5AYN
Crystal structure of a bacterial homologue of iron transporter ferroportin in outward-facing state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005381 | molecular_function | iron ion transmembrane transporter activity |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006826 | biological_process | iron ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034755 | biological_process | iron ion transmembrane transport |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055085 | biological_process | transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue K A 501 |
| Chain | Residue |
| A | THR20 |
| A | ASP24 |
| A | ASN196 |
| A | SER199 |
| A | PHE200 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 502 |
| Chain | Residue |
| A | TYR204 |
| A | ARG208 |
| A | TYR404 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 503 |
| Chain | Residue |
| A | LYS42 |
| A | LEU112 |
| A | SER113 |
| A | PHE116 |
| A | PHE39 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 504 |
| Chain | Residue |
| A | LEU305 |
| A | TRP313 |
| A | HIS314 |
| A | PHE317 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | binding site for residue OLC A 505 |
| Chain | Residue |
| A | SER309 |
| A | ARG312 |
| A | TRP313 |
| A | GLY316 |
| A | PHE317 |
| A | ILE324 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue OLC A 506 |
| Chain | Residue |
| A | PHE86 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 507 |
| Chain | Residue |
| A | PHE290 |
| A | CYS343 |
| A | OLC508 |
| site_id | AC8 |
| Number of Residues | 6 |
| Details | binding site for residue OLC A 508 |
| Chain | Residue |
| A | GLY215 |
| A | GLU279 |
| A | PHE283 |
| A | TYR338 |
| A | OLC507 |
| A | OLC509 |
| site_id | AC9 |
| Number of Residues | 6 |
| Details | binding site for residue OLC A 509 |
| Chain | Residue |
| A | GLY100 |
| A | ALA104 |
| A | LYS217 |
| A | LYS219 |
| A | OLC508 |
| A | HOH653 |
| site_id | AD1 |
| Number of Residues | 5 |
| Details | binding site for residue OLC A 510 |
| Chain | Residue |
| A | GLN12 |
| A | LEU206 |
| A | ASN209 |
| A | SER391 |
| A | SER394 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 43 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000305|PubMed:26461048 |
| Chain | Residue | Details |
| A | MET1-ARG8 | |
| A | THR70-PRO72 | |
| A | VAL146-ALA147 | |
| A | SER214-PRO242 | |
| A | LEU305-GLY306 | |
| A | ILE366-ARG370 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | ILE9-ILE38 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 28 |
| Details | TOPO_DOM: Extracellular => ECO:0000305|PubMed:26461048 |
| Chain | Residue | Details |
| A | PHE39-LYS42 | |
| A | ALA104-SER109 | |
| A | PHE177-LEU186 | |
| A | GLU272-PRO276 | |
| A | ALA330-ALA335 | |
| A | LEU396-GLN398 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | LEU43-ASP69 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 30 |
| Details | TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | ARG73-ARG103 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 35 |
| Details | TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | TRP110-LEU145 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | PRO148-LEU176 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 26 |
| Details | TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | ALA187-ARG213 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 28 |
| Details | TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | ILE243-ASP271 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 27 |
| Details | TRANSMEM: Helical; Name=8 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | GLU277-ARG304 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 22 |
| Details | TRANSMEM: Helical; Name=9 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | LEU307-PHE329 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 29 |
| Details | TRANSMEM: Helical; Name=10 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | SER336-LEU365 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 24 |
| Details | TRANSMEM: Helical; Name=11 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | ARG371-LEU395 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 25 |
| Details | TRANSMEM: Helical; Name=12 => ECO:0000269|PubMed:26461048, ECO:0007744|PDB:5AYN |
| Chain | Residue | Details |
| A | THR399-SER424 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:30082682, ECO:0007744|PDB:6BTX |
| Chain | Residue | Details |
| A | ASP24 | |
| A | GLN84 | |
| A | ASN196 | |
| A | GLU203 |
