Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5C0C

1E6 TCR in complex with HLA-A02 carrying RQFGPDWIVA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0002250	biological_process	adaptive immune response
D	0005886	cellular_component	plasma membrane
D	0042101	cellular_component	T cell receptor complex
D	0042605	molecular_function	peptide antigen binding
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0032092	biological_process	positive regulation of protein binding
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1900121	biological_process	negative regulation of receptor binding
G	1900122	biological_process	positive regulation of receptor binding
G	1904434	biological_process	positive regulation of ferrous iron binding
G	1904437	biological_process	positive regulation of transferrin receptor binding
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
I	0002250	biological_process	adaptive immune response
I	0005886	cellular_component	plasma membrane
I	0042101	cellular_component	T cell receptor complex
I	0042605	molecular_function	peptide antigen binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue EDO A 301

Chain	Residue
A	PHE36
A	ASP37
A	ALA40
A	SER42
A	GLN43
A	ARG44
A	HOH413

site_id	AC2
Number of Residues	2
Details	binding site for residue EDO A 302

Chain	Residue
A	PRO20
A	HOH432

site_id	AC3
Number of Residues	7
Details	binding site for residue EDO A 303

Chain	Residue
A	ARG44
A	ASP61
A	THR64
A	ARG65
A	LYS68
J	EDO303
J	HOH416

site_id	AC4
Number of Residues	5
Details	binding site for residue PG4 A 304

Chain	Residue
A	ASP122
A	TYR123
A	THR134
A	ALA136
A	HOH448

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 305

Chain	Residue
A	ARG17
A	GLY18
A	HOH428
E	ARG22
E	PHE74

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO B 301

Chain	Residue
A	ARG234
A	GLN242
B	TYR10
B	SER11
B	HIS13
B	PRO14
B	HOH413

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO B 302

Chain	Residue
A	VAL12
B	ASP34
B	GOL303
B	HOH424

site_id	AC8
Number of Residues	6
Details	binding site for residue GOL B 303

Chain	Residue
A	ILE23
B	SER33
B	ASP34
B	ILE35
B	EDO302
B	HOH427

site_id	AC9
Number of Residues	4
Details	binding site for residue EDO D 301

Chain	Residue
D	GLY59
D	ARG60
D	ARG77
D	ASP78

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO D 302

Chain	Residue
D	ASP112
D	ILE113
D	ASP140
D	SER141
D	GLN142
D	HOH416

site_id	AD2
Number of Residues	3
Details	binding site for residue EDO D 303

Chain	Residue
D	GLY59
D	ARG60
D	PHE61

site_id	AD3
Number of Residues	5
Details	binding site for residue EDO E 301

Chain	Residue
D	ARG92
D	TYR97
D	LEU99
E	LEU100
E	ASN103

site_id	AD4
Number of Residues	8
Details	binding site for residue EDO E 302

Chain	Residue
E	ASP30
E	TYR31
E	LEU96
E	TRP97
E	GLU98
H	ILE8
H	VAL9
H	HOH104

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO E 303

Chain	Residue
E	GLN235
E	VAL237
E	HOH424

site_id	AD6
Number of Residues	3
Details	binding site for residue EDO E 304

Chain	Residue
E	PRO8
E	ARG9
E	HOH405

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO E 305

Chain	Residue
E	LEU116
E	GLU117
E	ASP118
E	ASN121
E	TYR153
E	ASP187

site_id	AD8
Number of Residues	2
Details	binding site for residue EDO E 306

Chain	Residue
E	HIS29
E	HOH403

site_id	AD9
Number of Residues	6
Details	binding site for residue EDO F 301

Chain	Residue
F	ARG44
F	ASP61
F	THR64
F	LYS68
F	HOH428
F	HOH430

site_id	AE1
Number of Residues	6
Details	binding site for residue EDO F 302

Chain	Residue
F	ASP122
F	ILE124
F	ALA125
F	THR134
F	ALA136
F	HOH461

site_id	AE2
Number of Residues	1
Details	binding site for residue EDO F 303

Chain	Residue
F	ARG21

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO F 304

Chain	Residue
F	ASP122
F	HOH424
F	TYR85
F	TYR118
F	LYS121

site_id	AE4
Number of Residues	3
Details	binding site for residue EDO F 305

Chain	Residue
F	TYR84
F	ALA139
F	THR142

site_id	AE5
Number of Residues	6
Details	binding site for residue EDO F 306

Chain	Residue
F	GLU19
F	PRO20
F	SER71
F	GLN72
F	ARG75
F	HOH447

site_id	AE6
Number of Residues	5
Details	binding site for residue EDO F 307

Chain	Residue
F	ARG44
F	MET45
F	TRP60
F	MET138
F	GLN141

site_id	AE7
Number of Residues	6
Details	binding site for residue GOL F 308

Chain	Residue
F	PRO50
F	GLU53
F	GLN54
F	LYS127
F	SER132
F	TRP133

site_id	AE8
Number of Residues	6
Details	binding site for residue GOL F 309

Chain	Residue
F	SER4
F	ARG6
F	PHE8
F	TYR27
F	ASP29
F	HOH496

site_id	AE9
Number of Residues	8
Details	binding site for residue EDO G 101

Chain	Residue
F	LEU206
F	ARG234
F	GLN242
G	TYR10
G	SER11
G	HIS13
G	PRO14
G	HOH217

site_id	AF1
Number of Residues	3
Details	binding site for residue EDO G 102

Chain	Residue
F	HOH510
G	SER33
G	ASP34

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO I 301

Chain	Residue
D	ASP66
D	TYR71
I	LEU11
I	SER12

site_id	AF3
Number of Residues	4
Details	binding site for residue EDO I 302

Chain	Residue
D	ARG77
I	ARG77
I	HOH422
I	HOH444

site_id	AF4
Number of Residues	5
Details	binding site for residue EDO I 303

Chain	Residue
I	GLU3
I	GLU5
I	THR24
I	TYR25
I	SER26

site_id	AF5
Number of Residues	12
Details	binding site for residue PG4 I 304

Chain	Residue
D	PRO10
D	SER12
D	VAL13
D	ILE18
D	VAL19
D	SER20
I	GLN64
I	ASP66
I	SER69
I	TYR71
I	HOH429
I	HOH432

site_id	AF6
Number of Residues	5
Details	binding site for residue EDO J 301

Chain	Residue
I	ARG92
I	TYR97
I	LEU99
J	LEU100
J	ASN103

site_id	AF7
Number of Residues	6
Details	binding site for residue EDO J 302

Chain	Residue
J	LEU116
J	GLU117
J	ASP118
J	ASN121
J	TYR153
J	ASP187

site_id	AF8
Number of Residues	5
Details	binding site for residue EDO J 303

Chain	Residue
A	EDO303
J	PRO54
J	ILE55
J	ASP56
J	ASP57

site_id	AF9
Number of Residues	3
Details	binding site for residue EDO J 304

Chain	Residue
J	GLY3
J	VAL4
J	PHE107

site_id	AG1
Number of Residues	3
Details	binding site for residue EDO J 305

Chain	Residue
J	VAL168
J	HIS169
J	SER170

site_id	AG2
Number of Residues	2
Details	binding site for residue EDO J 306

Chain	Residue
J	ARG85
J	LYS102

site_id	AG3
Number of Residues	8
Details	binding site for residue EDO J 307

Chain	Residue
C	ILE8
C	VAL9
C	HOH105
J	ASP30
J	TYR31
J	LEU96
J	TRP97
J	GLU98

site_id	AG4
Number of Residues	5
Details	binding site for residue SO4 J 308

Chain	Residue
F	ARG17
F	GLY18
J	ARG22
J	PHE74
J	HOH486

site_id	AG5
Number of Residues	5
Details	binding site for residue SO4 J 309

Chain	Residue
A	HIS151
A	GLN155
A	HOH435
J	ALA101
J	LYS102

site_id	AG6
Number of Residues	6
Details	binding site for residue SO4 J 310

Chain	Residue
G	ARG45
G	GLU47
G	HOH205
J	GLU221
J	LYS231
J	HOH454

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
E	ASN186
F	THR143
F	LYS146
F	TYR171
J	ASN186
A	TYR84
A	THR143
A	LYS146
A	TYR171
F	TYR7
F	THR73
F	TYR84

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN71
J	ASN71
I	ASN144
I	ASN178

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
D	ASN189
G	LYS58
G	LYS91
G	LYS94
I	ASN189
B	LYS48
B	LYS58
B	LYS91
B	LYS94
G	LYS19
G	LYS41
G	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
F	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)