5BNW

The active site of O-GlcNAc transferase imposes constraints on substrate sequence

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006493	biological_process	protein O-linked glycosylation
A	0016757	molecular_function	glycosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	31
Details	binding site for residue 12V A 1101

Chain	Residue
A	HIS498
A	LYS842
A	LEU866
A	VAL895
A	ALA896
A	LYS898
A	HIS901
A	ARG904
A	CYS917
A	HIS920
A	THR921
A	PRO559
A	THR922
A	ASP925
A	HOH1205
A	HOH1222
A	HOH1227
A	HOH1240
A	HOH1271
D	SER186
D	ARG187
D	VAL188
A	THR560
D	THR189
D	HOH201
A	LEU563
A	LEU653
A	PRO656
A	PHE694
A	GLN839
A	TYR841

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P02545

Chain	Residue	Details
D	SER183

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site_id	SWS_FT_FI2
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) threonine => ECO:0000269|PubMed:26237509

Chain	Residue	Details
D	THR189
A	ASP968
A	LYS1022
A	ILE1027

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphothreonine; by AMPK => ECO:0000269|PubMed:24563466, ECO:0000269|PubMed:37541260

Chain	Residue	Details
A	MET570

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: O-linked (GlcNAc) serine; by autocatalysis => ECO:0000269|PubMed:27713473

Chain	Residue	Details
A	GLU515

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