5C13

Crystal Structure of TAF3 PHD finger bound to histone H3C4me3 peptide

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 1001

Chain	Residue
A	CYS885
A	CYS888
A	PHE910
A	CYS911
A	CYS914

---

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS870
A	CYS873
A	HIS893
A	CYS896

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN C 1001

Chain	Residue
C	CYS885
C	CYS888
C	PHE910
C	CYS911
C	CYS914

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN C 1002

Chain	Residue
C	CYS870
C	CYS873
C	HIS893
C	CYS896

---

site_id	AC5
Number of Residues	5
Details	binding site for residue ZN E 1001

Chain	Residue
E	CYS885
E	CYS888
E	PHE910
E	CYS911
E	CYS914

---

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN E 1002

Chain	Residue
E	CYS870
E	CYS873
E	HIS893
E	CYS896

---

site_id	AC7
Number of Residues	5
Details	binding site for residue ZN G 1001

Chain	Residue
G	CYS885
G	CYS888
G	PHE910
G	CYS911
G	CYS914

---

site_id	AC8
Number of Residues	4
Details	binding site for residue ZN G 1002

Chain	Residue
G	CYS870
G	CYS873
G	HIS893
G	CYS896

---

site_id	AC9
Number of Residues	8
Details	binding site for Ligand residues 4WQ D 4 through GLN D 5 bound to THR D 3

Chain	Residue
C	TRP868
C	PRO881
C	MET882
C	TRP891
D	THR3
D	THR6
G	TYR857
G	VAL858

---

site_id	AD1
Number of Residues	7
Details	binding site for Ligand residues 4WQ F 4 through GLN F 5 bound to THR F 3

Chain	Residue
A	TYR857
A	VAL858
A	ILE859
E	PRO881
E	MET882
F	THR3
F	THR6

---

site_id	AD2
Number of Residues	8
Details	binding site for Ligand residues 4WQ H 4 through GLN H 5 bound to THR H 3

Chain	Residue
C	TYR857
C	VAL858
C	ILE859
G	TRP868
G	PRO881
G	MET882
H	THR3
H	THR6

---

site_id	AD3
Number of Residues	9
Details	binding site for Ligand residues 4WQ P 4 through GLN P 5 bound to THR P 3

Chain	Residue
A	PRO881
A	MET882
A	TRP891
E	TYR857
E	VAL858
P	THR3
P	THR6
P	HOH101
P	HOH103

---

Functional Information from PROSITE/UniProt

site_id	PS01359
Number of Residues	45
Details	ZF_PHD_1 Zinc finger PHD-type signature. CpgCnkpddgspm....................................IgCdd..Cddw.YHwpCvgimtappeemq.................................WfCpkC

Chain	Residue	Details
A	CYS870-CYS914

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635

Chain	Residue	Details
P	ARG2
D	ARG2
F	ARG2
H	ARG2

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by HASPIN and VRK1 => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:31527692

Chain	Residue	Details
P	THR3
C	CYS873
C	CYS885
C	CYS888
C	HIS893
C	CYS896
C	CYS911
C	CYS914
E	CYS870
E	CYS873
E	CYS885
D	THR3
E	CYS888
E	HIS893
E	CYS896
E	CYS911
E	CYS914
G	CYS870
G	CYS873
G	CYS885
G	CYS888
G	HIS893
F	THR3
G	CYS896
G	CYS911
G	CYS914
H	THR3
A	HIS893
A	CYS896
A	CYS911
A	CYS914
C	CYS870

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	4WQ4
D	4WQ4
F	4WQ4
H	4WQ4

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594

Chain	Residue	Details
P	GLN5
D	GLN5
F	GLN5
H	GLN5

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790

Chain	Residue	Details
P	THR6
D	THR6
F	THR6
H	THR6

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433

Chain	Residue	Details
P	ARG8
D	ARG8
F	ARG8
H	ARG8

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708

Chain	Residue	Details
P	LYS9
D	LYS9
F	LYS9
H	LYS9

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588

Chain	Residue	Details
P	SER10
D	SER10
F	SER10
H	SER10

---