Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5B8A

Crystal structure of oxidized chimeric EcAhpC1-186-YFSKHN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006979	biological_process	response to oxidative stress
A	0008379	molecular_function	thioredoxin peroxidase activity
A	0009321	cellular_component	alkyl hydroperoxide reductase complex
A	0009970	biological_process	cellular response to sulfate starvation
A	0016020	cellular_component	membrane
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
A	0019290	biological_process	siderophore biosynthetic process
A	0032843	molecular_function	hydroperoxide reductase activity
A	0033194	biological_process	response to hydroperoxide
A	0033195	biological_process	response to alkyl hydroperoxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045454	biological_process	cell redox homeostasis
A	0051920	molecular_function	peroxiredoxin activity
A	0098869	biological_process	cellular oxidant detoxification
A	0102039	molecular_function	NADH-dependent peroxiredoxin activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006979	biological_process	response to oxidative stress
B	0008379	molecular_function	thioredoxin peroxidase activity
B	0009321	cellular_component	alkyl hydroperoxide reductase complex
B	0009970	biological_process	cellular response to sulfate starvation
B	0016020	cellular_component	membrane
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
B	0019290	biological_process	siderophore biosynthetic process
B	0032843	molecular_function	hydroperoxide reductase activity
B	0033194	biological_process	response to hydroperoxide
B	0033195	biological_process	response to alkyl hydroperoxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045454	biological_process	cell redox homeostasis
B	0051920	molecular_function	peroxiredoxin activity
B	0098869	biological_process	cellular oxidant detoxification
B	0102039	molecular_function	NADH-dependent peroxiredoxin activity
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006979	biological_process	response to oxidative stress
C	0008379	molecular_function	thioredoxin peroxidase activity
C	0009321	cellular_component	alkyl hydroperoxide reductase complex
C	0009970	biological_process	cellular response to sulfate starvation
C	0016020	cellular_component	membrane
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
C	0019290	biological_process	siderophore biosynthetic process
C	0032843	molecular_function	hydroperoxide reductase activity
C	0033194	biological_process	response to hydroperoxide
C	0033195	biological_process	response to alkyl hydroperoxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045454	biological_process	cell redox homeostasis
C	0051920	molecular_function	peroxiredoxin activity
C	0098869	biological_process	cellular oxidant detoxification
C	0102039	molecular_function	NADH-dependent peroxiredoxin activity
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006979	biological_process	response to oxidative stress
D	0008379	molecular_function	thioredoxin peroxidase activity
D	0009321	cellular_component	alkyl hydroperoxide reductase complex
D	0009970	biological_process	cellular response to sulfate starvation
D	0016020	cellular_component	membrane
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
D	0019290	biological_process	siderophore biosynthetic process
D	0032843	molecular_function	hydroperoxide reductase activity
D	0033194	biological_process	response to hydroperoxide
D	0033195	biological_process	response to alkyl hydroperoxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045454	biological_process	cell redox homeostasis
D	0051920	molecular_function	peroxiredoxin activity
D	0098869	biological_process	cellular oxidant detoxification
D	0102039	molecular_function	NADH-dependent peroxiredoxin activity
E	0004601	molecular_function	peroxidase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006979	biological_process	response to oxidative stress
E	0008379	molecular_function	thioredoxin peroxidase activity
E	0009321	cellular_component	alkyl hydroperoxide reductase complex
E	0009970	biological_process	cellular response to sulfate starvation
E	0016020	cellular_component	membrane
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
E	0019290	biological_process	siderophore biosynthetic process
E	0032843	molecular_function	hydroperoxide reductase activity
E	0033194	biological_process	response to hydroperoxide
E	0033195	biological_process	response to alkyl hydroperoxide
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045454	biological_process	cell redox homeostasis
E	0051920	molecular_function	peroxiredoxin activity
E	0098869	biological_process	cellular oxidant detoxification
E	0102039	molecular_function	NADH-dependent peroxiredoxin activity
F	0004601	molecular_function	peroxidase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006979	biological_process	response to oxidative stress
F	0008379	molecular_function	thioredoxin peroxidase activity
F	0009321	cellular_component	alkyl hydroperoxide reductase complex
F	0009970	biological_process	cellular response to sulfate starvation
F	0016020	cellular_component	membrane
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
F	0019290	biological_process	siderophore biosynthetic process
F	0032843	molecular_function	hydroperoxide reductase activity
F	0033194	biological_process	response to hydroperoxide
F	0033195	biological_process	response to alkyl hydroperoxide
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045454	biological_process	cell redox homeostasis
F	0051920	molecular_function	peroxiredoxin activity
F	0098869	biological_process	cellular oxidant detoxification
F	0102039	molecular_function	NADH-dependent peroxiredoxin activity
G	0004601	molecular_function	peroxidase activity
G	0005515	molecular_function	protein binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006979	biological_process	response to oxidative stress
G	0008379	molecular_function	thioredoxin peroxidase activity
G	0009321	cellular_component	alkyl hydroperoxide reductase complex
G	0009970	biological_process	cellular response to sulfate starvation
G	0016020	cellular_component	membrane
G	0016209	molecular_function	antioxidant activity
G	0016491	molecular_function	oxidoreductase activity
G	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
G	0019290	biological_process	siderophore biosynthetic process
G	0032843	molecular_function	hydroperoxide reductase activity
G	0033194	biological_process	response to hydroperoxide
G	0033195	biological_process	response to alkyl hydroperoxide
G	0042744	biological_process	hydrogen peroxide catabolic process
G	0042802	molecular_function	identical protein binding
G	0045454	biological_process	cell redox homeostasis
G	0051920	molecular_function	peroxiredoxin activity
G	0098869	biological_process	cellular oxidant detoxification
G	0102039	molecular_function	NADH-dependent peroxiredoxin activity
H	0004601	molecular_function	peroxidase activity
H	0005515	molecular_function	protein binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006979	biological_process	response to oxidative stress
H	0008379	molecular_function	thioredoxin peroxidase activity
H	0009321	cellular_component	alkyl hydroperoxide reductase complex
H	0009970	biological_process	cellular response to sulfate starvation
H	0016020	cellular_component	membrane
H	0016209	molecular_function	antioxidant activity
H	0016491	molecular_function	oxidoreductase activity
H	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
H	0019290	biological_process	siderophore biosynthetic process
H	0032843	molecular_function	hydroperoxide reductase activity
H	0033194	biological_process	response to hydroperoxide
H	0033195	biological_process	response to alkyl hydroperoxide
H	0042744	biological_process	hydrogen peroxide catabolic process
H	0042802	molecular_function	identical protein binding
H	0045454	biological_process	cell redox homeostasis
H	0051920	molecular_function	peroxiredoxin activity
H	0098869	biological_process	cellular oxidant detoxification
H	0102039	molecular_function	NADH-dependent peroxiredoxin activity
I	0004601	molecular_function	peroxidase activity
I	0005515	molecular_function	protein binding
I	0005737	cellular_component	cytoplasm
I	0005829	cellular_component	cytosol
I	0006979	biological_process	response to oxidative stress
I	0008379	molecular_function	thioredoxin peroxidase activity
I	0009321	cellular_component	alkyl hydroperoxide reductase complex
I	0009970	biological_process	cellular response to sulfate starvation
I	0016020	cellular_component	membrane
I	0016209	molecular_function	antioxidant activity
I	0016491	molecular_function	oxidoreductase activity
I	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
I	0019290	biological_process	siderophore biosynthetic process
I	0032843	molecular_function	hydroperoxide reductase activity
I	0033194	biological_process	response to hydroperoxide
I	0033195	biological_process	response to alkyl hydroperoxide
I	0042744	biological_process	hydrogen peroxide catabolic process
I	0042802	molecular_function	identical protein binding
I	0045454	biological_process	cell redox homeostasis
I	0051920	molecular_function	peroxiredoxin activity
I	0098869	biological_process	cellular oxidant detoxification
I	0102039	molecular_function	NADH-dependent peroxiredoxin activity
J	0004601	molecular_function	peroxidase activity
J	0005515	molecular_function	protein binding
J	0005737	cellular_component	cytoplasm
J	0005829	cellular_component	cytosol
J	0006979	biological_process	response to oxidative stress
J	0008379	molecular_function	thioredoxin peroxidase activity
J	0009321	cellular_component	alkyl hydroperoxide reductase complex
J	0009970	biological_process	cellular response to sulfate starvation
J	0016020	cellular_component	membrane
J	0016209	molecular_function	antioxidant activity
J	0016491	molecular_function	oxidoreductase activity
J	0016684	molecular_function	oxidoreductase activity, acting on peroxide as acceptor
J	0019290	biological_process	siderophore biosynthetic process
J	0032843	molecular_function	hydroperoxide reductase activity
J	0033194	biological_process	response to hydroperoxide
J	0033195	biological_process	response to alkyl hydroperoxide
J	0042744	biological_process	hydrogen peroxide catabolic process
J	0042802	molecular_function	identical protein binding
J	0045454	biological_process	cell redox homeostasis
J	0051920	molecular_function	peroxiredoxin activity
J	0098869	biological_process	cellular oxidant detoxification
J	0102039	molecular_function	NADH-dependent peroxiredoxin activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue SO4 A 201

Chain	Residue
A	PRO40
A	ARG112
A	ARG120
A	GLU139
A	HOH315
A	HOH322
A	HOH325

site_id	AC2
Number of Residues	5
Details	binding site for residue SO4 A 202

Chain	Residue
A	GLU87
A	THR88
A	HOH330
A	PRO48
A	SER86

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 203

Chain	Residue
A	GLY19
A	PHE21
A	LYS80
F	PHE45

site_id	AC4
Number of Residues	8
Details	binding site for residue GOL A 204

Chain	Residue
A	LYS7
A	GLU26
A	THR29
A	GLU30
A	PRO127
A	GLN128
A	GLY129
A	HOH304

site_id	AC5
Number of Residues	8
Details	binding site for residue GOL A 205

Chain	Residue
A	TYR39
A	ALA41
A	THR44
A	VAL46
A	CYS47
A	PRO48
A	LEU51
A	ARG120

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 B 201

Chain	Residue
B	TYR39
B	VAL46
B	CYS47
B	PRO48
B	GLU50
B	ARG120
B	HOH312

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 B 202

Chain	Residue
B	LYS17
B	TYR58
B	ASP67
B	VAL68
B	TYR69
B	TYR94
B	ALA95

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 B 203

Chain	Residue
B	PRO40
B	ARG112
B	ARG120
B	GLU139
B	GOL204

site_id	AC9
Number of Residues	5
Details	binding site for residue GOL B 204

Chain	Residue
B	ARG112
B	GLU115
B	LEU117
B	SO4203
C	PHE77

site_id	AD1
Number of Residues	3
Details	binding site for residue GOL B 205

Chain	Residue
B	PHE11
B	THR25
B	GLU26

site_id	AD2
Number of Residues	4
Details	binding site for residue SO4 C 201

Chain	Residue
B	PHE45
C	GLY19
C	PHE21
C	LYS80

site_id	AD3
Number of Residues	4
Details	binding site for residue SO4 D 201

Chain	Residue
D	GLU20
D	PHE21
D	LYS80
E	PHE45

site_id	AD4
Number of Residues	4
Details	binding site for residue SO4 D 202

Chain	Residue
D	SER86
D	GLU87
D	THR88
D	HOH315

site_id	AD5
Number of Residues	4
Details	binding site for residue GOL D 203

Chain	Residue
D	LYS17
D	TYR58
D	VAL68
D	TYR69

site_id	AD6
Number of Residues	2
Details	binding site for residue GOL D 204

Chain	Residue
D	CYS47
D	GLY140

site_id	AD7
Number of Residues	7
Details	binding site for residue GOL D 205

Chain	Residue
D	ALA41
D	THR44
D	VAL46
D	CYS47
D	PRO48
D	LEU51
D	ARG120

site_id	AD8
Number of Residues	5
Details	binding site for residue SO4 E 201

Chain	Residue
E	TYR39
E	CYS47
E	PRO48
E	GLU50
E	LEU51

site_id	AD9
Number of Residues	4
Details	binding site for residue SO4 E 202

Chain	Residue
E	SER86
E	THR88
E	GOL206
J	TRP170

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 E 203

Chain	Residue
E	PHE11
E	THR25
E	GLU26
E	LYS27

site_id	AE2
Number of Residues	3
Details	binding site for residue SO4 E 204

Chain	Residue
J	ASP144
E	ARG150
J	ASP53

site_id	AE3
Number of Residues	10
Details	binding site for residue GOL E 205

Chain	Residue
D	PRO100
D	THR101
D	ARG106
D	MET111
D	GLY116
D	HOH304
E	PRO100
E	THR101
E	ARG106
E	MET111

site_id	AE4
Number of Residues	4
Details	binding site for residue GOL E 206

Chain	Residue
E	THR44
E	PHE45
E	TRP82
E	SO4202

site_id	AE5
Number of Residues	3
Details	binding site for residue GOL E 207

Chain	Residue
E	SER2
J	PHE108
J	ASP109

site_id	AE6
Number of Residues	4
Details	binding site for residue SO4 F 201

Chain	Residue
F	PRO48
F	SER86
F	GLU87
F	THR88

site_id	AE7
Number of Residues	7
Details	binding site for residue SO4 F 202

Chain	Residue
F	TYR39
F	PRO40
F	CYS47
F	GLU50
F	LEU51
F	ARG120
F	HOH308

site_id	AE8
Number of Residues	2
Details	binding site for residue GOL F 203

Chain	Residue
F	GLY19
F	HOH312

site_id	AE9
Number of Residues	4
Details	binding site for residue SO4 G 201

Chain	Residue
G	PRO48
G	SER86
G	GLU87
G	THR88

site_id	AF1
Number of Residues	2
Details	binding site for residue SO4 G 202

Chain	Residue
G	THR6
G	LYS7

site_id	AF2
Number of Residues	3
Details	binding site for residue GOL G 203

Chain	Residue
G	GLN156
G	ALA159
G	SER160

site_id	AF3
Number of Residues	5
Details	binding site for residue GOL G 204

Chain	Residue
G	LYS7
G	GLU26
G	THR29
G	GLY129
G	HOH314

site_id	AF4
Number of Residues	8
Details	binding site for residue GOL G 205

Chain	Residue
G	TYR39
G	ALA41
G	THR44
G	VAL46
G	CYS47
G	GLU50
G	LEU51
G	ARG120

site_id	AF5
Number of Residues	4
Details	binding site for residue SO4 H 201

Chain	Residue
H	PRO48
H	SER86
H	GLU87
H	THR88

site_id	AF6
Number of Residues	6
Details	binding site for residue SO4 H 202

Chain	Residue
H	TYR39
H	CYS47
H	PRO48
H	GLU50
H	LEU51
H	ARG120

site_id	AF7
Number of Residues	4
Details	binding site for residue GOL H 203

Chain	Residue
H	ILE134
H	HOH302
I	SER2
I	LEU3

site_id	AF8
Number of Residues	4
Details	binding site for residue GOL H 204

Chain	Residue
H	ILE8
H	THR29
H	GLU30
H	GLY129

site_id	AF9
Number of Residues	6
Details	binding site for residue SO4 I 201

Chain	Residue
I	TYR39
I	CYS47
I	PRO48
I	GLU50
I	LEU51
I	ARG120

site_id	AG1
Number of Residues	4
Details	binding site for residue SO4 I 202

Chain	Residue
I	PHE21
I	LYS80
I	HOH309
J	PHE45

site_id	AG2
Number of Residues	4
Details	binding site for residue SO4 J 201

Chain	Residue
J	SER86
J	GLU87
J	THR88
J	GOL205

site_id	AG3
Number of Residues	6
Details	binding site for residue SO4 J 202

Chain	Residue
J	VAL46
J	CYS47
J	ARG120
J	GLY140
J	ILE141
J	GLY142

site_id	AG4
Number of Residues	8
Details	binding site for residue GOL J 203

Chain	Residue
J	THR44
J	VAL46
J	CYS47
J	PRO48
J	GLU50
J	LEU51
J	TRP82
J	ARG120

site_id	AG5
Number of Residues	4
Details	binding site for residue GOL J 204

Chain	Residue
I	ASP114
J	LYS12
J	GLN14
J	GLU23

site_id	AG6
Number of Residues	3
Details	binding site for residue GOL J 205

Chain	Residue
J	THR44
J	TRP82
J	SO4201

site_id	AG7
Number of Residues	3
Details	binding site for residue GOL J 206

Chain	Residue
J	SER84
J	SER85
J	GLU87

site_id	AG8
Number of Residues	6
Details	binding site for residue GOL J 207

Chain	Residue
I	PHE77
J	PRO40
J	VAL46
J	ARG112
J	LEU117
J	GLU139

site_id	AG9
Number of Residues	4
Details	binding site for residue GOL J 208

Chain	Residue
J	PHE11
J	LYS12
J	GLU26
J	LYS27

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	10
Details	ACT_SITE: Cysteine sulfenic acid (-SOH) intermediate => ECO:0000305\|PubMed:27892488

Chain	Residue	Details
A	CYS47
J	CYS47
B	CYS47
C	CYS47
D	CYS47
E	CYS47
F	CYS47
G	CYS47
H	CYS47
I	CYS47

site_id	SWS_FT_FI2
Number of Residues	50
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18723842

Chain	Residue	Details
A	LYS17
B	LYS171
C	LYS17
C	LYS93
C	LYS153
C	LYS169
C	LYS171
D	LYS17
D	LYS93
D	LYS153
D	LYS169
A	LYS93
D	LYS171
E	LYS17
E	LYS93
E	LYS153
E	LYS169
E	LYS171
F	LYS17
F	LYS93
F	LYS153
F	LYS169
A	LYS153
F	LYS171
G	LYS17
G	LYS93
G	LYS153
G	LYS169
G	LYS171
H	LYS17
H	LYS93
H	LYS153
H	LYS169
A	LYS169
H	LYS171
I	LYS17
I	LYS93
I	LYS153
I	LYS169
I	LYS171
J	LYS17
J	LYS93
J	LYS153
J	LYS169
A	LYS171
J	LYS171
B	LYS17
B	LYS93
B	LYS153
B	LYS169

site_id	SWS_FT_FI3
Number of Residues	10
Details	MOD_RES: N6-acetyllysine => ECO:0000269\|PubMed:18606987

Chain	Residue	Details
A	LYS190
J	LYS190
B	LYS190
C	LYS190
D	LYS190
E	LYS190
F	LYS190
G	LYS190
H	LYS190
I	LYS190

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)