5BTL

Crystal structure of a topoisomerase II complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
A	0005524	molecular_function	ATP binding
A	0006259	biological_process	DNA metabolic process
A	0006265	biological_process	DNA topological change
B	0003677	molecular_function	DNA binding
B	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
B	0005524	molecular_function	ATP binding
B	0006265	biological_process	DNA topological change
C	0003677	molecular_function	DNA binding
C	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
C	0005524	molecular_function	ATP binding
C	0006259	biological_process	DNA metabolic process
C	0006265	biological_process	DNA topological change
D	0003677	molecular_function	DNA binding
D	0003918	molecular_function	DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
D	0005524	molecular_function	ATP binding
D	0006265	biological_process	DNA topological change

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG B 701

Chain	Residue
B	ASP532
B	ASP534
B	HOH804
B	HOH807
B	HOH809
B	HOH811

---

site_id	AC2
Number of Residues	6
Details	binding site for residue MG D 701

Chain	Residue
D	HOH803
D	HOH807
D	HOH811
D	ASP532
D	ASP534
D	HOH801

---

site_id	AC3
Number of Residues	18
Details	binding site for residue 8MX E 101

Chain	Residue
A	ARG128
A	PTR129
C	ALA90
C	HOH607
D	ARG482
D	GLU501
E	DT14
E	DA15
E	HOH203
E	HOH205
F	DT10
F	DA11
F	MG101
F	HOH205
G	DC14
G	DA15
H	DT10
H	DG11

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG E 102

Chain	Residue
H	8MX101
H	HOH201
H	HOH203
H	HOH204

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MG F 101

Chain	Residue
C	HOH607
E	8MX101
E	HOH205
F	HOH205

---

site_id	AC6
Number of Residues	17
Details	binding site for residue 8MX H 101

Chain	Residue
A	ALA90
B	ARG482
B	GLU501
C	ARG128
E	DT10
E	DG11
E	MG102
F	DC14
F	DA15
G	DT10
G	DA11
H	DT14
H	DA15
H	HOH201
H	HOH202
H	HOH203
H	HOH204

---

Functional Information from PROSITE/UniProt

site_id	PS00177
Number of Residues	9
Details	TOPOISOMERASE_II DNA topoisomerase II signature. VVEGDSAGG

Chain	Residue	Details
B	VAL457-GLY465

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"O-(5'-phospho-DNA)-tyrosine intermediate","evidences":[{"source":"HAMAP-Rule","id":"MF_01897","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	228
Details	Domain: {"description":"Toprim","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Interaction with DNA","evidences":[{"source":"HAMAP-Rule","id":"MF_01898","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---