5APR

STRUCTURES OF COMPLEXES OF RHIZOPUSPEPSIN WITH PEPSTATIN AND OTHER STATINE-CONTAINING INHIBITORS

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA I 400

Chain	Residue
E	GLY220
E	HOH525
E	HOH718
I	PHE4
I	CYS5
I	STA6

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site_id	AC2
Number of Residues	21
Details	BINDING SITE FOR CHAIN I OF PEPSTATIN-LIKE RENIN INHIBITOR

Chain	Residue
E	GLU16
E	ASP35
E	GLY37
E	TYR77
E	GLY78
E	ASP79
E	SER81
E	TRP194
E	ASP218
E	GLY220
E	THR221
E	THR222
E	TRP294
E	ILE298
E	HOH507
E	HOH525
E	HOH560
E	HOH752
I	CA400
I	HOH671
E	ILE15

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site_id	CAT
Number of Residues	2
Details	CATALYTICALLY ACTIVE RESIDUES

Chain	Residue
E	ASP35
E	ASP218

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. LDFDTGSSDLWI

Chain	Residue	Details
E	LEU32-ILE43
E	GLY215-LEU226

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094

Chain	Residue	Details
E	ASP35
E	ASP218

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