5B8D
Crystal structure of a low occupancy fragment candidate (N-(4-Methyl-1,3-thiazol-2-yl)propanamide) bound adjacent to the ubiquitin binding pocket of the HDAC6 zinc-finger domain
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0008270 | molecular_function | zinc ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1301 |
| Chain | Residue |
| A | CYS1145 |
| A | CYS1148 |
| A | HIS1164 |
| A | HIS1170 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1302 |
| Chain | Residue |
| A | CYS1133 |
| A | CYS1136 |
| A | CYS1153 |
| A | HIS1160 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 1303 |
| Chain | Residue |
| A | HIS1115 |
| A | CYS1183 |
| A | CYS1186 |
| A | CYS1113 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue FMT A 1304 |
| Chain | Residue |
| A | TRP1143 |
| A | GLY1154 |
| A | ARG1155 |
| A | LEU1162 |
| A | TYR1184 |
| A | HOH1409 |
| A | HOH1417 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue FMT A 1305 |
| Chain | Residue |
| A | TRP1143 |
| A | TRP1182 |
| A | TYR1189 |
| A | 6T41306 |
| A | HOH1445 |
| site_id | AC6 |
| Number of Residues | 8 |
| Details | binding site for residue 6T4 A 1306 |
| Chain | Residue |
| A | GLU1141 |
| A | ASN1142 |
| A | TRP1143 |
| A | SER1175 |
| A | ASP1178 |
| A | TYR1189 |
| A | ASN1200 |
| A | FMT1305 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue NA A 1343 |
| Chain | Residue |
| A | TYR1156 |
| A | ILE1157 |
| A | HOH1449 |
| A | HOH1469 |
| A | HOH1470 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 9 |
| Details | Region: {"description":"Ubiquitin binding","evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00502","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain.","authoringGroup":["Structural genomics consortium (SGC)"]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2009","submissionDatabase":"PDB data bank","title":"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG.","authoringGroup":["Structural genomics consortium (SGC)"]}}]} |
| Chain | Residue | Details |
