Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5C07

1E6 TCR in complex with HLA-A02 carrying YQFGPDFPIA

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0002250	biological_process	adaptive immune response
D	0002376	biological_process	immune system process
D	0005886	cellular_component	plasma membrane
D	0016020	cellular_component	membrane
D	0042101	cellular_component	T cell receptor complex
D	0042605	molecular_function	peptide antigen binding
G	0000139	cellular_component	Golgi membrane
G	0001913	biological_process	T cell mediated cytotoxicity
G	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
G	0002237	biological_process	response to molecule of bacterial origin
G	0002376	biological_process	immune system process
G	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
G	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
G	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
G	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
G	0002726	biological_process	positive regulation of T cell cytokine production
G	0005198	molecular_function	structural molecule activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005765	cellular_component	lysosomal membrane
G	0005783	cellular_component	endoplasmic reticulum
G	0005788	cellular_component	endoplasmic reticulum lumen
G	0005794	cellular_component	Golgi apparatus
G	0005829	cellular_component	cytosol
G	0005886	cellular_component	plasma membrane
G	0005925	cellular_component	focal adhesion
G	0006826	biological_process	iron ion transport
G	0006879	biological_process	intracellular iron ion homeostasis
G	0006955	biological_process	immune response
G	0007608	biological_process	sensory perception of smell
G	0007611	biological_process	learning or memory
G	0009897	cellular_component	external side of plasma membrane
G	0009986	cellular_component	cell surface
G	0010977	biological_process	negative regulation of neuron projection development
G	0012507	cellular_component	ER to Golgi transport vesicle membrane
G	0016020	cellular_component	membrane
G	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
G	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
G	0023026	molecular_function	MHC class II protein complex binding
G	0030670	cellular_component	phagocytic vesicle membrane
G	0031901	cellular_component	early endosome membrane
G	0031902	cellular_component	late endosome membrane
G	0031905	cellular_component	early endosome lumen
G	0032092	biological_process	positive regulation of protein binding
G	0033077	biological_process	T cell differentiation in thymus
G	0034756	biological_process	regulation of iron ion transport
G	0035580	cellular_component	specific granule lumen
G	0042026	biological_process	protein refolding
G	0042605	molecular_function	peptide antigen binding
G	0042612	cellular_component	MHC class I protein complex
G	0042613	cellular_component	MHC class II protein complex
G	0042802	molecular_function	identical protein binding
G	0042803	molecular_function	protein homodimerization activity
G	0042824	cellular_component	MHC class I peptide loading complex
G	0045646	biological_process	regulation of erythrocyte differentiation
G	0048260	biological_process	positive regulation of receptor-mediated endocytosis
G	0050680	biological_process	negative regulation of epithelial cell proliferation
G	0050768	biological_process	negative regulation of neurogenesis
G	0050778	biological_process	positive regulation of immune response
G	0050870	biological_process	positive regulation of T cell activation
G	0051289	biological_process	protein homotetramerization
G	0055038	cellular_component	recycling endosome membrane
G	0060586	biological_process	multicellular organismal-level iron ion homeostasis
G	0070062	cellular_component	extracellular exosome
G	0071281	biological_process	cellular response to iron ion
G	0071283	biological_process	cellular response to iron(III) ion
G	0071316	biological_process	cellular response to nicotine
G	1900121	biological_process	negative regulation of receptor binding
G	1900122	biological_process	positive regulation of receptor binding
G	1904434	biological_process	positive regulation of ferrous iron binding
G	1904437	biological_process	positive regulation of transferrin receptor binding
G	1904724	cellular_component	tertiary granule lumen
G	1990000	biological_process	amyloid fibril formation
G	1990712	cellular_component	HFE-transferrin receptor complex
G	2000774	biological_process	positive regulation of cellular senescence
G	2000978	biological_process	negative regulation of forebrain neuron differentiation
I	0002250	biological_process	adaptive immune response
I	0002376	biological_process	immune system process
I	0005886	cellular_component	plasma membrane
I	0016020	cellular_component	membrane
I	0042101	cellular_component	T cell receptor complex
I	0042605	molecular_function	peptide antigen binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 301

Chain	Residue
A	GLU19
A	PRO20
A	SER38
A	SER71
A	ARG75
A	HOH444
A	HOH472

site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
B	EDO101
A	ARG21
B	HIS51

site_id	AC3
Number of Residues	5
Details	binding site for residue EDO B 101

Chain	Residue
A	ARG21
A	SO4302
B	SER33
B	ASP34
B	HOH206

site_id	AC4
Number of Residues	5
Details	binding site for residue EDO D 301

Chain	Residue
D	ARG92
D	TYR97
D	LEU99
E	LEU100
E	ASN103

site_id	AC5
Number of Residues	2
Details	binding site for residue SO4 D 302

Chain	Residue
D	ARG60
D	HOH436

site_id	AC6
Number of Residues	9
Details	binding site for residue EDO E 301

Chain	Residue
C	PRO8
C	ILE9
E	ASP30
E	TYR31
E	LEU96
E	TRP97
E	GLU98
E	HOH426
E	HOH460

site_id	AC7
Number of Residues	5
Details	binding site for residue GOL F 301

Chain	Residue
F	GLN43
F	LYS68
F	GLN72
J	VAL53
J	HOH433

site_id	AC8
Number of Residues	7
Details	binding site for residue GOL F 302

Chain	Residue
F	SER13
F	LEU78
F	SER88
F	GLU89
F	GLY91
F	HIS93
F	TYR118

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL F 303

Chain	Residue
E	ALA2
E	GLY3
E	SER27
F	GLU89
F	HOH437
F	HOH442

site_id	AD1
Number of Residues	6
Details	binding site for residue EDO F 304

Chain	Residue
F	GLU19
F	PRO20
F	SER71
F	GLN72
F	ARG75
F	HOH408

site_id	AD2
Number of Residues	6
Details	binding site for residue SO4 F 305

Chain	Residue
F	ASP122
F	TYR123
F	ILE124
F	ALA125
F	THR134
F	ALA136

site_id	AD3
Number of Residues	3
Details	binding site for residue EDO G 101

Chain	Residue
G	SER33
G	ASP34
G	HOH223

site_id	AD4
Number of Residues	6
Details	binding site for residue EDO G 102

Chain	Residue
F	ARG234
F	GLN242
G	TYR10
G	SER11
G	TRP95
G	MET99

site_id	AD5
Number of Residues	11
Details	binding site for residue GOL H 101

Chain	Residue
F	GLN155
H	PHE3
H	GLY4
H	PRO5
H	ASP6
I	TYR32
I	ARG92
I	TYR97
I	HOH417
J	TRP97
J	ALA101

site_id	AD6
Number of Residues	5
Details	binding site for residue GOL I 301

Chain	Residue
D	SER12
D	VAL13
I	ASP66
I	SER69
I	TYR71

site_id	AD7
Number of Residues	4
Details	binding site for residue EDO I 302

Chain	Residue
I	ARG92
I	TYR97
I	LEU99
J	ASN103

site_id	AD8
Number of Residues	4
Details	binding site for residue EDO I 303

Chain	Residue
D	ASP66
D	TYR71
I	SER12
I	VAL13

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 I 304

Chain	Residue
D	ILE18
D	ARG77
I	ILE18
I	ARG77
I	HOH408

site_id	AE1
Number of Residues	8
Details	binding site for residue GOL J 301

Chain	Residue
H	PHE7
H	PRO8
H	ILE9
J	ASP30
J	TYR31
J	LEU96
J	TRP97
J	HOH429

site_id	AE2
Number of Residues	8
Details	binding site for residue GOL J 302

Chain	Residue
A	GLU89
A	HOH478
J	ALA2
J	GLY3
J	LYS24
J	PRO25
J	ILE26
J	SER27

site_id	AE3
Number of Residues	5
Details	binding site for residue EDO J 303

Chain	Residue
J	ARG36
J	ARG41
J	ARG64
J	ARG85
J	ASP86

site_id	AE4
Number of Residues	4
Details	binding site for residue SO4 J 304

Chain	Residue
F	HIS151
J	ARG85
J	LYS102
J	HOH408

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
E	ASN71
F	THR143
F	LYS146
F	TYR171
J	ASN71
A	TYR84
A	THR143
A	LYS146
A	TYR171
F	TYR7
F	THR73
F	TYR84

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
E	ASN186
J	ASN186
I	ASN144
I	ASN178

site_id	SWS_FT_FI3
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255\|PROSITE-ProRule:PRU00498

Chain	Residue	Details
D	ASN189
G	LYS58
G	LYS91
G	LYS94
I	ASN189
B	LYS48
B	LYS58
B	LYS91
B	LYS94
G	LYS19
G	LYS41
G	LYS48

site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:19159218

Chain	Residue	Details
A	ASN86
F	ASN86

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)