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5AP5

Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004672molecular_functionprotein kinase activity
A0005524molecular_functionATP binding
A0006468biological_processprotein phosphorylation
Functional Information from PDB Data
site_idAC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE 7RO A 1795
ChainResidue
AILE531
AASP608
ALEU654
AILE663
A1KA1796
AHOH2002
AALA551
ALYS553
AILE586
AMET602
AGLU603
ACYS604
AGLY605
AASN606

site_idAC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE 1KA A 1796
ChainResidue
ALYS553
AVAL555
ATYR568
AGLU571
A7RO1795

site_idAC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PGE A 1797
ChainResidue
ATRP622
ASER626
ALYS629
AVAL791
AILE793

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE EDO A 1798
ChainResidue
AASP595
AHIS636
AHIS639
AILE782
APRO783

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE EDO A 1799
ChainResidue
ATRP622
ASER626
AGLY658

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues23
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGSGGSSKVFqVlnekkqi...........YAIK
ChainResidueDetails
AILE531-LYS553

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IvHsDLKpaNFLI
ChainResidueDetails
AILE643-ILE655

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10027","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues9
DetailsBinding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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