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5C4T

Identification of a Novel Allosteric Binding Site for RORgt Inhibitors

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues20
Detailsbinding site for residue 4Y6 A 601
ChainResidue
ATRP317
AGLN484
AGLN487
AVAL494
AGLN495
AALA496
AALA497
APHE498
ALEU501
ATYR502
ALEU505
ALEU324
APHE506
ATHR325
AILE328
AGLN329
ALEU353
ALYS354
AMET358
ALEU483

site_idAC2
Number of Residues3
Detailsbinding site for residue SO4 A 602
ChainResidue
AGLN349
AILE350
ALEU353

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 603
ChainResidue
AGLN434
AGLU435
ALYS436
AARG437

site_idAC4
Number of Residues6
Detailsbinding site for residue GOL A 604
ChainResidue
AGLU271
AVAL274
ATRP314
AHIS453
ALYS456
ALEU489

site_idAC5
Number of Residues4
Detailsbinding site for residue GOL A 605
ChainResidue
AGLU304
AGLY307
ATYR308
ALYS311

site_idAC6
Number of Residues2
Detailsbinding site for residue GOL A 606
ChainResidue
ALYS354
ACYS476

site_idAC7
Number of Residues2
Detailsbinding site for residue GOL A 607
ChainResidue
AILE397
AILE400

site_idAC8
Number of Residues3
Detailsbinding site for residue GOL A 608
ChainResidue
AGLN441
ATYR444
AGLN460

site_idAC9
Number of Residues5
Detailsbinding site for residue GOL A 609
ChainResidue
AHIS323
APHE377
APHE378
AGLU379
AGLY380

site_idAD1
Number of Residues5
Detailsbinding site for residue GOL A 610
ChainResidue
AGLU318
AHIS322
AILE492
AVAL493
AHOH758

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PDB entries from 2024-11-06

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