5C37
Structure of the beta-ketoacyl reductase domain of human fatty acid synthase bound to a spiro-imidazolone inhibitor
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 26 |
| Details | binding site for residue NDP A 2201 |
| Chain | Residue |
| A | GLY1891 |
| A | ALA1972 |
| A | VAL1973 |
| A | VAL1974 |
| A | LYS1995 |
| A | PHE2019 |
| A | SER2020 |
| A | SER2021 |
| A | TYR2034 |
| A | TRP2060 |
| A | GLY2061 |
| A | GLY1894 |
| A | ILE2063 |
| A | GLY2067 |
| A | ILE2068 |
| A | LEU2069 |
| A | 4XN2202 |
| A | HOH2318 |
| A | HOH2364 |
| A | GLY1895 |
| A | PHE1896 |
| A | THR1915 |
| A | SER1916 |
| A | ARG1917 |
| A | ASN1945 |
| A | LEU1971 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | binding site for residue 4XN A 2202 |
| Chain | Residue |
| A | HIS1263 |
| A | PRO1264 |
| A | SER2021 |
| A | SER2023 |
| A | ARG2026 |
| A | GLY2027 |
| A | ASN2028 |
| A | TYR2034 |
| A | VAL2080 |
| A | SER2081 |
| A | PHE2109 |
| A | NDP2201 |
| A | HOH2358 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue CL A 2203 |
| Chain | Residue |
| A | ARG1461 |
| A | ARG1470 |
| A | HOH2339 |
| site_id | AC4 |
| Number of Residues | 27 |
| Details | binding site for residue NDP C 2201 |
| Chain | Residue |
| C | GLY1891 |
| C | GLY1894 |
| C | GLY1895 |
| C | PHE1896 |
| C | THR1915 |
| C | SER1916 |
| C | ARG1917 |
| C | SER1918 |
| C | ASN1945 |
| C | LEU1971 |
| C | ALA1972 |
| C | VAL1973 |
| C | LYS1995 |
| C | PHE2019 |
| C | SER2020 |
| C | SER2021 |
| C | TYR2034 |
| C | TRP2060 |
| C | GLY2061 |
| C | ILE2063 |
| C | GLY2067 |
| C | ILE2068 |
| C | 4XN2203 |
| C | HOH2321 |
| C | HOH2343 |
| C | HOH2350 |
| C | HOH2358 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 2202 |
| Chain | Residue |
| C | GLU1124 |
| C | PRO1222 |
| C | ALA1223 |
| C | PHE1517 |
| site_id | AC6 |
| Number of Residues | 14 |
| Details | binding site for residue 4XN C 2203 |
| Chain | Residue |
| C | HIS1263 |
| C | PRO1264 |
| C | SER2021 |
| C | VAL2022 |
| C | SER2023 |
| C | ARG2026 |
| C | GLY2027 |
| C | ASN2028 |
| C | TYR2034 |
| C | LEU2069 |
| C | VAL2080 |
| C | SER2081 |
| C | PHE2109 |
| C | NDP2201 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 2204 |
| Chain | Residue |
| C | ASN1234 |
| C | ARG1461 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CL C 2205 |
| Chain | Residue |
| C | HOH2422 |
| C | HOH2424 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"PubMed","id":"26851298","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
