_component	microvillus
A	0006833	biological_process	water transport
A	0009925	cellular_component	basal plasma membrane
A	0015250	molecular_function	water channel activity
A	0015267	molecular_function	channel activity
A	0015670	biological_process	carbon dioxide transport
A	0016020	cellular_component	membrane
A	0016324	cellular_component	apical plasma membrane
A	0030157	biological_process	pancreatic juice secretion
A	0030659	cellular_component	cytoplasmic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0042476	biological_process	odontogenesis
A	0042802	molecular_function	identical protein binding
A	0051289	biological_process	protein homotetramerization
A	0055085	biological_process	transmembrane transport
A	0070062	cellular_component	extracellular exosome
A	0071476	biological_process	cellular hypotonic response
B	0005515	molecular_function	protein binding
B	0005783	cellular_component	endoplasmic reticulum
B	0005886	cellular_component	plasma membrane
B	0005902	cellular_component	microvillus
B	0006833	biological_process	water transport
B	0009925	cellular_component	basal plasma membrane
B	0015250	molecular_function	water channel activity
B	0015267	molecular_function	channel activity
B	0015670	biological_process	carbon dioxide transport
B	0016020	cellular_component	membrane
B	0016324	cellular_component	apical plasma membrane
B	0030157	biological_process	pancreatic juice secretion
B	0030659	cellular_component	cytoplasmic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0042476	biological_process	odontogenesis
B	0042802	molecular_function	identical protein binding
B	0051289	biological_process	protein homotetramerization
B	0055085	biological_process	transmembrane transport
B	0070062	cellular_component	extracellular exosome
B	0071476	biological_process	cellular hypotonic response
C	0005515	molecular_function	protein binding
C	0005783	cellular_component	endoplasmic reticulum
C	0005886	cellular_component	plasma membrane
C	0005902	cellular_component	microvillus
C	0006833	biological_process	water transport
C	0009925	cellular_component	basal plasma membrane
C	0015250	molecular_function	water channel activity
C	0015267	molecular_function	channel activity
C	0015670	biological_process	carbon dioxide transport
C	0016020	cellular_component	membrane
C	0016324	cellular_component	apical plasma membrane
C	0030157	biological_process	pancreatic juice secretion
C	0030659	cellular_component	cytoplasmic vesicle membrane
C	0031410	cellular_component	cytoplasmic vesicle
C	0042476	biological_process	odontogenesis
C	0042802	molecular_function	identical protein binding
C	0051289	biological_process	protein homotetramerization
C	0055085	biological_process	transmembrane transport
C	0070062	cellular_component	extracellular exosome
C	0071476	biological_process	cellular hypotonic response
D	0005515	molecular_function	protein binding
D	0005783	cellular_component	endoplasmic reticulum
D	0005886	cellular_component	plasma membrane
D	0005902	cellular_component	microvillus
D	0006833	biological_process	water transport
D	0009925	cellular_component	basal plasma membrane
D	0015250	molecular_function	water channel activity
D	0015267	molecular_function	channel activity
D	0015670	biological_process	carbon dioxide transport
D	0016020	cellular_component	membrane
D	0016324	cellular_component	apical plasma membrane
D	0030157	biological_process	pancreatic juice secretion
D	0030659	cellular_component	cytoplasmic vesicle membrane
D	0031410	cellular_component	cytoplasmic vesicle
D	0042476	biological_process	odontogenesis
D	0042802	molecular_function	identical protein binding
D	0051289	biological_process	protein homotetramerization
D	0055085	biological_process	transmembrane transport
D	0070062	cellular_component	extracellular exosome
D	0071476	biological_process	cellular hypotonic response
E	0005515	molecular_function	protein binding
E	0005783	cellular_component	endoplasmic reticulum
E	0005886	cellular_component	plasma membrane
E	0005902	cellular_component	microvillus
E	0006833	biological_process	water transport
E	0009925	cellular_component	basal plasma membrane
E	0015250	molecular_function	water channel activity
E	0015267	molecular_function	channel activity
E	0015670	biological_process	carbon dioxide transport
E	0016020	cellular_component	membrane
E	0016324	cellular_component	apical plasma membrane
E	0030157	biological_process	pancreatic juice secretion
E	0030659	cellular_component	cytoplasmic vesicle membrane
E	0031410	cellular_component	cytoplasmic vesicle
E	0042476	biological_process	odontogenesis
E	0042802	molecular_function	identical protein binding
E	0051289	biological_process	protein homotetramerization
E	0055085	biological_process	transmembrane transport
E	0070062	cellular_component	extracellular exosome
E	0071476	biological_process	cellular hypotonic response
F	0005515	molecular_function	protein binding
F	0005783	cellular_component	endoplasmic reticulum
F	0005886	cellular_component	plasma membrane
F	0005902	cellular_component	microvillus
F	0006833	biological_process	water transport
F	0009925	cellular_component	basal plasma membrane
F	0015250	molecular_function	water channel activity
F	0015267	molecular_function	channel activity
F	0015670	biological_process	carbon dioxide transport
F	0016020	cellular_component	membrane
F	0016324	cellular_component	apical plasma membrane
F	0030157	biological_process	pancreatic juice secretion
F	0030659	cellular_component	cytoplasmic vesicle membrane
F	0031410	cellular_component	cytoplasmic vesicle
F	0042476	biological_process	odontogenesis
F	0042802	molecular_function	identical protein binding
F	0051289	biological_process	protein homotetramerization
F	0055085	biological_process	transmembrane transport
F	0070062	cellular_component	extracellular exosome
F	0071476	biological_process	cellular hypotonic response
G	0005515	molecular_function	protein binding
G	0005783	cellular_component	endoplasmic reticulum
G	0005886	cellular_component	plasma membrane
G	0005902	cellular_component	microvillus
G	0006833	biological_process	water transport
G	0009925	cellular_component	basal plasma membrane
G	0015250	molecular_function	water channel activity
G	0015267	molecular_function	channel activity
G	0015670	biological_process	carbon dioxide transport
G	0016020	cellular_component	membrane
G	0016324	cellular_component	apical plasma membrane
G	0030157	biological_process	pancreatic juice secretion
G	0030659	cellular_component	cytoplasmic vesicle membrane
G	0031410	cellular_component	cytoplasmic vesicle
G	0042476	biological_process	odontogenesis
G	0042802	molecular_function	identical protein binding
G	0051289	biological_process	protein homotetramerization
G	0055085	biological_process	transmembrane transport
G	0070062	cellular_component	extracellular exosome
G	0071476	biological_process	cellular hypotonic response
H	0005515	molecular_function	protein binding
H	0005783	cellular_component	endoplasmic reticulum
H	0005886	cellular_component	plasma membrane
H	0005902	cellular_component	microvillus
H	0006833	biological_process	water transport
H	0009925	cellular_component	basal plasma membrane
H	0015250	molecular_function	water channel activity
H	0015267	molecular_function	channel activity
H	0015670	biological_process	carbon dioxide transport
H	0016020	cellular_component	membrane
H	0016324	cellular_component	apical plasma membrane
H	0030157	biological_process	pancreatic juice secretion
H	0030659	cellular_component	cytoplasmic vesicle membrane
H	0031410	cellular_component	cytoplasmic vesicle
H	0042476	biological_process	odontogenesis
H	0042802	molecular_function	identical protein binding
H	0051289	biological_process	protein homotetramerization
H	0055085	biological_process	transmembrane transport
H	0070062	cellular_component	extracellular exosome
H	0071476	biological_process	cellular hypotonic response

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue PS6 D 301

Chain	Residue
A	VAL158
D	PRO157
D	VAL158
D	GLY159
D	LEU163
D	HOH411
D	HOH432
D	HOH438
A	GLY159
A	SER160
B	GLY159
B	SER160
C	GLY159
C	SER160
C	LEU163
C	HOH305

site_id	AC2
Number of Residues	14
Details	binding site for residue PS6 H 301

Chain	Residue
E	GLY159
E	SER160
F	GLY159
G	GLY159
G	SER160
G	LEU163
H	PRO157
H	VAL158
H	GLY159
H	SER160
H	HOH419
H	HOH423
H	HOH429
H	HOH464

Functional Information from PROSITE/UniProt

site_id	PS00221
Number of Residues	9
Details	MIP MIP family signature. HINPAITLA

Chain	Residue	Details
A	HIS67-ALA75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	960
Details	Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"18768791","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26569106","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	272
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"18768791","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26569106","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	208
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"18768791","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26569106","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	144
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"PubMed","id":"18768791","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26569106","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	16
Details	Motif: {"description":"NPA 1","evidences":[{"source":"PubMed","id":"18768791","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26569106","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	16
Details	Motif: {"description":"NPA 2","evidences":[{"source":"PubMed","id":"18768791","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26569106","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	16
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)