Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5C08

1E6 TCR in Complex with HLA-A0e carrying RQWGPDPAAV

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0002250	biological_process	adaptive immune response
D	0005886	cellular_component	plasma membrane
D	0042101	cellular_component	T cell receptor complex
D	0042605	molecular_function	peptide antigen binding
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0032092	biological_process	positive regulation of protein binding
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1900121	biological_process	negative regulation of receptor binding
G	1900122	biological_process	positive regulation of receptor binding
G	1904434	biological_process	positive regulation of ferrous iron binding
G	1904437	biological_process	positive regulation of transferrin receptor binding
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
I	0002250	biological_process	adaptive immune response
I	0005886	cellular_component	plasma membrane
I	0042101	cellular_component	T cell receptor complex
I	0042605	molecular_function	peptide antigen binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue EDO A 301

Chain	Residue
A	ARG21
B	HIS51

site_id	AC2
Number of Residues	6
Details	binding site for residue EDO A 302

Chain	Residue
A	TYR85
A	GLN87
A	TYR118
A	ASP119
A	LYS121
B	MET0

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 303

Chain	Residue
A	ARG6
A	PHE8
A	TYR27
A	ASP29
A	SER4

site_id	AC4
Number of Residues	6
Details	binding site for residue EDO B 301

Chain	Residue
A	ARG234
A	GLN242
B	SER11
B	HIS13
B	PRO14
B	MET99

site_id	AC5
Number of Residues	7
Details	binding site for residue EDO B 302

Chain	Residue
B	ARG45
B	GLU47
B	LYS48
B	HOH405
J	SER220
J	GLU221
J	LYS231

site_id	AC6
Number of Residues	7
Details	binding site for residue EDO B 303

Chain	Residue
A	ILE23
A	ARG35
A	ASP37
B	HIS51
B	SER52
B	ASP53
B	LEU54

site_id	AC7
Number of Residues	4
Details	binding site for residue EDO C 101

Chain	Residue
A	LYS146
C	ALA9
E	TRP97
E	GLU98

site_id	AC8
Number of Residues	2
Details	binding site for residue EDO D 201

Chain	Residue
D	ARG77
I	ARG77

site_id	AC9
Number of Residues	2
Details	binding site for residue GOL D 202

Chain	Residue
D	ARG60
D	PHE61

site_id	AD1
Number of Residues	2
Details	binding site for residue SO4 D 203

Chain	Residue
D	TYR49
D	LYS56

site_id	AD2
Number of Residues	5
Details	binding site for residue SO4 D 204

Chain	Residue
D	GLU5
D	ASP7
D	ASN22
D	CYS23
D	THR24

site_id	AD3
Number of Residues	4
Details	binding site for residue EDO E 301

Chain	Residue
E	ASN164
E	GLY165
E	ARG211
G	SER88

site_id	AD4
Number of Residues	4
Details	binding site for residue EDO E 302

Chain	Residue
E	ARG22
E	PHE74
F	ARG17
F	GLY18

site_id	AD5
Number of Residues	2
Details	binding site for residue EDO E 303

Chain	Residue
E	PRO84
E	ARG85

site_id	AD6
Number of Residues	7
Details	binding site for residue EDO E 304

Chain	Residue
D	MET34
D	TYR36
D	ARG92
D	TYR97
D	LEU99
E	ASN103
E	GLN105

site_id	AD7
Number of Residues	3
Details	binding site for residue EDO E 305

Chain	Residue
E	PRO8
E	ARG9
E	HIS10

site_id	AD8
Number of Residues	7
Details	binding site for residue GOL E 306

Chain	Residue
A	THR73
C	PRO7
C	ALA9
E	ASP30
E	TYR31
E	ASN50
E	ASN51

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 E 307

Chain	Residue
A	LYS68
E	PRO54
E	ILE55
E	ASP57

site_id	AE1
Number of Residues	3
Details	binding site for residue SO4 E 308

Chain	Residue
E	ASP57
E	SER66
E	ALA67

site_id	AE2
Number of Residues	3
Details	binding site for residue EDO F 301

Chain	Residue
F	SER4
F	ARG6
F	ASP29

site_id	AE3
Number of Residues	4
Details	binding site for residue EDO F 302

Chain	Residue
F	THR73
J	TYR31
J	ASN50
J	TRP97

site_id	AE4
Number of Residues	6
Details	binding site for residue EDO F 303

Chain	Residue
F	TYR116
F	ASP122
F	TYR123
F	ILE124
F	ALA125
G	TRP60

site_id	AE5
Number of Residues	4
Details	binding site for residue EDO F 304

Chain	Residue
F	ARG14
F	ARG17
F	ARG21
G	ASP34

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 F 305

Chain	Residue
F	ARG48
F	ALA49
F	PRO50
F	GLU53

site_id	AE7
Number of Residues	5
Details	binding site for residue EDO G 101

Chain	Residue
F	ASP37
G	HIS51
G	SER52
G	ASP53
G	LEU54

site_id	AE8
Number of Residues	4
Details	binding site for residue EDO I 201

Chain	Residue
D	SER69
D	TYR71
I	PRO10
I	SER12

site_id	AE9
Number of Residues	3
Details	binding site for residue EDO I 202

Chain	Residue
I	LEU47
I	MET48
I	ASP58

site_id	AF1
Number of Residues	3
Details	binding site for residue EDO I 203

Chain	Residue
I	GLY59
I	ARG60
I	PHE61

site_id	AF2
Number of Residues	4
Details	binding site for residue EDO I 204

Chain	Residue
D	PRO10
D	SER12
I	SER69
I	TYR71

site_id	AF3
Number of Residues	5
Details	binding site for residue EDO I 205

Chain	Residue
D	TYR71
I	VAL13
I	ILE18
I	VAL19
I	SER20

site_id	AF4
Number of Residues	4
Details	binding site for residue EDO J 301

Chain	Residue
J	ARG41
J	MET60
J	PRO61
J	EDO303

site_id	AF5
Number of Residues	6
Details	binding site for residue EDO J 302

Chain	Residue
I	ARG92
I	TYR97
I	LEU99
J	LEU100
J	ASN103
J	GLN105

site_id	AF6
Number of Residues	5
Details	binding site for residue EDO J 303

Chain	Residue
J	ARG36
J	ARG64
J	PHE65
J	ASP86
J	EDO301

site_id	AF7
Number of Residues	2
Details	binding site for residue SO4 J 304

Chain	Residue
J	ARG85
J	LYS102

site_id	AF8
Number of Residues	1
Details	binding site for residue SO4 J 305

Chain	Residue
J	ILE104

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
E	ASN186
F	THR143
F	LYS146
F	TYR171
J	ASN186
A	TYR84
A	THR143
A	LYS146
A	TYR171
F	TYR7
F	THR73
F	TYR84

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN71
J	ASN71
I	ASN144
I	ASN178

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
D	ASN189
G	LYS58
G	LYS91
G	LYS94
I	ASN189
B	LYS48
B	LYS58
B	LYS91
B	LYS94
G	LYS19
G	LYS41
G	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
F	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)