5BON

Crystal structure of human Nudt15 (MTH2)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000278	biological_process	mitotic cell cycle
A	0005515	molecular_function	protein binding
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006195	biological_process	purine nucleotide catabolic process
A	0006203	biological_process	dGTP catabolic process
A	0006950	biological_process	response to stress
A	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
A	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
A	0042178	biological_process	xenobiotic catabolic process
A	0042262	biological_process	DNA protection
A	0044715	molecular_function	8-oxo-dGDP phosphatase activity
A	0046872	molecular_function	metal ion binding
A	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
A	0055086	biological_process	nucleobase-containing small molecule metabolic process
A	0061136	biological_process	regulation of proteasomal protein catabolic process
A	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
A	1901292	biological_process	nucleoside phosphate catabolic process
B	0000278	biological_process	mitotic cell cycle
B	0005515	molecular_function	protein binding
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006195	biological_process	purine nucleotide catabolic process
B	0006203	biological_process	dGTP catabolic process
B	0006950	biological_process	response to stress
B	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
B	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
B	0042178	biological_process	xenobiotic catabolic process
B	0042262	biological_process	DNA protection
B	0044715	molecular_function	8-oxo-dGDP phosphatase activity
B	0046872	molecular_function	metal ion binding
B	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
B	0055086	biological_process	nucleobase-containing small molecule metabolic process
B	0061136	biological_process	regulation of proteasomal protein catabolic process
B	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
B	1901292	biological_process	nucleoside phosphate catabolic process
C	0000278	biological_process	mitotic cell cycle
C	0005515	molecular_function	protein binding
C	0005654	cellular_component	nucleoplasm
C	0005829	cellular_component	cytosol
C	0006195	biological_process	purine nucleotide catabolic process
C	0006203	biological_process	dGTP catabolic process
C	0006950	biological_process	response to stress
C	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
C	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
C	0016787	molecular_function	hydrolase activity
C	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
C	0042178	biological_process	xenobiotic catabolic process
C	0042262	biological_process	DNA protection
C	0044715	molecular_function	8-oxo-dGDP phosphatase activity
C	0046872	molecular_function	metal ion binding
C	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
C	0055086	biological_process	nucleobase-containing small molecule metabolic process
C	0061136	biological_process	regulation of proteasomal protein catabolic process
C	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
C	1901292	biological_process	nucleoside phosphate catabolic process
D	0000278	biological_process	mitotic cell cycle
D	0005515	molecular_function	protein binding
D	0005654	cellular_component	nucleoplasm
D	0005829	cellular_component	cytosol
D	0006195	biological_process	purine nucleotide catabolic process
D	0006203	biological_process	dGTP catabolic process
D	0006950	biological_process	response to stress
D	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
D	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
D	0016787	molecular_function	hydrolase activity
D	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
D	0042178	biological_process	xenobiotic catabolic process
D	0042262	biological_process	DNA protection
D	0044715	molecular_function	8-oxo-dGDP phosphatase activity
D	0046872	molecular_function	metal ion binding
D	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
D	0055086	biological_process	nucleobase-containing small molecule metabolic process
D	0061136	biological_process	regulation of proteasomal protein catabolic process
D	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
D	1901292	biological_process	nucleoside phosphate catabolic process
E	0000278	biological_process	mitotic cell cycle
E	0005515	molecular_function	protein binding
E	0005654	cellular_component	nucleoplasm
E	0005829	cellular_component	cytosol
E	0006195	biological_process	purine nucleotide catabolic process
E	0006203	biological_process	dGTP catabolic process
E	0006950	biological_process	response to stress
E	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
E	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
E	0016787	molecular_function	hydrolase activity
E	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
E	0042178	biological_process	xenobiotic catabolic process
E	0042262	biological_process	DNA protection
E	0044715	molecular_function	8-oxo-dGDP phosphatase activity
E	0046872	molecular_function	metal ion binding
E	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
E	0055086	biological_process	nucleobase-containing small molecule metabolic process
E	0061136	biological_process	regulation of proteasomal protein catabolic process
E	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
E	1901292	biological_process	nucleoside phosphate catabolic process
F	0000278	biological_process	mitotic cell cycle
F	0005515	molecular_function	protein binding
F	0005654	cellular_component	nucleoplasm
F	0005829	cellular_component	cytosol
F	0006195	biological_process	purine nucleotide catabolic process
F	0006203	biological_process	dGTP catabolic process
F	0006950	biological_process	response to stress
F	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
F	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
F	0016787	molecular_function	hydrolase activity
F	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
F	0042178	biological_process	xenobiotic catabolic process
F	0042262	biological_process	DNA protection
F	0044715	molecular_function	8-oxo-dGDP phosphatase activity
F	0046872	molecular_function	metal ion binding
F	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
F	0055086	biological_process	nucleobase-containing small molecule metabolic process
F	0061136	biological_process	regulation of proteasomal protein catabolic process
F	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
F	1901292	biological_process	nucleoside phosphate catabolic process
G	0000278	biological_process	mitotic cell cycle
G	0005515	molecular_function	protein binding
G	0005654	cellular_component	nucleoplasm
G	0005829	cellular_component	cytosol
G	0006195	biological_process	purine nucleotide catabolic process
G	0006203	biological_process	dGTP catabolic process
G	0006950	biological_process	response to stress
G	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
G	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
G	0016787	molecular_function	hydrolase activity
G	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
G	0042178	biological_process	xenobiotic catabolic process
G	0042262	biological_process	DNA protection
G	0044715	molecular_function	8-oxo-dGDP phosphatase activity
G	0046872	molecular_function	metal ion binding
G	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
G	0055086	biological_process	nucleobase-containing small molecule metabolic process
G	0061136	biological_process	regulation of proteasomal protein catabolic process
G	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
G	1901292	biological_process	nucleoside phosphate catabolic process
H	0000278	biological_process	mitotic cell cycle
H	0005515	molecular_function	protein binding
H	0005654	cellular_component	nucleoplasm
H	0005829	cellular_component	cytosol
H	0006195	biological_process	purine nucleotide catabolic process
H	0006203	biological_process	dGTP catabolic process
H	0006950	biological_process	response to stress
H	0008413	molecular_function	8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
H	0009217	biological_process	purine deoxyribonucleoside triphosphate catabolic process
H	0016787	molecular_function	hydrolase activity
H	0035539	molecular_function	8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
H	0042178	biological_process	xenobiotic catabolic process
H	0042262	biological_process	DNA protection
H	0044715	molecular_function	8-oxo-dGDP phosphatase activity
H	0046872	molecular_function	metal ion binding
H	0047429	molecular_function	nucleoside triphosphate diphosphatase activity
H	0055086	biological_process	nucleobase-containing small molecule metabolic process
H	0061136	biological_process	regulation of proteasomal protein catabolic process
H	0106405	molecular_function	isoprenoid diphosphate phosphatase activity
H	1901292	biological_process	nucleoside phosphate catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue MG A 201

Chain	Residue
A	GLU63
A	MG204
A	HOH323
A	HOH335
A	HOH383
A	HOH403
B	HOH412

---

site_id	AC2
Number of Residues	8
Details	binding site for residue MG A 202

Chain	Residue
A	MG203
A	MG204
A	HOH337
A	HOH344
A	HOH400
A	HOH413
A	GLY47
A	GLU67

---

site_id	AC3
Number of Residues	8
Details	binding site for residue MG A 203

Chain	Residue
A	GLU63
A	GLU67
A	MG202
A	MG204
A	HOH330
A	HOH333
A	HOH337
A	HOH403

---

site_id	AC4
Number of Residues	8
Details	binding site for residue MG A 204

Chain	Residue
A	MG201
A	MG202
A	MG203
A	HOH323
A	HOH337
A	HOH403
A	HOH423
A	HOH444

---

site_id	AC5
Number of Residues	8
Details	binding site for residue MG B 201

Chain	Residue
B	GLU63
B	GLU67
B	MG203
B	MG204
B	HOH318
B	HOH354
B	HOH375
B	HOH380

---

site_id	AC6
Number of Residues	7
Details	binding site for residue MG B 202

Chain	Residue
A	HOH422
B	GLU63
B	MG203
B	HOH316
B	HOH323
B	HOH325
B	HOH380

---

site_id	AC7
Number of Residues	9
Details	binding site for residue MG B 203

Chain	Residue
B	GLY48
B	GLU63
B	MG201
B	MG202
B	HOH316
B	HOH318
B	HOH380
B	HOH408
B	HOH420

---

site_id	AC8
Number of Residues	7
Details	binding site for residue MG B 204

Chain	Residue
B	GLY47
B	GLU67
B	MG201
B	HOH318
B	HOH330
B	HOH374
B	HOH403

---

site_id	AC9
Number of Residues	8
Details	binding site for residue MG C 201

Chain	Residue
C	GLY47
C	GLU67
C	MG203
C	MG204
C	HOH340
C	HOH383
C	HOH417
C	HOH419

---

site_id	AD1
Number of Residues	8
Details	binding site for residue MG C 202

Chain	Residue
C	GLU63
C	MG203
C	MG204
C	HOH343
C	HOH353
C	HOH365
C	HOH413
D	HOH388

---

site_id	AD2
Number of Residues	9
Details	binding site for residue MG C 203

Chain	Residue
C	GLU63
C	GLU67
C	MG201
C	MG202
C	MG204
C	HOH346
C	HOH361
C	HOH383
C	HOH413

---

site_id	AD3
Number of Residues	8
Details	binding site for residue MG C 204

Chain	Residue
C	MG201
C	MG202
C	MG203
C	HOH353
C	HOH383
C	HOH413
C	HOH423
D	HOH391

---

site_id	AD4
Number of Residues	8
Details	binding site for residue MG D 201

Chain	Residue
D	HOH308
D	HOH315
D	HOH357
D	HOH377
D	GLY47
D	GLU67
D	MG202
D	MG204

---

site_id	AD5
Number of Residues	9
Details	binding site for residue MG D 202

Chain	Residue
D	GLU63
D	GLU67
D	MG201
D	MG203
D	MG204
D	HOH308
D	HOH328
D	HOH347
D	HOH371

---

site_id	AD6
Number of Residues	8
Details	binding site for residue MG D 203

Chain	Residue
C	HOH424
D	GLU63
D	MG202
D	MG204
D	HOH316
D	HOH320
D	HOH349
D	HOH371

---

site_id	AD7
Number of Residues	10
Details	binding site for residue MG D 204

Chain	Residue
D	GLY48
D	GLU63
D	MG201
D	MG202
D	MG203
D	HOH308
D	HOH349
D	HOH371
D	HOH386
D	HOH398

---

site_id	AD8
Number of Residues	8
Details	binding site for residue MG E 201

Chain	Residue
E	GLY47
E	GLU67
E	MG202
E	MG203
E	HOH309
E	HOH322
E	HOH389
E	HOH395

---

site_id	AD9
Number of Residues	9
Details	binding site for residue MG E 202

Chain	Residue
E	GLY47
E	GLU63
E	GLU67
E	MG201
E	MG203
E	HOH309
E	HOH361
E	HOH365
E	HOH369

---

site_id	AE1
Number of Residues	10
Details	binding site for residue MG E 203

Chain	Residue
E	GLY48
E	GLU63
E	MG201
E	MG202
E	MG204
E	HOH309
E	HOH368
E	HOH369
E	HOH403
E	HOH417

---

site_id	AE2
Number of Residues	7
Details	binding site for residue MG E 204

Chain	Residue
E	GLU63
E	MG203
E	HOH327
E	HOH342
E	HOH368
E	HOH369
F	HOH436

---

site_id	AE3
Number of Residues	9
Details	binding site for residue MG F 201

Chain	Residue
F	GLU63
F	GLU67
F	MG202
F	MG203
F	MG204
F	HOH331
F	HOH344
F	HOH358
F	HOH413

---

site_id	AE4
Number of Residues	8
Details	binding site for residue MG F 202

Chain	Residue
E	HOH409
F	GLU63
F	MG201
F	MG204
F	HOH318
F	HOH342
F	HOH380
F	HOH413

---

site_id	AE5
Number of Residues	8
Details	binding site for residue MG F 203

Chain	Residue
F	GLY47
F	GLU67
F	MG201
F	MG204
F	HOH333
F	HOH358
F	HOH422
F	HOH432

---

site_id	AE6
Number of Residues	9
Details	binding site for residue MG F 204

Chain	Residue
F	GLY48
F	MG201
F	MG202
F	MG203
F	HOH318
F	HOH358
F	HOH413
F	HOH434
F	HOH452

---

site_id	AE7
Number of Residues	9
Details	binding site for residue MG G 201

Chain	Residue
G	GLY47
G	GLU63
G	GLU67
G	MG203
G	MG204
G	HOH313
G	HOH328
G	HOH355
G	HOH376

---

site_id	AE8
Number of Residues	7
Details	binding site for residue MG G 202

Chain	Residue
G	GLU63
G	MG203
G	HOH322
G	HOH324
G	HOH356
G	HOH376
H	HOH421

---

site_id	AE9
Number of Residues	9
Details	binding site for residue MG G 203

Chain	Residue
G	GLY48
G	GLU63
G	MG201
G	MG202
G	MG204
G	HOH313
G	HOH356
G	HOH376
G	HOH395

---

site_id	AF1
Number of Residues	8
Details	binding site for residue MG G 204

Chain	Residue
G	GLY47
G	GLU67
G	MG201
G	MG203
G	HOH313
G	HOH318
G	HOH329
G	HOH381

---

site_id	AF2
Number of Residues	8
Details	binding site for residue MG H 201

Chain	Residue
G	HOH390
H	GLU63
H	MG202
H	MG204
H	HOH341
H	HOH347
H	HOH374
H	HOH412

---

site_id	AF3
Number of Residues	9
Details	binding site for residue MG H 202

Chain	Residue
H	GLU63
H	GLU67
H	MG201
H	MG203
H	MG204
H	HOH329
H	HOH337
H	HOH346
H	HOH412

---

site_id	AF4
Number of Residues	8
Details	binding site for residue MG H 203

Chain	Residue
H	GLY47
H	GLU67
H	MG202
H	MG204
H	HOH329
H	HOH336
H	HOH401
H	HOH402

---

site_id	AF5
Number of Residues	7
Details	binding site for residue MG H 204

Chain	Residue
H	MG201
H	MG202
H	MG203
H	HOH329
H	HOH341
H	HOH412
H	HOH420

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	136
Details	Domain: {"description":"Nudix hydrolase","evidences":[{"source":"PROSITE-ProRule","id":"PRU00794","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	352
Details	Region: {"description":"Interaction with PCNA","evidences":[{"source":"PubMed","id":"19419956","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	168
Details	Motif: {"description":"Nudix box"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	16
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---