5C0A
1E6 TCR in complex with HLA-A02 carrying MVW peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000139 | cellular_component | Golgi membrane |
| B | 0002376 | biological_process | immune system process |
| B | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| B | 0002477 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| B | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| B | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| B | 0002715 | biological_process | regulation of natural killer cell mediated immunity |
| B | 0002726 | biological_process | positive regulation of T cell cytokine production |
| B | 0005198 | molecular_function | structural molecule activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005576 | cellular_component | extracellular region |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005765 | cellular_component | lysosomal membrane |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005788 | cellular_component | endoplasmic reticulum lumen |
| B | 0005794 | cellular_component | Golgi apparatus |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0005925 | cellular_component | focal adhesion |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0006955 | biological_process | immune response |
| B | 0007608 | biological_process | sensory perception of smell |
| B | 0007611 | biological_process | learning or memory |
| B | 0009897 | cellular_component | external side of plasma membrane |
| B | 0009986 | cellular_component | cell surface |
| B | 0010038 | biological_process | response to metal ion |
| B | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| B | 0016020 | cellular_component | membrane |
| B | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| B | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| B | 0023026 | molecular_function | MHC class II protein complex binding |
| B | 0030670 | cellular_component | phagocytic vesicle membrane |
| B | 0031901 | cellular_component | early endosome membrane |
| B | 0031902 | cellular_component | late endosome membrane |
| B | 0031905 | cellular_component | early endosome lumen |
| B | 0033572 | biological_process | transferrin transport |
| B | 0034756 | biological_process | regulation of iron ion transport |
| B | 0034757 | biological_process | negative regulation of iron ion transport |
| B | 0035580 | cellular_component | specific granule lumen |
| B | 0042605 | molecular_function | peptide antigen binding |
| B | 0042612 | cellular_component | MHC class I protein complex |
| B | 0042613 | cellular_component | MHC class II protein complex |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0042824 | cellular_component | MHC class I peptide loading complex |
| B | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| B | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| B | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| B | 0050768 | biological_process | negative regulation of neurogenesis |
| B | 0050778 | biological_process | positive regulation of immune response |
| B | 0050870 | biological_process | positive regulation of T cell activation |
| B | 0051289 | biological_process | protein homotetramerization |
| B | 0055038 | cellular_component | recycling endosome membrane |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0071281 | biological_process | cellular response to iron ion |
| B | 0071316 | biological_process | cellular response to nicotine |
| B | 1904724 | cellular_component | tertiary granule lumen |
| B | 1990000 | biological_process | amyloid fibril formation |
| B | 1990712 | cellular_component | HFE-transferrin receptor complex |
| B | 2000774 | biological_process | positive regulation of cellular senescence |
| B | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| D | 0002250 | biological_process | adaptive immune response |
| D | 0002376 | biological_process | immune system process |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0042101 | cellular_component | T cell receptor complex |
| D | 0042605 | molecular_function | peptide antigen binding |
| G | 0000139 | cellular_component | Golgi membrane |
| G | 0002376 | biological_process | immune system process |
| G | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| G | 0002477 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class Ib |
| G | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| G | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| G | 0002715 | biological_process | regulation of natural killer cell mediated immunity |
| G | 0002726 | biological_process | positive regulation of T cell cytokine production |
| G | 0005198 | molecular_function | structural molecule activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005576 | cellular_component | extracellular region |
| G | 0005615 | cellular_component | extracellular space |
| G | 0005765 | cellular_component | lysosomal membrane |
| G | 0005783 | cellular_component | endoplasmic reticulum |
| G | 0005788 | cellular_component | endoplasmic reticulum lumen |
| G | 0005794 | cellular_component | Golgi apparatus |
| G | 0005886 | cellular_component | plasma membrane |
| G | 0005925 | cellular_component | focal adhesion |
| G | 0006879 | biological_process | intracellular iron ion homeostasis |
| G | 0006955 | biological_process | immune response |
| G | 0007608 | biological_process | sensory perception of smell |
| G | 0007611 | biological_process | learning or memory |
| G | 0009897 | cellular_component | external side of plasma membrane |
| G | 0009986 | cellular_component | cell surface |
| G | 0010038 | biological_process | response to metal ion |
| G | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| G | 0016020 | cellular_component | membrane |
| G | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| G | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| G | 0023026 | molecular_function | MHC class II protein complex binding |
| G | 0030670 | cellular_component | phagocytic vesicle membrane |
| G | 0031901 | cellular_component | early endosome membrane |
| G | 0031902 | cellular_component | late endosome membrane |
| G | 0031905 | cellular_component | early endosome lumen |
| G | 0033572 | biological_process | transferrin transport |
| G | 0034756 | biological_process | regulation of iron ion transport |
| G | 0034757 | biological_process | negative regulation of iron ion transport |
| G | 0035580 | cellular_component | specific granule lumen |
| G | 0042605 | molecular_function | peptide antigen binding |
| G | 0042612 | cellular_component | MHC class I protein complex |
| G | 0042613 | cellular_component | MHC class II protein complex |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0042803 | molecular_function | protein homodimerization activity |
| G | 0042824 | cellular_component | MHC class I peptide loading complex |
| G | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| G | 0048261 | biological_process | negative regulation of receptor-mediated endocytosis |
| G | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| G | 0050768 | biological_process | negative regulation of neurogenesis |
| G | 0050778 | biological_process | positive regulation of immune response |
| G | 0050870 | biological_process | positive regulation of T cell activation |
| G | 0051289 | biological_process | protein homotetramerization |
| G | 0055038 | cellular_component | recycling endosome membrane |
| G | 0070062 | cellular_component | extracellular exosome |
| G | 0071281 | biological_process | cellular response to iron ion |
| G | 0071316 | biological_process | cellular response to nicotine |
| G | 1904724 | cellular_component | tertiary granule lumen |
| G | 1990000 | biological_process | amyloid fibril formation |
| G | 1990712 | cellular_component | HFE-transferrin receptor complex |
| G | 2000774 | biological_process | positive regulation of cellular senescence |
| G | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
| I | 0002250 | biological_process | adaptive immune response |
| I | 0002376 | biological_process | immune system process |
| I | 0005886 | cellular_component | plasma membrane |
| I | 0042101 | cellular_component | T cell receptor complex |
| I | 0042605 | molecular_function | peptide antigen binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 301 |
| Chain | Residue |
| A | SER11 |
| A | PRO20 |
| A | PHE22 |
| A | SER71 |
| A | GLN72 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 302 |
| Chain | Residue |
| A | GLN43 |
| A | ARG44 |
| A | GLU46 |
| A | PHE36 |
| A | ASP37 |
| A | ALA40 |
| A | SER42 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | SER13 |
| A | ARG14 |
| A | ARG17 |
| A | GLY18 |
| A | GLU19 |
| A | PRO20 |
| A | HOH401 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue GOL B 101 |
| Chain | Residue |
| A | VAL12 |
| A | ARG21 |
| A | HOH410 |
| B | SER33 |
| B | ASP34 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO D 201 |
| Chain | Residue |
| D | ARG92 |
| D | TYR97 |
| D | LEU99 |
| E | ASN103 |
| E | GLN105 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO D 202 |
| Chain | Residue |
| D | ARG77 |
| I | ILE18 |
| I | ARG77 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 D 203 |
| Chain | Residue |
| D | LEU11 |
| D | SER12 |
| D | VAL13 |
| I | ASP66 |
| I | TYR71 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | binding site for residue EDO E 301 |
| Chain | Residue |
| E | ALA2 |
| E | GLY3 |
| E | LYS24 |
| E | PRO25 |
| E | ILE26 |
| E | SER27 |
| F | GLU89 |
| site_id | AC9 |
| Number of Residues | 2 |
| Details | binding site for residue SO4 E 302 |
| Chain | Residue |
| E | HIS169 |
| E | SER170 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 E 303 |
| Chain | Residue |
| E | ARG85 |
| E | LYS102 |
| E | HOH417 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 E 304 |
| Chain | Residue |
| E | ARG22 |
| F | ARG17 |
| F | GLY18 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue GOL F 301 |
| Chain | Residue |
| F | GLN43 |
| F | LYS68 |
| site_id | AD4 |
| Number of Residues | 8 |
| Details | binding site for residue GOL F 302 |
| Chain | Residue |
| F | SER13 |
| F | LEU78 |
| F | ARG82 |
| F | SER88 |
| F | GLU89 |
| F | GLY91 |
| F | HIS93 |
| F | TYR118 |
| site_id | AD5 |
| Number of Residues | 7 |
| Details | binding site for residue EDO F 303 |
| Chain | Residue |
| F | PHE36 |
| F | ASP37 |
| F | ALA40 |
| F | SER42 |
| F | GLN43 |
| F | ARG44 |
| F | GLU46 |
| site_id | AD6 |
| Number of Residues | 5 |
| Details | binding site for residue EDO F 304 |
| Chain | Residue |
| F | ARG44 |
| F | ASP61 |
| F | THR64 |
| F | LYS68 |
| J | HOH403 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO F 305 |
| Chain | Residue |
| F | LYS146 |
| F | HOH415 |
| H | TYR9 |
| site_id | AD8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 F 306 |
| Chain | Residue |
| F | ARG6 |
| F | PHE8 |
| F | TYR27 |
| F | ASP29 |
| F | ASP30 |
| site_id | AD9 |
| Number of Residues | 7 |
| Details | binding site for residue GOL G 101 |
| Chain | Residue |
| F | LEU206 |
| F | GLN242 |
| G | TYR10 |
| G | SER11 |
| G | ARG12 |
| G | HIS13 |
| G | PRO14 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 G 102 |
| Chain | Residue |
| E | GLU221 |
| E | LYS231 |
| G | ARG45 |
| G | GLU47 |
| G | LYS48 |
| site_id | AE2 |
| Number of Residues | 8 |
| Details | binding site for residue EDO H 101 |
| Chain | Residue |
| J | ASP30 |
| J | TYR31 |
| J | TRP97 |
| F | THR73 |
| H | PRO7 |
| H | LEU8 |
| H | TYR9 |
| H | HOH202 |
| site_id | AE3 |
| Number of Residues | 10 |
| Details | binding site for residue EDO H 102 |
| Chain | Residue |
| F | GLN155 |
| H | TRP3 |
| H | GLY4 |
| H | PRO5 |
| H | ASP6 |
| H | HOH201 |
| H | HOH204 |
| I | TYR97 |
| J | TRP97 |
| J | ALA101 |
| site_id | AE4 |
| Number of Residues | 7 |
| Details | binding site for residue EDO I 201 |
| Chain | Residue |
| D | ARG110 |
| D | GLN142 |
| I | SER53 |
| I | VAL65 |
| I | ASP66 |
| I | LYS67 |
| I | SER68 |
| site_id | AE5 |
| Number of Residues | 4 |
| Details | binding site for residue GOL J 301 |
| Chain | Residue |
| A | ARG17 |
| A | GLY18 |
| J | ARG22 |
| J | PHE74 |
| site_id | AE6 |
| Number of Residues | 6 |
| Details | binding site for residue EDO J 302 |
| Chain | Residue |
| I | ARG92 |
| I | TYR97 |
| I | LEU99 |
| J | LEU100 |
| J | ASN103 |
| J | GLN105 |
| site_id | AE7 |
| Number of Residues | 7 |
| Details | binding site for residue EDO J 303 |
| Chain | Residue |
| J | HIS29 |
| J | ASP30 |
| J | ASN51 |
| J | ASN52 |
| J | MET69 |
| J | ALA72 |
| J | HOH412 |
| site_id | AE8 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 J 304 |
| Chain | Residue |
| J | PRO61 |
| J | GLU62 |
| J | ASP63 |
| J | ARG64 |
| J | ARG85 |
Functional Information from PROSITE/UniProt
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH |
| Chain | Residue | Details |
| B | TYR78-HIS84 | |
| A | TYR257-HIS263 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 172 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 178 |
| Details | Region: {"description":"Alpha-1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 182 |
| Details | Region: {"description":"Alpha-2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 182 |
| Details | Region: {"description":"Alpha-3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21943705","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"21543847","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Sulfotyrosine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 176 |
| Details | Domain: {"description":"Ig-like C1-type"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Pyrrolidone carboxylic acid; in form pI 5.3","evidences":[{"source":"PubMed","id":"7554280","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI12 |
| Number of Residues | 12 |
| Details | Glycosylation: {"description":"N-linked (Glc) (glycation) lysine; in vitro","evidences":[{"source":"PubMed","id":"7918443","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI13 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI14 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"19349973","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI16 |
| Number of Residues | 186 |
| Details | Domain: {"description":"Ig-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI17 |
| Number of Residues | 218 |
| Details | Domain: {"description":"Ig-like C1-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
