Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5AZF

Crystal structure of LGG-1 complexed with a WEEL peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000407	cellular_component	phagophore assembly site
A	0000421	cellular_component	autophagosome membrane
A	0000423	biological_process	mitophagy
A	0001778	biological_process	plasma membrane repair
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005776	cellular_component	autophagosome
A	0005886	cellular_component	plasma membrane
A	0006914	biological_process	autophagy
A	0006995	biological_process	cellular response to nitrogen starvation
A	0008340	biological_process	determination of adult lifespan
A	0008429	molecular_function	phosphatidylethanolamine binding
A	0009408	biological_process	response to heat
A	0012501	biological_process	programmed cell death
A	0016236	biological_process	macroautophagy
A	0030425	cellular_component	dendrite
A	0030670	cellular_component	phagocytic vesicle membrane
A	0031410	cellular_component	cytoplasmic vesicle
A	0031625	molecular_function	ubiquitin protein ligase binding
A	0040024	biological_process	dauer larval development
A	0043005	cellular_component	neuron projection
A	0043025	cellular_component	neuronal cell body
A	0043202	cellular_component	lysosomal lumen
A	0043204	cellular_component	perikaryon
A	0050811	molecular_function	GABA receptor binding
A	0050830	biological_process	defense response to Gram-positive bacterium
A	0070266	biological_process	necroptotic process
A	0097237	biological_process	cellular response to toxic substance
A	0097352	biological_process	autophagosome maturation
A	0098792	biological_process	xenophagy
A	2000786	biological_process	positive regulation of autophagosome assembly
B	0000045	biological_process	autophagosome assembly
B	0000407	cellular_component	phagophore assembly site
B	0000421	cellular_component	autophagosome membrane
B	0000423	biological_process	mitophagy
B	0001778	biological_process	plasma membrane repair
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005776	cellular_component	autophagosome
B	0005886	cellular_component	plasma membrane
B	0006914	biological_process	autophagy
B	0006995	biological_process	cellular response to nitrogen starvation
B	0008340	biological_process	determination of adult lifespan
B	0008429	molecular_function	phosphatidylethanolamine binding
B	0009408	biological_process	response to heat
B	0012501	biological_process	programmed cell death
B	0016236	biological_process	macroautophagy
B	0030425	cellular_component	dendrite
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031410	cellular_component	cytoplasmic vesicle
B	0031625	molecular_function	ubiquitin protein ligase binding
B	0040024	biological_process	dauer larval development
B	0043005	cellular_component	neuron projection
B	0043025	cellular_component	neuronal cell body
B	0043202	cellular_component	lysosomal lumen
B	0043204	cellular_component	perikaryon
B	0050811	molecular_function	GABA receptor binding
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0070266	biological_process	necroptotic process
B	0097237	biological_process	cellular response to toxic substance
B	0097352	biological_process	autophagosome maturation
B	0098792	biological_process	xenophagy
B	2000786	biological_process	positive regulation of autophagosome assembly

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CD A 201

Chain	Residue
A	HIS42
A	ASP97
A	HOH347
A	HOH426
A	HOH428
A	HOH435

site_id	AC2
Number of Residues	6
Details	binding site for residue CD A 202

Chain	Residue
A	HOH439
A	HOH451
A	HOH490
A	HIS98
A	HOH338
A	HOH432

site_id	AC3
Number of Residues	6
Details	binding site for residue CD A 203

Chain	Residue
A	HIS99
A	CD205
A	HOH374
A	HOH445
A	HOH461
A	HOH462

site_id	AC4
Number of Residues	5
Details	binding site for residue CD A 204

Chain	Residue
A	HIS0
A	GLY116
B	GLY-2
B	HOH394
B	HOH396

site_id	AC5
Number of Residues	4
Details	binding site for residue CD A 205

Chain	Residue
A	HIS99
A	CD203
A	HOH374
A	HOH434

site_id	AC6
Number of Residues	6
Details	binding site for residue CD B 201

Chain	Residue
B	HIS42
B	ASP97
B	HOH346
B	HOH429
B	HOH441
B	HOH445

site_id	AC7
Number of Residues	6
Details	binding site for residue CD B 202

Chain	Residue
B	HIS98
B	HOH319
B	HOH436
B	HOH452
B	HOH455
B	HOH482

site_id	AC8
Number of Residues	5
Details	binding site for residue CD B 203

Chain	Residue
B	HIS99
B	CD207
B	HOH369
B	HOH458
B	HOH467

site_id	AC9
Number of Residues	5
Details	binding site for residue CD B 204

Chain	Residue
A	GLY-2
A	HOH337
A	HOH388
B	HIS0
B	GLY116

site_id	AD1
Number of Residues	5
Details	binding site for residue CD B 205

Chain	Residue
B	ASP27
B	HOH410
B	HOH437
C	TRP1
C	HOH109

site_id	AD2
Number of Residues	1
Details	binding site for residue CD B 206

Chain	Residue
B	GLU17

site_id	AD3
Number of Residues	4
Details	binding site for residue CD B 207

Chain	Residue
B	HIS99
B	CD203
B	HOH369
B	HOH412

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 B 208

Chain	Residue
B	LYS46
B	LYS47
B	LYS48
B	HOH311
B	HOH326

site_id	AD5
Number of Residues	4
Details	binding site for residue CD D 101

Chain	Residue
D	TRP1
D	HOH201
D	HOH205
D	HOH209

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	Site: {"description":"Required for the interaction with unc-51","evidences":[{"source":"PubMed","id":"26687600","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Site: {"description":"Required for interaction with sqst-1","evidences":[{"source":"PubMed","id":"26687600","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	2
Details	Lipidation: {"description":"Phosphatidylethanolamine amidated glycine","evidences":[{"source":"PubMed","id":"22767594","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20550938","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"21802374","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	6
Details	Motif: {"description":"WXXL"}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)