Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BSE

Crystal structure of Medicago truncatula (delta)1-Pyrroline-5-Carboxylate Reductase (MtP5CR)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
A	0005737	cellular_component	cytoplasm
A	0008652	biological_process	amino acid biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0055129	biological_process	L-proline biosynthetic process
A	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
B	0000166	molecular_function	nucleotide binding
B	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
B	0005737	cellular_component	cytoplasm
B	0008652	biological_process	amino acid biosynthetic process
B	0016491	molecular_function	oxidoreductase activity
B	0055129	biological_process	L-proline biosynthetic process
B	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
C	0000166	molecular_function	nucleotide binding
C	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
C	0005737	cellular_component	cytoplasm
C	0008652	biological_process	amino acid biosynthetic process
C	0016491	molecular_function	oxidoreductase activity
C	0055129	biological_process	L-proline biosynthetic process
C	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
D	0000166	molecular_function	nucleotide binding
D	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
D	0005737	cellular_component	cytoplasm
D	0008652	biological_process	amino acid biosynthetic process
D	0016491	molecular_function	oxidoreductase activity
D	0055129	biological_process	L-proline biosynthetic process
D	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
E	0000166	molecular_function	nucleotide binding
E	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
E	0005737	cellular_component	cytoplasm
E	0008652	biological_process	amino acid biosynthetic process
E	0016491	molecular_function	oxidoreductase activity
E	0055129	biological_process	L-proline biosynthetic process
E	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
F	0000166	molecular_function	nucleotide binding
F	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
F	0005737	cellular_component	cytoplasm
F	0008652	biological_process	amino acid biosynthetic process
F	0016491	molecular_function	oxidoreductase activity
F	0055129	biological_process	L-proline biosynthetic process
F	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
G	0000166	molecular_function	nucleotide binding
G	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
G	0005737	cellular_component	cytoplasm
G	0008652	biological_process	amino acid biosynthetic process
G	0016491	molecular_function	oxidoreductase activity
G	0055129	biological_process	L-proline biosynthetic process
G	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
H	0000166	molecular_function	nucleotide binding
H	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
H	0005737	cellular_component	cytoplasm
H	0008652	biological_process	amino acid biosynthetic process
H	0016491	molecular_function	oxidoreductase activity
H	0055129	biological_process	L-proline biosynthetic process
H	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
I	0000166	molecular_function	nucleotide binding
I	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
I	0005737	cellular_component	cytoplasm
I	0008652	biological_process	amino acid biosynthetic process
I	0016491	molecular_function	oxidoreductase activity
I	0055129	biological_process	L-proline biosynthetic process
I	1902792	cellular_component	pyrroline-5-carboxylate reductase complex
J	0000166	molecular_function	nucleotide binding
J	0004735	molecular_function	pyrroline-5-carboxylate reductase activity
J	0005737	cellular_component	cytoplasm
J	0008652	biological_process	amino acid biosynthetic process
J	0016491	molecular_function	oxidoreductase activity
J	0055129	biological_process	L-proline biosynthetic process
J	1902792	cellular_component	pyrroline-5-carboxylate reductase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue MPO A 301

Chain	Residue
A	LYS80
B	THR243
B	CL301
A	PRO81
A	MET126
A	GLY180
A	SER181
A	HOH406
A	HOH537
B	SER238
B	THR242

site_id	AC2
Number of Residues	5
Details	binding site for residue CL A 302

Chain	Residue
A	VAL236
A	SER238
A	THR242
A	THR243
A	HOH422

site_id	AC3
Number of Residues	5
Details	binding site for residue CL B 301

Chain	Residue
A	MPO301
B	SER238
B	THR242
B	THR243
B	HOH440

site_id	AC4
Number of Residues	8
Details	binding site for residue MPO C 301

Chain	Residue
C	PRO81
C	ALA106
C	MET126
C	THR176
C	GLY180
D	SER238
D	THR242
D	CL301

site_id	AC5
Number of Residues	5
Details	binding site for residue CL C 302

Chain	Residue
C	SER238
C	THR242
C	THR243
C	HOH428
C	HOH455

site_id	AC6
Number of Residues	5
Details	binding site for residue CL D 301

Chain	Residue
C	MPO301
D	SER238
D	THR242
D	THR243
D	HOH413

site_id	AC7
Number of Residues	4
Details	binding site for residue CL E 301

Chain	Residue
E	SER238
E	THR242
E	THR243
E	HOH415

site_id	AC8
Number of Residues	4
Details	binding site for residue CL F 301

Chain	Residue
F	SER238
F	THR242
F	THR243
F	HOH423

site_id	AC9
Number of Residues	5
Details	binding site for residue CL G 301

Chain	Residue
G	SER238
G	THR242
G	THR243
G	HOH418
H	MPO301

site_id	AD1
Number of Residues	11
Details	binding site for residue MPO H 301

Chain	Residue
G	SER238
G	THR242
G	THR243
G	CL301
H	PRO81
H	ALA106
H	MET126
H	THR176
H	GLY180
H	SER181
H	HOH459

site_id	AD2
Number of Residues	5
Details	binding site for residue CL H 302

Chain	Residue
H	SER238
H	THR242
H	THR243
H	HOH463
H	HOH489

site_id	AD3
Number of Residues	11
Details	binding site for residue MPO I 301

Chain	Residue
I	PRO81
I	ALA106
I	MET126
I	GLY180
I	SER181
I	HOH404
I	HOH544
J	SER238
J	THR242
J	THR243
J	CL302

site_id	AD4
Number of Residues	6
Details	binding site for residue CL I 302

Chain	Residue
I	VAL236
I	SER238
I	THR242
I	THR243
I	HOH412
J	MPO301

site_id	AD5
Number of Residues	12
Details	binding site for residue MPO J 301

Chain	Residue
I	SER238
I	THR242
I	THR243
I	CL302
I	HOH444
J	PRO81
J	GLN82
J	ALA106
J	MET126
J	THR176
J	GLY180
J	SER181

site_id	AD6
Number of Residues	5
Details	binding site for residue CL J 302

Chain	Residue
J	THR242
J	THR243
J	HOH413
I	MPO301
J	SER238

Functional Information from PROSITE/UniProt

site_id	PS00521
Number of Residues	23
Details	P5CR Delta 1-pyrroline-5-carboxylate reductase signature. Pgq.LkddVTSpGGtTiaGVheLE

Chain	Residue	Details
A	PRO229-GLU251

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)