5C0O

m1A58 tRNA methyltransferase mutant - Y78A

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0005575	cellular_component	cellular_component
E	0008033	biological_process	tRNA processing
E	0008168	molecular_function	methyltransferase activity
E	0030488	biological_process	tRNA methylation
E	0031515	cellular_component	tRNA (m1A) methyltransferase complex
E	0032259	biological_process	methylation
E	0160107	molecular_function	tRNA (adenine(58)-N1)-methyltransferase activity
F	0005575	cellular_component	cellular_component
F	0008033	biological_process	tRNA processing
F	0008168	molecular_function	methyltransferase activity
F	0030488	biological_process	tRNA methylation
F	0031515	cellular_component	tRNA (m1A) methyltransferase complex
F	0032259	biological_process	methylation
F	0160107	molecular_function	tRNA (adenine(58)-N1)-methyltransferase activity
G	0005575	cellular_component	cellular_component
G	0008033	biological_process	tRNA processing
G	0008168	molecular_function	methyltransferase activity
G	0030488	biological_process	tRNA methylation
G	0031515	cellular_component	tRNA (m1A) methyltransferase complex
G	0032259	biological_process	methylation
G	0160107	molecular_function	tRNA (adenine(58)-N1)-methyltransferase activity
H	0005575	cellular_component	cellular_component
H	0008033	biological_process	tRNA processing
H	0008168	molecular_function	methyltransferase activity
H	0030488	biological_process	tRNA methylation
H	0031515	cellular_component	tRNA (m1A) methyltransferase complex
H	0032259	biological_process	methylation
H	0160107	molecular_function	tRNA (adenine(58)-N1)-methyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	21
Details	binding site for residue SAM E 301

Chain	Residue
E	ALA74
E	GLY106
E	LEU107
E	GLU125
E	ALA126
E	HIS130
E	GLY152
E	LYS153
E	LEU154
E	GLU155
E	ASP170
E	THR75
E	LEU171
E	HOH402
E	PRO76
E	THR77
E	GLY101
E	THR102
E	GLY103
E	SER104
E	GLY105

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site_id	AC2
Number of Residues	14
Details	binding site for residue SAM F 301

Chain	Residue
F	THR75
F	PRO76
F	THR77
F	GLY101
F	GLY103
F	GLY105
F	GLY106
F	LEU107
F	ALA126
F	HIS130
F	LYS153
F	ASP170
F	LEU171
F	HOH404

---

site_id	AC3
Number of Residues	8
Details	binding site for residue SO4 F 302

Chain	Residue
F	TRP226
F	GLU227
F	VAL228
F	ARG236
H	LEU215
H	GLU216
H	ARG217
H	VAL218

---

site_id	AC4
Number of Residues	21
Details	binding site for residue SAM G 301

Chain	Residue
G	ALA74
G	THR75
G	PRO76
G	THR77
G	GLY101
G	THR102
G	SER104
G	GLY105
G	GLY106
G	LEU107
G	GLU125
G	ALA126
G	ARG127
G	HIS130
G	GLY152
G	LYS153
G	LEU154
G	GLU155
G	ASP170
G	LEU171
G	HOH401

---

site_id	AC5
Number of Residues	19
Details	binding site for residue SAM H 301

Chain	Residue
H	PRO76
H	THR77
H	GLY101
H	THR102
H	GLY103
H	SER104
H	GLY105
H	GLY106
H	LEU107
H	GLU125
H	ALA126
H	ARG127
H	HIS130
H	LYS153
H	LEU154
H	GLU155
H	ASP170
H	LEU171
H	HOH412

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	BINDING:

Chain	Residue	Details
E	SER104
F	ASP170
G	SER104
G	GLU125
G	HIS130
G	GLU155
G	ASP170
H	SER104
H	GLU125
H	HIS130
H	GLU155
E	GLU125
H	ASP170
E	HIS130
E	GLU155
E	ASP170
F	SER104
F	GLU125
F	HIS130
F	GLU155

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