5BMW

Crystal structure of T75V mutant of Triosephosphate isomerase from Plasmodium falciparum

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004807	molecular_function	triose-phosphate isomerase activity
A	0005829	cellular_component	cytosol
A	0006094	biological_process	gluconeogenesis
A	0006096	biological_process	glycolytic process
A	0016853	molecular_function	isomerase activity
A	0019563	biological_process	glycerol catabolic process
A	0042802	molecular_function	identical protein binding
A	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process
B	0004807	molecular_function	triose-phosphate isomerase activity
B	0005829	cellular_component	cytosol
B	0006094	biological_process	gluconeogenesis
B	0006096	biological_process	glycolytic process
B	0016853	molecular_function	isomerase activity
B	0019563	biological_process	glycerol catabolic process
B	0042802	molecular_function	identical protein binding
B	0046166	biological_process	glyceraldehyde-3-phosphate biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue EDO A 301

Chain	Residue
A	LYS100
A	LEU167
A	ILE170

---

site_id	AC2
Number of Residues	4
Details	binding site for residue EDO A 302

Chain	Residue
A	GLU107
A	ALA149
A	HOH519
A	HOH568

---

site_id	AC3
Number of Residues	6
Details	binding site for residue EDO A 303

Chain	Residue
A	GLN146
A	HOH451
A	HOH491
A	HOH590
A	GLY128
A	GLN133

---

site_id	AC4
Number of Residues	7
Details	binding site for residue EDO A 304

Chain	Residue
A	ASN10
A	LYS12
A	HIS95
A	LEU230
A	GLY232
A	HOH460
A	HOH477

---

site_id	AC5
Number of Residues	9
Details	binding site for residue EDO A 305

Chain	Residue
A	GLN222
A	SER246
A	MET248
A	CA309
A	HOH457
A	HOH511
B	GLU179
B	GLN223
B	HOH493

---

site_id	AC6
Number of Residues	5
Details	binding site for residue EDO A 306

Chain	Residue
A	ARG3
A	LYS4
A	TYR5
A	ASP227
A	HOH461

---

site_id	AC7
Number of Residues	5
Details	binding site for residue NA A 307

Chain	Residue
A	TYR5
A	ILE221
A	GLN223
A	ILE226
A	HOH461

---

site_id	AC8
Number of Residues	12
Details	binding site for residue MES A 308

Chain	Residue
A	SER19
A	SER22
A	LEU117
A	LYS118
A	ASN120
A	ASP155
A	ASN156
A	ASN159
A	GLU238
A	HOH478
A	HOH503
A	HOH555

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CA A 309

Chain	Residue
A	MET248
A	EDO305
A	HOH511
B	GLN223
B	HOH485
B	HOH493

---

site_id	AD1
Number of Residues	8
Details	binding site for residue EDO B 301

Chain	Residue
B	ASN10
B	LYS12
B	HIS95
B	LEU230
B	VAL231
B	GLY232
B	HOH419
B	HOH423

---

site_id	AD2
Number of Residues	6
Details	binding site for residue EDO B 302

Chain	Residue
A	GLY76
A	HOH411
B	ASN65
B	VAL78
B	HOH430
B	HOH566

---

site_id	AD3
Number of Residues	6
Details	binding site for residue NA B 303

Chain	Residue
B	TYR5
B	ILE221
B	GLN223
B	ILE226
B	HOH502
B	HOH525

---

Functional Information from PROSITE/UniProt

site_id	PS00171
Number of Residues	11
Details	TIM_1 Triosephosphate isomerase active site. VYEPLWAIGTG

Chain	Residue	Details
A	VAL163-GLY173

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Electrophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10127","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12403619","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12454456","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"14563846","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15465054","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19622869","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1LZO","evidenceCode":"ECO:0000312"},{"source":"PDB","id":"1LYX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M7P","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1O5X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1WOA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2VFI","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---