Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5BQJ

Structure of the yeast F1FO ATPase C10 ring with 21-hydroxy-oligomycin

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0008289	molecular_function	lipid binding
A	0015078	molecular_function	proton transmembrane transporter activity
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0031966	cellular_component	mitochondrial membrane
A	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
A	0042802	molecular_function	identical protein binding
A	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0008289	molecular_function	lipid binding
B	0015078	molecular_function	proton transmembrane transporter activity
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016020	cellular_component	membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0031966	cellular_component	mitochondrial membrane
B	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
B	0042802	molecular_function	identical protein binding
B	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
C	0005758	cellular_component	mitochondrial intermembrane space
C	0005829	cellular_component	cytosol
C	0008289	molecular_function	lipid binding
C	0015078	molecular_function	proton transmembrane transporter activity
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0031966	cellular_component	mitochondrial membrane
C	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
C	0042802	molecular_function	identical protein binding
C	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
D	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
D	0005739	cellular_component	mitochondrion
D	0005743	cellular_component	mitochondrial inner membrane
D	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005829	cellular_component	cytosol
D	0008289	molecular_function	lipid binding
D	0015078	molecular_function	proton transmembrane transporter activity
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016020	cellular_component	membrane
D	0016887	molecular_function	ATP hydrolysis activity
D	0031966	cellular_component	mitochondrial membrane
D	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
D	0042802	molecular_function	identical protein binding
D	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
E	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
E	0005739	cellular_component	mitochondrion
E	0005743	cellular_component	mitochondrial inner membrane
E	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005829	cellular_component	cytosol
E	0008289	molecular_function	lipid binding
E	0015078	molecular_function	proton transmembrane transporter activity
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016887	molecular_function	ATP hydrolysis activity
E	0031966	cellular_component	mitochondrial membrane
E	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
E	0042802	molecular_function	identical protein binding
E	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
K	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
K	0005739	cellular_component	mitochondrion
K	0005743	cellular_component	mitochondrial inner membrane
K	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
K	0005758	cellular_component	mitochondrial intermembrane space
K	0005829	cellular_component	cytosol
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0016887	molecular_function	ATP hydrolysis activity
K	0031966	cellular_component	mitochondrial membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0042802	molecular_function	identical protein binding
K	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
K	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
K	1902600	biological_process	proton transmembrane transport
L	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
L	0005758	cellular_component	mitochondrial intermembrane space
L	0005829	cellular_component	cytosol
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0016887	molecular_function	ATP hydrolysis activity
L	0031966	cellular_component	mitochondrial membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0042802	molecular_function	identical protein binding
L	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
L	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
L	1902600	biological_process	proton transmembrane transport
M	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
M	0005758	cellular_component	mitochondrial intermembrane space
M	0005829	cellular_component	cytosol
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0016887	molecular_function	ATP hydrolysis activity
M	0031966	cellular_component	mitochondrial membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0042802	molecular_function	identical protein binding
M	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
M	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
M	1902600	biological_process	proton transmembrane transport
N	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
N	0005758	cellular_component	mitochondrial intermembrane space
N	0005829	cellular_component	cytosol
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0016887	molecular_function	ATP hydrolysis activity
N	0031966	cellular_component	mitochondrial membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0042802	molecular_function	identical protein binding
N	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
N	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
N	1902600	biological_process	proton transmembrane transport
O	0000276	cellular_component	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)
O	0005739	cellular_component	mitochondrion
O	0005743	cellular_component	mitochondrial inner membrane
O	0005753	cellular_component	mitochondrial proton-transporting ATP synthase complex
O	0005758	cellular_component	mitochondrial intermembrane space
O	0005829	cellular_component	cytosol
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0016887	molecular_function	ATP hydrolysis activity
O	0031966	cellular_component	mitochondrial membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0042802	molecular_function	identical protein binding
O	0045263	cellular_component	proton-transporting ATP synthase complex, coupling factor F(o)
O	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
O	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue E21 B 101

Chain	Residue
B	ALA56
B	LEU57
B	ALA60
B	PHE64
B	E21102
C	ALA56
C	LEU63

site_id	AC2
Number of Residues	13
Details	binding site for residue E21 B 102

Chain	Residue
A	ALA60
A	PHE64
B	ILE52
B	PHE55
B	ALA56
B	GLU59
B	LEU63
B	E21101
B	HOH204
K	E21101
O	E21101
A	ALA56
A	LEU57

site_id	AC3
Number of Residues	7
Details	binding site for residue E21 E 101

Chain	Residue
D	ALA56
D	ALA60
E	PHE55
E	ALA56
E	GLU59
E	ALA60
E	LEU63

site_id	AC4
Number of Residues	17
Details	binding site for residue E21 K 101

Chain	Residue
A	ILE52
A	PHE55
A	ALA56
B	E21102
E	LEU53
E	LEU57
K	ILE52
K	ALA56
K	GLU59
K	ALA60
K	GLY62
K	LEU63
K	HOH209
L	E21101
O	ALA56
O	ALA60
O	PHE64

site_id	AC5
Number of Residues	9
Details	binding site for residue E21 L 101

Chain	Residue
K	ALA56
K	LEU57
K	ALA60
K	PHE64
K	E21101
L	ALA56
L	GLU59
L	LEU63
M	E21101

site_id	AC6
Number of Residues	10
Details	binding site for residue E21 M 101

Chain	Residue
C	LEU53
D	PHE55
L	ALA56
L	ALA60
L	PHE64
L	E21101
M	PHE55
M	ALA56
M	GLU59
M	LEU63

site_id	AC7
Number of Residues	8
Details	binding site for residue E21 O 101

Chain	Residue
B	E21102
B	HOH204
N	ALA56
N	ALA60
O	PHE55
O	ALA56
O	GLU59
O	LEU63

Functional Information from PROSITE/UniProt

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. SRNPsikdtVfPmaILgfaLsE

Chain	Residue	Details
A	SER38-GLU59

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	400
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
A	ILE14-ILE34
E	ILE52-LEU72
K	ILE14-ILE34
K	ILE52-LEU72
L	ILE14-ILE34
L	ILE52-LEU72
M	ILE14-ILE34
M	ILE52-LEU72
N	ILE14-ILE34
N	ILE52-LEU72
O	ILE14-ILE34
A	ILE52-LEU72
O	ILE52-LEU72
B	ILE14-ILE34
B	ILE52-LEU72
C	ILE14-ILE34
C	ILE52-LEU72
D	ILE14-ILE34
D	ILE52-LEU72
E	ILE14-ILE34

site_id	SWS_FT_FI2
Number of Residues	10
Details	SITE: Reversibly protonated during proton transport => ECO:0000250

Chain	Residue	Details
A	GLU59
O	GLU59
B	GLU59
C	GLU59
D	GLU59
E	GLU59
K	GLU59
L	GLU59
M	GLU59
N	GLU59

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N-formylmethionine => ECO:0000269\|PubMed:2894987

Chain	Residue	Details
A	FME1
O	FME1
B	FME1
C	FME1
D	FME1
E	FME1
K	FME1
L	FME1
M	FME1
N	FME1

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)