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5B8A

Crystal structure of oxidized chimeric EcAhpC1-186-YFSKHN

Functional Information from GO Data
ChainGOidnamespacecontents
A0004601molecular_functionperoxidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006979biological_processresponse to oxidative stress
A0008379molecular_functionthioredoxin peroxidase activity
A0009321cellular_componentalkyl hydroperoxide reductase complex
A0009970biological_processcellular response to sulfate starvation
A0016020cellular_componentmembrane
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0019290biological_processsiderophore biosynthetic process
A0032843molecular_functionhydroperoxide reductase activity
A0033194biological_processresponse to hydroperoxide
A0033195biological_processresponse to alkyl hydroperoxide
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0045454biological_processcell redox homeostasis
A0051920molecular_functionperoxiredoxin activity
A0098869biological_processcellular oxidant detoxification
A0102039molecular_functionNADH-dependent peroxiredoxin activity
B0004601molecular_functionperoxidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006979biological_processresponse to oxidative stress
B0008379molecular_functionthioredoxin peroxidase activity
B0009321cellular_componentalkyl hydroperoxide reductase complex
B0009970biological_processcellular response to sulfate starvation
B0016020cellular_componentmembrane
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0019290biological_processsiderophore biosynthetic process
B0032843molecular_functionhydroperoxide reductase activity
B0033194biological_processresponse to hydroperoxide
B0033195biological_processresponse to alkyl hydroperoxide
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0045454biological_processcell redox homeostasis
B0051920molecular_functionperoxiredoxin activity
B0098869biological_processcellular oxidant detoxification
B0102039molecular_functionNADH-dependent peroxiredoxin activity
C0004601molecular_functionperoxidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006979biological_processresponse to oxidative stress
C0008379molecular_functionthioredoxin peroxidase activity
C0009321cellular_componentalkyl hydroperoxide reductase complex
C0009970biological_processcellular response to sulfate starvation
C0016020cellular_componentmembrane
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
C0019290biological_processsiderophore biosynthetic process
C0032843molecular_functionhydroperoxide reductase activity
C0033194biological_processresponse to hydroperoxide
C0033195biological_processresponse to alkyl hydroperoxide
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0045454biological_processcell redox homeostasis
C0051920molecular_functionperoxiredoxin activity
C0098869biological_processcellular oxidant detoxification
C0102039molecular_functionNADH-dependent peroxiredoxin activity
D0004601molecular_functionperoxidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006979biological_processresponse to oxidative stress
D0008379molecular_functionthioredoxin peroxidase activity
D0009321cellular_componentalkyl hydroperoxide reductase complex
D0009970biological_processcellular response to sulfate starvation
D0016020cellular_componentmembrane
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
D0019290biological_processsiderophore biosynthetic process
D0032843molecular_functionhydroperoxide reductase activity
D0033194biological_processresponse to hydroperoxide
D0033195biological_processresponse to alkyl hydroperoxide
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0045454biological_processcell redox homeostasis
D0051920molecular_functionperoxiredoxin activity
D0098869biological_processcellular oxidant detoxification
D0102039molecular_functionNADH-dependent peroxiredoxin activity
E0004601molecular_functionperoxidase activity
E0005515molecular_functionprotein binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0006979biological_processresponse to oxidative stress
E0008379molecular_functionthioredoxin peroxidase activity
E0009321cellular_componentalkyl hydroperoxide reductase complex
E0009970biological_processcellular response to sulfate starvation
E0016020cellular_componentmembrane
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
E0019290biological_processsiderophore biosynthetic process
E0032843molecular_functionhydroperoxide reductase activity
E0033194biological_processresponse to hydroperoxide
E0033195biological_processresponse to alkyl hydroperoxide
E0042744biological_processhydrogen peroxide catabolic process
E0042802molecular_functionidentical protein binding
E0045454biological_processcell redox homeostasis
E0051920molecular_functionperoxiredoxin activity
E0098869biological_processcellular oxidant detoxification
E0102039molecular_functionNADH-dependent peroxiredoxin activity
F0004601molecular_functionperoxidase activity
F0005515molecular_functionprotein binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0006979biological_processresponse to oxidative stress
F0008379molecular_functionthioredoxin peroxidase activity
F0009321cellular_componentalkyl hydroperoxide reductase complex
F0009970biological_processcellular response to sulfate starvation
F0016020cellular_componentmembrane
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
F0019290biological_processsiderophore biosynthetic process
F0032843molecular_functionhydroperoxide reductase activity
F0033194biological_processresponse to hydroperoxide
F0033195biological_processresponse to alkyl hydroperoxide
F0042744biological_processhydrogen peroxide catabolic process
F0042802molecular_functionidentical protein binding
F0045454biological_processcell redox homeostasis
F0051920molecular_functionperoxiredoxin activity
F0098869biological_processcellular oxidant detoxification
F0102039molecular_functionNADH-dependent peroxiredoxin activity
G0004601molecular_functionperoxidase activity
G0005515molecular_functionprotein binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0006979biological_processresponse to oxidative stress
G0008379molecular_functionthioredoxin peroxidase activity
G0009321cellular_componentalkyl hydroperoxide reductase complex
G0009970biological_processcellular response to sulfate starvation
G0016020cellular_componentmembrane
G0016209molecular_functionantioxidant activity
G0016491molecular_functionoxidoreductase activity
G0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
G0019290biological_processsiderophore biosynthetic process
G0032843molecular_functionhydroperoxide reductase activity
G0033194biological_processresponse to hydroperoxide
G0033195biological_processresponse to alkyl hydroperoxide
G0042744biological_processhydrogen peroxide catabolic process
G0042802molecular_functionidentical protein binding
G0045454biological_processcell redox homeostasis
G0051920molecular_functionperoxiredoxin activity
G0098869biological_processcellular oxidant detoxification
G0102039molecular_functionNADH-dependent peroxiredoxin activity
H0004601molecular_functionperoxidase activity
H0005515molecular_functionprotein binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0006979biological_processresponse to oxidative stress
H0008379molecular_functionthioredoxin peroxidase activity
H0009321cellular_componentalkyl hydroperoxide reductase complex
H0009970biological_processcellular response to sulfate starvation
H0016020cellular_componentmembrane
H0016209molecular_functionantioxidant activity
H0016491molecular_functionoxidoreductase activity
H0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
H0019290biological_processsiderophore biosynthetic process
H0032843molecular_functionhydroperoxide reductase activity
H0033194biological_processresponse to hydroperoxide
H0033195biological_processresponse to alkyl hydroperoxide
H0042744biological_processhydrogen peroxide catabolic process
H0042802molecular_functionidentical protein binding
H0045454biological_processcell redox homeostasis
H0051920molecular_functionperoxiredoxin activity
H0098869biological_processcellular oxidant detoxification
H0102039molecular_functionNADH-dependent peroxiredoxin activity
I0004601molecular_functionperoxidase activity
I0005515molecular_functionprotein binding
I0005737cellular_componentcytoplasm
I0005829cellular_componentcytosol
I0006979biological_processresponse to oxidative stress
I0008379molecular_functionthioredoxin peroxidase activity
I0009321cellular_componentalkyl hydroperoxide reductase complex
I0009970biological_processcellular response to sulfate starvation
I0016020cellular_componentmembrane
I0016209molecular_functionantioxidant activity
I0016491molecular_functionoxidoreductase activity
I0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
I0019290biological_processsiderophore biosynthetic process
I0032843molecular_functionhydroperoxide reductase activity
I0033194biological_processresponse to hydroperoxide
I0033195biological_processresponse to alkyl hydroperoxide
I0042744biological_processhydrogen peroxide catabolic process
I0042802molecular_functionidentical protein binding
I0045454biological_processcell redox homeostasis
I0051920molecular_functionperoxiredoxin activity
I0098869biological_processcellular oxidant detoxification
I0102039molecular_functionNADH-dependent peroxiredoxin activity
J0004601molecular_functionperoxidase activity
J0005515molecular_functionprotein binding
J0005737cellular_componentcytoplasm
J0005829cellular_componentcytosol
J0006979biological_processresponse to oxidative stress
J0008379molecular_functionthioredoxin peroxidase activity
J0009321cellular_componentalkyl hydroperoxide reductase complex
J0009970biological_processcellular response to sulfate starvation
J0016020cellular_componentmembrane
J0016209molecular_functionantioxidant activity
J0016491molecular_functionoxidoreductase activity
J0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
J0019290biological_processsiderophore biosynthetic process
J0032843molecular_functionhydroperoxide reductase activity
J0033194biological_processresponse to hydroperoxide
J0033195biological_processresponse to alkyl hydroperoxide
J0042744biological_processhydrogen peroxide catabolic process
J0042802molecular_functionidentical protein binding
J0045454biological_processcell redox homeostasis
J0051920molecular_functionperoxiredoxin activity
J0098869biological_processcellular oxidant detoxification
J0102039molecular_functionNADH-dependent peroxiredoxin activity
Functional Information from PDB Data
site_idAC1
Number of Residues7
Detailsbinding site for residue SO4 A 201
ChainResidue
APRO40
AARG112
AARG120
AGLU139
AHOH315
AHOH322
AHOH325

site_idAC2
Number of Residues5
Detailsbinding site for residue SO4 A 202
ChainResidue
AGLU87
ATHR88
AHOH330
APRO48
ASER86

site_idAC3
Number of Residues4
Detailsbinding site for residue SO4 A 203
ChainResidue
AGLY19
APHE21
ALYS80
FPHE45

site_idAC4
Number of Residues8
Detailsbinding site for residue GOL A 204
ChainResidue
ALYS7
AGLU26
ATHR29
AGLU30
APRO127
AGLN128
AGLY129
AHOH304

site_idAC5
Number of Residues8
Detailsbinding site for residue GOL A 205
ChainResidue
ATYR39
AALA41
ATHR44
AVAL46
ACYS47
APRO48
ALEU51
AARG120

site_idAC6
Number of Residues7
Detailsbinding site for residue SO4 B 201
ChainResidue
BTYR39
BVAL46
BCYS47
BPRO48
BGLU50
BARG120
BHOH312

site_idAC7
Number of Residues7
Detailsbinding site for residue SO4 B 202
ChainResidue
BLYS17
BTYR58
BASP67
BVAL68
BTYR69
BTYR94
BALA95

site_idAC8
Number of Residues5
Detailsbinding site for residue SO4 B 203
ChainResidue
BPRO40
BARG112
BARG120
BGLU139
BGOL204

site_idAC9
Number of Residues5
Detailsbinding site for residue GOL B 204
ChainResidue
BARG112
BGLU115
BLEU117
BSO4203
CPHE77

site_idAD1
Number of Residues3
Detailsbinding site for residue GOL B 205
ChainResidue
BPHE11
BTHR25
BGLU26

site_idAD2
Number of Residues4
Detailsbinding site for residue SO4 C 201
ChainResidue
BPHE45
CGLY19
CPHE21
CLYS80

site_idAD3
Number of Residues4
Detailsbinding site for residue SO4 D 201
ChainResidue
DGLU20
DPHE21
DLYS80
EPHE45

site_idAD4
Number of Residues4
Detailsbinding site for residue SO4 D 202
ChainResidue
DSER86
DGLU87
DTHR88
DHOH315

site_idAD5
Number of Residues4
Detailsbinding site for residue GOL D 203
ChainResidue
DLYS17
DTYR58
DVAL68
DTYR69

site_idAD6
Number of Residues2
Detailsbinding site for residue GOL D 204
ChainResidue
DCYS47
DGLY140

site_idAD7
Number of Residues7
Detailsbinding site for residue GOL D 205
ChainResidue
DALA41
DTHR44
DVAL46
DCYS47
DPRO48
DLEU51
DARG120

site_idAD8
Number of Residues5
Detailsbinding site for residue SO4 E 201
ChainResidue
ETYR39
ECYS47
EPRO48
EGLU50
ELEU51

site_idAD9
Number of Residues4
Detailsbinding site for residue SO4 E 202
ChainResidue
ESER86
ETHR88
EGOL206
JTRP170

site_idAE1
Number of Residues4
Detailsbinding site for residue SO4 E 203
ChainResidue
EPHE11
ETHR25
EGLU26
ELYS27

site_idAE2
Number of Residues3
Detailsbinding site for residue SO4 E 204
ChainResidue
JASP144
EARG150
JASP53

site_idAE3
Number of Residues10
Detailsbinding site for residue GOL E 205
ChainResidue
DPRO100
DTHR101
DARG106
DMET111
DGLY116
DHOH304
EPRO100
ETHR101
EARG106
EMET111

site_idAE4
Number of Residues4
Detailsbinding site for residue GOL E 206
ChainResidue
ETHR44
EPHE45
ETRP82
ESO4202

site_idAE5
Number of Residues3
Detailsbinding site for residue GOL E 207
ChainResidue
ESER2
JPHE108
JASP109

site_idAE6
Number of Residues4
Detailsbinding site for residue SO4 F 201
ChainResidue
FPRO48
FSER86
FGLU87
FTHR88

site_idAE7
Number of Residues7
Detailsbinding site for residue SO4 F 202
ChainResidue
FTYR39
FPRO40
FCYS47
FGLU50
FLEU51
FARG120
FHOH308

site_idAE8
Number of Residues2
Detailsbinding site for residue GOL F 203
ChainResidue
FGLY19
FHOH312

site_idAE9
Number of Residues4
Detailsbinding site for residue SO4 G 201
ChainResidue
GPRO48
GSER86
GGLU87
GTHR88

site_idAF1
Number of Residues2
Detailsbinding site for residue SO4 G 202
ChainResidue
GTHR6
GLYS7

site_idAF2
Number of Residues3
Detailsbinding site for residue GOL G 203
ChainResidue
GGLN156
GALA159
GSER160

site_idAF3
Number of Residues5
Detailsbinding site for residue GOL G 204
ChainResidue
GLYS7
GGLU26
GTHR29
GGLY129
GHOH314

site_idAF4
Number of Residues8
Detailsbinding site for residue GOL G 205
ChainResidue
GTYR39
GALA41
GTHR44
GVAL46
GCYS47
GGLU50
GLEU51
GARG120

site_idAF5
Number of Residues4
Detailsbinding site for residue SO4 H 201
ChainResidue
HPRO48
HSER86
HGLU87
HTHR88

site_idAF6
Number of Residues6
Detailsbinding site for residue SO4 H 202
ChainResidue
HTYR39
HCYS47
HPRO48
HGLU50
HLEU51
HARG120

site_idAF7
Number of Residues4
Detailsbinding site for residue GOL H 203
ChainResidue
HILE134
HHOH302
ISER2
ILEU3

site_idAF8
Number of Residues4
Detailsbinding site for residue GOL H 204
ChainResidue
HILE8
HTHR29
HGLU30
HGLY129

site_idAF9
Number of Residues6
Detailsbinding site for residue SO4 I 201
ChainResidue
ITYR39
ICYS47
IPRO48
IGLU50
ILEU51
IARG120

site_idAG1
Number of Residues4
Detailsbinding site for residue SO4 I 202
ChainResidue
IPHE21
ILYS80
IHOH309
JPHE45

site_idAG2
Number of Residues4
Detailsbinding site for residue SO4 J 201
ChainResidue
JSER86
JGLU87
JTHR88
JGOL205

site_idAG3
Number of Residues6
Detailsbinding site for residue SO4 J 202
ChainResidue
JVAL46
JCYS47
JARG120
JGLY140
JILE141
JGLY142

site_idAG4
Number of Residues8
Detailsbinding site for residue GOL J 203
ChainResidue
JTHR44
JVAL46
JCYS47
JPRO48
JGLU50
JLEU51
JTRP82
JARG120

site_idAG5
Number of Residues4
Detailsbinding site for residue GOL J 204
ChainResidue
IASP114
JLYS12
JGLN14
JGLU23

site_idAG6
Number of Residues3
Detailsbinding site for residue GOL J 205
ChainResidue
JTHR44
JTRP82
JSO4201

site_idAG7
Number of Residues3
Detailsbinding site for residue GOL J 206
ChainResidue
JSER84
JSER85
JGLU87

site_idAG8
Number of Residues6
Detailsbinding site for residue GOL J 207
ChainResidue
IPHE77
JPRO40
JVAL46
JARG112
JLEU117
JGLU139

site_idAG9
Number of Residues4
Detailsbinding site for residue GOL J 208
ChainResidue
JPHE11
JLYS12
JGLU26
JLYS27

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1550
DetailsDomain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues10
DetailsActive site: {"description":"Cysteine sulfenic acid (-SOH) intermediate","evidences":[{"source":"PubMed","id":"11904290","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues35
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"18723842","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues10
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues1
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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