5B0B

Polyketide cyclase OAC from Cannabis sativa, I7F mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0009865	biological_process	pollen tube adhesion
A	0009975	molecular_function	cyclase activity
A	0016114	biological_process	terpenoid biosynthetic process
A	0016829	molecular_function	lyase activity
A	0046872	molecular_function	metal ion binding
A	1901696	biological_process	cannabinoid biosynthetic process
A	1901697	biological_process	olivetolic acid biosynthetic process
B	0005737	cellular_component	cytoplasm
B	0009865	biological_process	pollen tube adhesion
B	0009975	molecular_function	cyclase activity
B	0016114	biological_process	terpenoid biosynthetic process
B	0016829	molecular_function	lyase activity
B	0046872	molecular_function	metal ion binding
B	1901696	biological_process	cannabinoid biosynthetic process
B	1901697	biological_process	olivetolic acid biosynthetic process
C	0005737	cellular_component	cytoplasm
C	0009865	biological_process	pollen tube adhesion
C	0009975	molecular_function	cyclase activity
C	0016114	biological_process	terpenoid biosynthetic process
C	0016829	molecular_function	lyase activity
C	0046872	molecular_function	metal ion binding
C	1901696	biological_process	cannabinoid biosynthetic process
C	1901697	biological_process	olivetolic acid biosynthetic process
D	0005737	cellular_component	cytoplasm
D	0009865	biological_process	pollen tube adhesion
D	0009975	molecular_function	cyclase activity
D	0016114	biological_process	terpenoid biosynthetic process
D	0016829	molecular_function	lyase activity
D	0046872	molecular_function	metal ion binding
D	1901696	biological_process	cannabinoid biosynthetic process
D	1901697	biological_process	olivetolic acid biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 201

Chain	Residue
A	HIS5
A	PHE7
A	TYR72
A	HIS78
A	ILE94

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site_id	AC2
Number of Residues	3
Details	binding site for residue ACT B 201

Chain	Residue
B	HIS5
B	TYR72
B	HIS78

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site_id	AC3
Number of Residues	6
Details	binding site for residue ACT C 201

Chain	Residue
C	PHE7
C	TYR72
C	HIS78
C	ILE94
C	HOH318
C	HIS5

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT D 201

Chain	Residue
D	HIS5
D	PHE7
D	TYR72
D	HIS78

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Acid/base catalyst => ECO:0000269|PubMed:26783002

Chain	Residue	Details
A	TYR72
A	HIS75
B	TYR72
B	HIS75
C	TYR72
C	HIS75
D	TYR72
D	HIS75

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:26783002, ECO:0007744|PDB:5B09

Chain	Residue	Details
A	HIS5
A	TYR72
B	HIS5
B	TYR72
C	HIS5
C	TYR72
D	HIS5
D	TYR72

---

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	VAL31
D	VAL31
D	ILE34
D	MET37
A	ILE34
A	MET37
B	VAL31
B	ILE34
B	MET37
C	VAL31
C	ILE34
C	MET37

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