5C0Z
The structure of oxidized rat cytochrome c at 1.13 angstroms resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002931 | biological_process | response to ischemia |
| A | 0005758 | cellular_component | mitochondrial intermembrane space |
| A | 0005829 | cellular_component | cytosol |
| A | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| A | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| A | 0006979 | biological_process | response to oxidative stress |
| A | 0009055 | molecular_function | electron transfer activity |
| A | 0009629 | biological_process | response to gravity |
| A | 0010730 | biological_process | negative regulation of hydrogen peroxide biosynthetic process |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0020037 | molecular_function | heme binding |
| A | 0034349 | biological_process | glial cell apoptotic process |
| A | 0034465 | biological_process | response to carbon monoxide |
| A | 0046688 | biological_process | response to copper ion |
| A | 1901857 | biological_process | positive regulation of cellular respiration |
| B | 0002931 | biological_process | response to ischemia |
| B | 0005758 | cellular_component | mitochondrial intermembrane space |
| B | 0005829 | cellular_component | cytosol |
| B | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| B | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| B | 0006979 | biological_process | response to oxidative stress |
| B | 0009055 | molecular_function | electron transfer activity |
| B | 0009629 | biological_process | response to gravity |
| B | 0010730 | biological_process | negative regulation of hydrogen peroxide biosynthetic process |
| B | 0019899 | molecular_function | enzyme binding |
| B | 0020037 | molecular_function | heme binding |
| B | 0034349 | biological_process | glial cell apoptotic process |
| B | 0034465 | biological_process | response to carbon monoxide |
| B | 0046688 | biological_process | response to copper ion |
| B | 1901857 | biological_process | positive regulation of cellular respiration |
| C | 0002931 | biological_process | response to ischemia |
| C | 0005758 | cellular_component | mitochondrial intermembrane space |
| C | 0005829 | cellular_component | cytosol |
| C | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| C | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| C | 0006979 | biological_process | response to oxidative stress |
| C | 0009055 | molecular_function | electron transfer activity |
| C | 0009629 | biological_process | response to gravity |
| C | 0010730 | biological_process | negative regulation of hydrogen peroxide biosynthetic process |
| C | 0019899 | molecular_function | enzyme binding |
| C | 0020037 | molecular_function | heme binding |
| C | 0034349 | biological_process | glial cell apoptotic process |
| C | 0034465 | biological_process | response to carbon monoxide |
| C | 0046688 | biological_process | response to copper ion |
| C | 1901857 | biological_process | positive regulation of cellular respiration |
| D | 0002931 | biological_process | response to ischemia |
| D | 0005758 | cellular_component | mitochondrial intermembrane space |
| D | 0005829 | cellular_component | cytosol |
| D | 0006122 | biological_process | mitochondrial electron transport, ubiquinol to cytochrome c |
| D | 0006123 | biological_process | mitochondrial electron transport, cytochrome c to oxygen |
| D | 0006979 | biological_process | response to oxidative stress |
| D | 0009055 | molecular_function | electron transfer activity |
| D | 0009629 | biological_process | response to gravity |
| D | 0010730 | biological_process | negative regulation of hydrogen peroxide biosynthetic process |
| D | 0019899 | molecular_function | enzyme binding |
| D | 0020037 | molecular_function | heme binding |
| D | 0034349 | biological_process | glial cell apoptotic process |
| D | 0034465 | biological_process | response to carbon monoxide |
| D | 0046688 | biological_process | response to copper ion |
| D | 1901857 | biological_process | positive regulation of cellular respiration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue HEC A 201 |
| Chain | Residue |
| A | LYS13 |
| A | TYR48 |
| A | THR49 |
| A | ASN52 |
| A | TRP59 |
| A | TYR67 |
| A | THR78 |
| A | LYS79 |
| A | MET80 |
| A | ILE81 |
| A | PHE82 |
| A | CYS14 |
| A | HOH318 |
| A | CYS17 |
| A | HIS18 |
| A | THR28 |
| A | GLY29 |
| A | PRO30 |
| A | THR40 |
| A | GLY41 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue FC6 A 202 |
| Chain | Residue |
| A | LYS13 |
| A | GLY84 |
| A | ILE85 |
| A | LYS86 |
| A | LYS87 |
| A | HOH328 |
| A | HOH334 |
| A | HOH335 |
| A | HOH345 |
| D | LYS13 |
| D | ILE85 |
| D | LYS86 |
| D | LYS87 |
| D | HOH301 |
| D | HOH302 |
| D | HOH304 |
| D | HOH307 |
| D | HOH324 |
| D | HOH332 |
| D | HOH378 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | binding site for residue FC6 B 202 |
| Chain | Residue |
| A | LYS87 |
| A | LYS88 |
| A | GLY89 |
| A | GLU90 |
| B | LYS87 |
| B | LYS88 |
| B | GLY89 |
| B | GLU90 |
| B | HOH308 |
| site_id | AC4 |
| Number of Residues | 16 |
| Details | binding site for residue FC6 B 203 |
| Chain | Residue |
| B | LYS13 |
| B | ILE85 |
| B | LYS86 |
| B | LYS87 |
| B | HOH326 |
| B | HOH336 |
| C | LYS13 |
| C | ILE85 |
| C | LYS86 |
| C | LYS87 |
| C | HOH301 |
| C | HOH302 |
| C | HOH304 |
| C | HOH325 |
| C | HOH336 |
| C | HOH357 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | binding site for residue FC6 C 202 |
| Chain | Residue |
| C | LYS87 |
| C | LYS88 |
| C | GLY89 |
| C | HOH348 |
| C | HOH361 |
| C | HOH365 |
| C | HOH372 |
| C | HOH396 |
| C | HOH397 |
| D | LYS87 |
| D | LYS88 |
| D | GLY89 |
| D | HOH363 |
| D | HOH420 |
| site_id | AC6 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide HEC B 201 and CYS B 14 |
| Chain | Residue |
| B | HOH311 |
| B | HOH325 |
| B | PHE10 |
| B | LYS13 |
| B | ALA15 |
| B | GLN16 |
| B | CYS17 |
| B | HIS18 |
| B | THR28 |
| B | GLY29 |
| B | PRO30 |
| B | THR40 |
| B | GLY41 |
| B | TYR48 |
| B | THR49 |
| B | ASN52 |
| B | TRP59 |
| B | TYR67 |
| B | THR78 |
| B | LYS79 |
| B | MET80 |
| B | PHE82 |
| site_id | AC7 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide HEC B 201 and CYS B 17 |
| Chain | Residue |
| B | LYS13 |
| B | CYS14 |
| B | ALA15 |
| B | GLN16 |
| B | HIS18 |
| B | LYS27 |
| B | THR28 |
| B | GLY29 |
| B | PRO30 |
| B | THR40 |
| B | GLY41 |
| B | TYR48 |
| B | THR49 |
| B | ASN52 |
| B | TRP59 |
| B | TYR67 |
| B | THR78 |
| B | LYS79 |
| B | MET80 |
| B | PHE82 |
| B | HOH311 |
| B | HOH325 |
| C | ILE81 |
| site_id | AC8 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC C 201 and CYS C 17 |
| Chain | Residue |
| B | ILE81 |
| C | LYS13 |
| C | CYS14 |
| C | ALA15 |
| C | GLN16 |
| C | HIS18 |
| C | LYS27 |
| C | THR28 |
| C | GLY29 |
| C | PRO30 |
| C | THR40 |
| C | GLY41 |
| C | TYR48 |
| C | THR49 |
| C | ASN52 |
| C | TRP59 |
| C | TYR67 |
| C | THR78 |
| C | LYS79 |
| C | MET80 |
| C | ILE81 |
| C | PHE82 |
| C | HOH323 |
| C | HOH367 |
| site_id | AC9 |
| Number of Residues | 23 |
| Details | binding site for Di-peptide HEC C 201 and CYS C 14 |
| Chain | Residue |
| C | PHE10 |
| C | LYS13 |
| C | ALA15 |
| C | GLN16 |
| C | CYS17 |
| C | HIS18 |
| C | THR28 |
| C | GLY29 |
| C | PRO30 |
| C | THR40 |
| C | GLY41 |
| C | TYR48 |
| C | THR49 |
| C | ASN52 |
| C | TRP59 |
| C | TYR67 |
| C | THR78 |
| C | LYS79 |
| C | MET80 |
| C | ILE81 |
| C | PHE82 |
| C | HOH323 |
| C | HOH367 |
| site_id | AD1 |
| Number of Residues | 24 |
| Details | binding site for Di-peptide HEC D 201 and CYS D 17 |
| Chain | Residue |
| A | ILE81 |
| D | LYS13 |
| D | CYS14 |
| D | ALA15 |
| D | GLN16 |
| D | HIS18 |
| D | LYS27 |
| D | THR28 |
| D | GLY29 |
| D | PRO30 |
| D | THR40 |
| D | GLY41 |
| D | TYR48 |
| D | THR49 |
| D | ASN52 |
| D | TRP59 |
| D | TYR67 |
| D | THR78 |
| D | LYS79 |
| D | MET80 |
| D | ILE81 |
| D | PHE82 |
| D | HOH325 |
| D | HOH336 |
| site_id | AD2 |
| Number of Residues | 22 |
| Details | binding site for Di-peptide HEC D 201 and CYS D 14 |
| Chain | Residue |
| D | PHE10 |
| D | LYS13 |
| D | ALA15 |
| D | GLN16 |
| D | CYS17 |
| D | HIS18 |
| D | THR28 |
| D | PRO30 |
| D | THR40 |
| D | GLY41 |
| D | TYR48 |
| D | THR49 |
| D | ASN52 |
| D | TRP59 |
| D | TYR67 |
| D | THR78 |
| D | LYS79 |
| D | MET80 |
| D | ILE81 |
| D | PHE82 |
| D | HOH325 |
| D | HOH336 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"covalent"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"description":"axial binding residue"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N-acetylglycine","evidences":[{"source":"PubMed","id":"191069","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P62894","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P62897","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
