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5B6M

Crystal structure of human peroxiredoxin 6 in reduced state

Functional Information from GO Data
ChainGOidnamespacecontents
A0003824molecular_functioncatalytic activity
A0004601molecular_functionperoxidase activity
A0004602molecular_functionglutathione peroxidase activity
A0004623molecular_functionphospholipase A2 activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0006629biological_processlipid metabolic process
A0006979biological_processresponse to oxidative stress
A0016020cellular_componentmembrane
A0016042biological_processlipid catabolic process
A0016209molecular_functionantioxidant activity
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016787molecular_functionhydrolase activity
A0031625molecular_functionubiquitin protein ligase binding
A0035578cellular_componentazurophil granule lumen
A0042744biological_processhydrogen peroxide catabolic process
A0042802molecular_functionidentical protein binding
A0045296molecular_functioncadherin binding
A0045454biological_processcell redox homeostasis
A0046475biological_processglycerophospholipid catabolic process
A0047184molecular_function1-acylglycerophosphocholine O-acyltransferase activity
A0047499molecular_functioncalcium-independent phospholipase A2 activity
A0048026biological_processpositive regulation of mRNA splicing, via spliceosome
A0048471cellular_componentperinuclear region of cytoplasm
A0051920molecular_functionperoxiredoxin activity
A0070062cellular_componentextracellular exosome
A0098869biological_processcellular oxidant detoxification
B0003824molecular_functioncatalytic activity
B0004601molecular_functionperoxidase activity
B0004602molecular_functionglutathione peroxidase activity
B0004623molecular_functionphospholipase A2 activity
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005829cellular_componentcytosol
B0006629biological_processlipid metabolic process
B0006979biological_processresponse to oxidative stress
B0016020cellular_componentmembrane
B0016042biological_processlipid catabolic process
B0016209molecular_functionantioxidant activity
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016787molecular_functionhydrolase activity
B0031625molecular_functionubiquitin protein ligase binding
B0035578cellular_componentazurophil granule lumen
B0042744biological_processhydrogen peroxide catabolic process
B0042802molecular_functionidentical protein binding
B0045296molecular_functioncadherin binding
B0045454biological_processcell redox homeostasis
B0046475biological_processglycerophospholipid catabolic process
B0047184molecular_function1-acylglycerophosphocholine O-acyltransferase activity
B0047499molecular_functioncalcium-independent phospholipase A2 activity
B0048026biological_processpositive regulation of mRNA splicing, via spliceosome
B0048471cellular_componentperinuclear region of cytoplasm
B0051920molecular_functionperoxiredoxin activity
B0070062cellular_componentextracellular exosome
B0098869biological_processcellular oxidant detoxification
C0003824molecular_functioncatalytic activity
C0004601molecular_functionperoxidase activity
C0004602molecular_functionglutathione peroxidase activity
C0004623molecular_functionphospholipase A2 activity
C0005515molecular_functionprotein binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005829cellular_componentcytosol
C0006629biological_processlipid metabolic process
C0006979biological_processresponse to oxidative stress
C0016020cellular_componentmembrane
C0016042biological_processlipid catabolic process
C0016209molecular_functionantioxidant activity
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0016787molecular_functionhydrolase activity
C0031625molecular_functionubiquitin protein ligase binding
C0035578cellular_componentazurophil granule lumen
C0042744biological_processhydrogen peroxide catabolic process
C0042802molecular_functionidentical protein binding
C0045296molecular_functioncadherin binding
C0045454biological_processcell redox homeostasis
C0046475biological_processglycerophospholipid catabolic process
C0047184molecular_function1-acylglycerophosphocholine O-acyltransferase activity
C0047499molecular_functioncalcium-independent phospholipase A2 activity
C0048026biological_processpositive regulation of mRNA splicing, via spliceosome
C0048471cellular_componentperinuclear region of cytoplasm
C0051920molecular_functionperoxiredoxin activity
C0070062cellular_componentextracellular exosome
C0098869biological_processcellular oxidant detoxification
D0003824molecular_functioncatalytic activity
D0004601molecular_functionperoxidase activity
D0004602molecular_functionglutathione peroxidase activity
D0004623molecular_functionphospholipase A2 activity
D0005515molecular_functionprotein binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005634cellular_componentnucleus
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005829cellular_componentcytosol
D0006629biological_processlipid metabolic process
D0006979biological_processresponse to oxidative stress
D0016020cellular_componentmembrane
D0016042biological_processlipid catabolic process
D0016209molecular_functionantioxidant activity
D0016491molecular_functionoxidoreductase activity
D0016740molecular_functiontransferase activity
D0016787molecular_functionhydrolase activity
D0031625molecular_functionubiquitin protein ligase binding
D0035578cellular_componentazurophil granule lumen
D0042744biological_processhydrogen peroxide catabolic process
D0042802molecular_functionidentical protein binding
D0045296molecular_functioncadherin binding
D0045454biological_processcell redox homeostasis
D0046475biological_processglycerophospholipid catabolic process
D0047184molecular_function1-acylglycerophosphocholine O-acyltransferase activity
D0047499molecular_functioncalcium-independent phospholipase A2 activity
D0048026biological_processpositive regulation of mRNA splicing, via spliceosome
D0048471cellular_componentperinuclear region of cytoplasm
D0051920molecular_functionperoxiredoxin activity
D0070062cellular_componentextracellular exosome
D0098869biological_processcellular oxidant detoxification
E0003824molecular_functioncatalytic activity
E0004601molecular_functionperoxidase activity
E0004602molecular_functionglutathione peroxidase activity
E0004623molecular_functionphospholipase A2 activity
E0005515molecular_functionprotein binding
E0005576cellular_componentextracellular region
E0005615cellular_componentextracellular space
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005764cellular_componentlysosome
E0005829cellular_componentcytosol
E0006629biological_processlipid metabolic process
E0006979biological_processresponse to oxidative stress
E0016020cellular_componentmembrane
E0016042biological_processlipid catabolic process
E0016209molecular_functionantioxidant activity
E0016491molecular_functionoxidoreductase activity
E0016740molecular_functiontransferase activity
E0016787molecular_functionhydrolase activity
E0031625molecular_functionubiquitin protein ligase binding
E0035578cellular_componentazurophil granule lumen
E0042744biological_processhydrogen peroxide catabolic process
E0042802molecular_functionidentical protein binding
E0045296molecular_functioncadherin binding
E0045454biological_processcell redox homeostasis
E0046475biological_processglycerophospholipid catabolic process
E0047184molecular_function1-acylglycerophosphocholine O-acyltransferase activity
E0047499molecular_functioncalcium-independent phospholipase A2 activity
E0048026biological_processpositive regulation of mRNA splicing, via spliceosome
E0048471cellular_componentperinuclear region of cytoplasm
E0051920molecular_functionperoxiredoxin activity
E0070062cellular_componentextracellular exosome
E0098869biological_processcellular oxidant detoxification
F0003824molecular_functioncatalytic activity
F0004601molecular_functionperoxidase activity
F0004602molecular_functionglutathione peroxidase activity
F0004623molecular_functionphospholipase A2 activity
F0005515molecular_functionprotein binding
F0005576cellular_componentextracellular region
F0005615cellular_componentextracellular space
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005764cellular_componentlysosome
F0005829cellular_componentcytosol
F0006629biological_processlipid metabolic process
F0006979biological_processresponse to oxidative stress
F0016020cellular_componentmembrane
F0016042biological_processlipid catabolic process
F0016209molecular_functionantioxidant activity
F0016491molecular_functionoxidoreductase activity
F0016740molecular_functiontransferase activity
F0016787molecular_functionhydrolase activity
F0031625molecular_functionubiquitin protein ligase binding
F0035578cellular_componentazurophil granule lumen
F0042744biological_processhydrogen peroxide catabolic process
F0042802molecular_functionidentical protein binding
F0045296molecular_functioncadherin binding
F0045454biological_processcell redox homeostasis
F0046475biological_processglycerophospholipid catabolic process
F0047184molecular_function1-acylglycerophosphocholine O-acyltransferase activity
F0047499molecular_functioncalcium-independent phospholipase A2 activity
F0048026biological_processpositive regulation of mRNA splicing, via spliceosome
F0048471cellular_componentperinuclear region of cytoplasm
F0051920molecular_functionperoxiredoxin activity
F0070062cellular_componentextracellular exosome
F0098869biological_processcellular oxidant detoxification
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues820
DetailsDomain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues45
DetailsRegion: {"description":"Required and sufficient for targeting to lysosomes and lamellar bodies","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues6
DetailsActive site: {"description":"Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity","evidences":[{"source":"PubMed","id":"10893423","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9497358","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9587003","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues6
DetailsActive site: {"description":"For phospholipase activity","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues6
DetailsSite: {"description":"Important for phospholipase activity","evidences":[{"source":"PubMed","id":"10893423","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI6
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI7
Number of Residues6
DetailsModified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI8
Number of Residues6
DetailsModified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI9
Number of Residues6
DetailsModified residue: {"description":"Phosphothreonine; by MAPK","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

site_idSWS_FT_FI10
Number of Residues6
DetailsModified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08709","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

243083

PDB entries from 2025-10-15

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