Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5AVM

Crystal structures of 5-aminoimidazole ribonucleotide (AIR) synthetase, PurM, from Thermus thermophilus

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
A	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006189	biological_process	'de novo' IMP biosynthetic process
A	0016874	molecular_function	ligase activity
A	0046084	biological_process	adenine biosynthetic process
B	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
B	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006189	biological_process	'de novo' IMP biosynthetic process
B	0016874	molecular_function	ligase activity
B	0046084	biological_process	adenine biosynthetic process
C	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
C	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006189	biological_process	'de novo' IMP biosynthetic process
C	0016874	molecular_function	ligase activity
C	0046084	biological_process	adenine biosynthetic process
D	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
D	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006189	biological_process	'de novo' IMP biosynthetic process
D	0016874	molecular_function	ligase activity
D	0046084	biological_process	adenine biosynthetic process
E	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
E	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006189	biological_process	'de novo' IMP biosynthetic process
E	0016874	molecular_function	ligase activity
E	0046084	biological_process	adenine biosynthetic process
F	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
F	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006189	biological_process	'de novo' IMP biosynthetic process
F	0016874	molecular_function	ligase activity
F	0046084	biological_process	adenine biosynthetic process
G	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
G	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006189	biological_process	'de novo' IMP biosynthetic process
G	0016874	molecular_function	ligase activity
G	0046084	biological_process	adenine biosynthetic process
H	0004637	molecular_function	phosphoribosylamine-glycine ligase activity
H	0004641	molecular_function	phosphoribosylformylglycinamidine cyclo-ligase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006189	biological_process	'de novo' IMP biosynthetic process
H	0016874	molecular_function	ligase activity
H	0046084	biological_process	adenine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	binding site for residue SO4 A 401

Chain	Residue
A	THR65
A	THR187
A	ASN188
A	GLY189
A	TYR190
A	SER191
A	HOH531
A	HOH542
A	HOH552

site_id	AC2
Number of Residues	2
Details	binding site for residue SO4 A 402

Chain	Residue
A	ASP75
A	LEU218

site_id	AC3
Number of Residues	4
Details	binding site for residue SO4 A 403

Chain	Residue
A	SER191
A	ARG194
A	HOH516
B	GLY143

site_id	AC4
Number of Residues	7
Details	binding site for residue SO4 B 401

Chain	Residue
B	THR65
B	ASN188
B	GLY189
B	TYR190
B	SER191
B	HOH538
B	HOH592

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 B 402

Chain	Residue
B	ASP75
B	SER77
B	LEU218
B	HOH528
B	HOH582

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 C 401

Chain	Residue
C	THR65
C	GLY189
C	TYR190
C	SER191
C	HOH518
C	HOH593

site_id	AC7
Number of Residues	7
Details	binding site for residue SO4 C 402

Chain	Residue
C	SER191
C	ARG194
C	LYS195
C	HOH530
C	HOH643
D	PRO142
D	GLY143

site_id	AC8
Number of Residues	8
Details	binding site for residue SO4 D 401

Chain	Residue
D	GLY64
D	THR65
D	ASN188
D	GLY189
D	TYR190
D	SER191
D	HOH567
D	HOH627

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 D 402

Chain	Residue
D	ALA128
D	HIS129
D	LYS226
D	HOH535
D	HOH539
D	HOH581
D	HOH625

site_id	AD1
Number of Residues	9
Details	binding site for residue SO4 E 401

Chain	Residue
E	THR65
E	THR187
E	ASN188
E	GLY189
E	TYR190
E	SER191
E	HOH521
E	HOH533
E	HOH584

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 E 402

Chain	Residue
E	ARG162
E	ARG170
E	HOH563

site_id	AD3
Number of Residues	7
Details	binding site for residue SO4 F 401

Chain	Residue
F	THR65
F	GLY189
F	TYR190
F	SER191
F	HOH556
F	HOH581
F	HOH583

site_id	AD4
Number of Residues	5
Details	binding site for residue SO4 G 401

Chain	Residue
G	THR65
G	GLY189
G	TYR190
G	SER191
G	HOH505

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 G 402

Chain	Residue
G	LYS314
G	LEU315
G	VAL316
G	HOH551
G	HOH602
G	HOH612

site_id	AD6
Number of Residues	4
Details	binding site for residue SO4 G 403

Chain	Residue
G	ARG162
G	ARG170
G	HOH584
G	HOH589

site_id	AD7
Number of Residues	9
Details	binding site for residue SO4 H 401

Chain	Residue
H	GLY64
H	THR65
H	THR187
H	ASN188
H	GLY189
H	TYR190
H	SER191
H	HOH526
H	HOH541

site_id	AD8
Number of Residues	2
Details	binding site for residue SO4 H 402

Chain	Residue
H	HOH564
H	ARG219

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)