Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5B6M

Crystal structure of human peroxiredoxin 6 in reduced state

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004601	molecular_function	peroxidase activity
A	0004602	molecular_function	glutathione peroxidase activity
A	0004623	molecular_function	phospholipase A2 activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006979	biological_process	response to oxidative stress
A	0016020	cellular_component	membrane
A	0016042	biological_process	lipid catabolic process
A	0016209	molecular_function	antioxidant activity
A	0016491	molecular_function	oxidoreductase activity
A	0016740	molecular_function	transferase activity
A	0016787	molecular_function	hydrolase activity
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0035578	cellular_component	azurophil granule lumen
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0042802	molecular_function	identical protein binding
A	0045296	molecular_function	cadherin binding
A	0045454	biological_process	cell redox homeostasis
A	0046475	biological_process	glycerophospholipid catabolic process
A	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
A	0047499	molecular_function	calcium-independent phospholipase A2 activity
A	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051920	molecular_function	peroxiredoxin activity
A	0070062	cellular_component	extracellular exosome
A	0098869	biological_process	cellular oxidant detoxification
B	0003824	molecular_function	catalytic activity
B	0004601	molecular_function	peroxidase activity
B	0004602	molecular_function	glutathione peroxidase activity
B	0004623	molecular_function	phospholipase A2 activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006979	biological_process	response to oxidative stress
B	0016020	cellular_component	membrane
B	0016042	biological_process	lipid catabolic process
B	0016209	molecular_function	antioxidant activity
B	0016491	molecular_function	oxidoreductase activity
B	0016740	molecular_function	transferase activity
B	0016787	molecular_function	hydrolase activity
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0035578	cellular_component	azurophil granule lumen
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0042802	molecular_function	identical protein binding
B	0045296	molecular_function	cadherin binding
B	0045454	biological_process	cell redox homeostasis
B	0046475	biological_process	glycerophospholipid catabolic process
B	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
B	0047499	molecular_function	calcium-independent phospholipase A2 activity
B	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
B	0048471	cellular_component	perinuclear region of cytoplasm
B	0051920	molecular_function	peroxiredoxin activity
B	0070062	cellular_component	extracellular exosome
B	0098869	biological_process	cellular oxidant detoxification
C	0003824	molecular_function	catalytic activity
C	0004601	molecular_function	peroxidase activity
C	0004602	molecular_function	glutathione peroxidase activity
C	0004623	molecular_function	phospholipase A2 activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005764	cellular_component	lysosome
C	0005829	cellular_component	cytosol
C	0006629	biological_process	lipid metabolic process
C	0006979	biological_process	response to oxidative stress
C	0016020	cellular_component	membrane
C	0016042	biological_process	lipid catabolic process
C	0016209	molecular_function	antioxidant activity
C	0016491	molecular_function	oxidoreductase activity
C	0016740	molecular_function	transferase activity
C	0016787	molecular_function	hydrolase activity
C	0031625	molecular_function	ubiquitin protein ligase binding
C	0035578	cellular_component	azurophil granule lumen
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0042802	molecular_function	identical protein binding
C	0045296	molecular_function	cadherin binding
C	0045454	biological_process	cell redox homeostasis
C	0046475	biological_process	glycerophospholipid catabolic process
C	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
C	0047499	molecular_function	calcium-independent phospholipase A2 activity
C	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
C	0048471	cellular_component	perinuclear region of cytoplasm
C	0051920	molecular_function	peroxiredoxin activity
C	0070062	cellular_component	extracellular exosome
C	0098869	biological_process	cellular oxidant detoxification
D	0003824	molecular_function	catalytic activity
D	0004601	molecular_function	peroxidase activity
D	0004602	molecular_function	glutathione peroxidase activity
D	0004623	molecular_function	phospholipase A2 activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005764	cellular_component	lysosome
D	0005829	cellular_component	cytosol
D	0006629	biological_process	lipid metabolic process
D	0006979	biological_process	response to oxidative stress
D	0016020	cellular_component	membrane
D	0016042	biological_process	lipid catabolic process
D	0016209	molecular_function	antioxidant activity
D	0016491	molecular_function	oxidoreductase activity
D	0016740	molecular_function	transferase activity
D	0016787	molecular_function	hydrolase activity
D	0031625	molecular_function	ubiquitin protein ligase binding
D	0035578	cellular_component	azurophil granule lumen
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0042802	molecular_function	identical protein binding
D	0045296	molecular_function	cadherin binding
D	0045454	biological_process	cell redox homeostasis
D	0046475	biological_process	glycerophospholipid catabolic process
D	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
D	0047499	molecular_function	calcium-independent phospholipase A2 activity
D	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
D	0048471	cellular_component	perinuclear region of cytoplasm
D	0051920	molecular_function	peroxiredoxin activity
D	0070062	cellular_component	extracellular exosome
D	0098869	biological_process	cellular oxidant detoxification
E	0003824	molecular_function	catalytic activity
E	0004601	molecular_function	peroxidase activity
E	0004602	molecular_function	glutathione peroxidase activity
E	0004623	molecular_function	phospholipase A2 activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005764	cellular_component	lysosome
E	0005829	cellular_component	cytosol
E	0006629	biological_process	lipid metabolic process
E	0006979	biological_process	response to oxidative stress
E	0016020	cellular_component	membrane
E	0016042	biological_process	lipid catabolic process
E	0016209	molecular_function	antioxidant activity
E	0016491	molecular_function	oxidoreductase activity
E	0016740	molecular_function	transferase activity
E	0016787	molecular_function	hydrolase activity
E	0031625	molecular_function	ubiquitin protein ligase binding
E	0035578	cellular_component	azurophil granule lumen
E	0042744	biological_process	hydrogen peroxide catabolic process
E	0042802	molecular_function	identical protein binding
E	0045296	molecular_function	cadherin binding
E	0045454	biological_process	cell redox homeostasis
E	0046475	biological_process	glycerophospholipid catabolic process
E	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
E	0047499	molecular_function	calcium-independent phospholipase A2 activity
E	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
E	0048471	cellular_component	perinuclear region of cytoplasm
E	0051920	molecular_function	peroxiredoxin activity
E	0070062	cellular_component	extracellular exosome
E	0098869	biological_process	cellular oxidant detoxification
F	0003824	molecular_function	catalytic activity
F	0004601	molecular_function	peroxidase activity
F	0004602	molecular_function	glutathione peroxidase activity
F	0004623	molecular_function	phospholipase A2 activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005764	cellular_component	lysosome
F	0005829	cellular_component	cytosol
F	0006629	biological_process	lipid metabolic process
F	0006979	biological_process	response to oxidative stress
F	0016020	cellular_component	membrane
F	0016042	biological_process	lipid catabolic process
F	0016209	molecular_function	antioxidant activity
F	0016491	molecular_function	oxidoreductase activity
F	0016740	molecular_function	transferase activity
F	0016787	molecular_function	hydrolase activity
F	0031625	molecular_function	ubiquitin protein ligase binding
F	0035578	cellular_component	azurophil granule lumen
F	0042744	biological_process	hydrogen peroxide catabolic process
F	0042802	molecular_function	identical protein binding
F	0045296	molecular_function	cadherin binding
F	0045454	biological_process	cell redox homeostasis
F	0046475	biological_process	glycerophospholipid catabolic process
F	0047184	molecular_function	1-acylglycerophosphocholine O-acyltransferase activity
F	0047499	molecular_function	calcium-independent phospholipase A2 activity
F	0048026	biological_process	positive regulation of mRNA splicing, via spliceosome
F	0048471	cellular_component	perinuclear region of cytoplasm
F	0051920	molecular_function	peroxiredoxin activity
F	0070062	cellular_component	extracellular exosome
F	0098869	biological_process	cellular oxidant detoxification

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	820
Details	Domain: {"description":"Thioredoxin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00691","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	45
Details	Region: {"description":"Required and sufficient for targeting to lysosomes and lamellar bodies","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	6
Details	Active site: {"description":"Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity","evidences":[{"source":"PubMed","id":"10893423","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9497358","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9587003","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Active site: {"description":"For phospholipase activity","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	6
Details	Site: {"description":"Important for phospholipase activity","evidences":[{"source":"PubMed","id":"10893423","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	6
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	6
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Modified residue: {"description":"Phosphothreonine; by MAPK","evidences":[{"source":"UniProtKB","id":"O35244","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	6
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"O08709","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)