5C4U

Identification of a Novel Allosteric Binding Site for RORgt Inhibitors

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue 4Y7 A 601

Chain	Residue
A	TRP317
A	GLN484
A	GLN487
A	ALA496
A	ALA497
A	PHE498
A	LEU501
A	TYR502
A	LEU505
A	PHE506
A	LEU324
A	THR325
A	ILE328
A	GLN329
A	LEU353
A	LYS354
A	MET358
A	LEU483

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 602

Chain	Residue
A	GLY392
A	CYS393
A	SER394
A	GLU395
A	LEU396
A	LYS456
A	ARG482

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site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 603

Chain	Residue
A	GLN434
A	GLU435
A	LYS436
A	ARG437
A	LYS438

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site_id	AC4
Number of Residues	3
Details	binding site for residue GOL A 604

Chain	Residue
A	PHE388
A	LEU391
A	ILE397

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