Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5AOV

Ternary Crystal Structure of Pyrococcus furiosus Glyoxylate Hydroxypyruvate Reductase in presence of glyoxylate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0016618	molecular_function	hydroxypyruvate reductase [NAD(P)H] activity
A	0030267	molecular_function	glyoxylate reductase (NADPH) activity
A	0047964	molecular_function	glyoxylate reductase (NADH) activity
A	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	41
Details	BINDING SITE FOR RESIDUE NAP A 1335

Chain	Residue
A	ARG32
A	TYR179
A	SER180
A	ARG181
A	THR182
A	LYS184
A	ALA211
A	VAL212
A	PRO213
A	GLU217
A	THR218
A	LYS42
A	ILE239
A	ALA240
A	ARG241
A	ASP265
A	HIS288
A	GLY290
A	SER291
A	GLV1336
A	HOH2059
A	HOH2078
A	VAL76
A	HOH2135
A	HOH2143
A	HOH2170
A	HOH2228
A	HOH2230
A	HOH2232
A	HOH2251
A	HOH2255
A	HOH2256
A	HOH2287
A	THR104
A	HOH2352
A	HOH2397
A	GLY157
A	PHE158
A	GLY159
A	ARG160
A	ILE161

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GLV A 1336

Chain	Residue
A	LEU53
A	ALA75
A	VAL76
A	GLY77
A	LEU100
A	ARG241
A	HIS288
A	NAP1335
A	HOH2352
A	HOH2353

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE A 1337

Chain	Residue
A	ARG56
A	ASP79
A	ASN80
A	ILE81
A	ASP82
A	HOH2398
A	HOH2399

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE 1PE A 1338

Chain	Residue
A	ARG133

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE A 1339

Chain	Residue
A	PHE294
A	1PE1347
A	HOH2401
A	HOH2403

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 1340

Chain	Residue
A	TYR220
A	ASN223
A	ARG226
A	HOH2295
A	HOH2404

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE A 1341

Chain	Residue
A	GLU13
A	TYR195

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE A 1342

Chain	Residue
A	ASN173
A	MET174
A	HOH2407

site_id	AC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1PE A 1343

Chain	Residue
A	THR115
A	ALA116
A	HIS118
A	LYS121
A	TYR146
A	ALA260
A	ASP281
A	ASN282
A	1PE1359
A	HOH2186
A	HOH2189
A	HOH2330

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 1344

Chain	Residue
A	PHE278
A	SER279
A	HOH2192
A	HOH2194
A	HOH2408

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE A 1345

Chain	Residue
A	LEU214
A	THR215
A	LYS216
A	HOH2046
A	HOH2290
A	HOH2409
A	HOH2410

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 1PE A 1346

Chain	Residue
A	TYR149
A	ARG167
A	1PE1347
A	HOH2180
A	HOH2412
A	HOH2413
A	ASP98
A	ASN102

site_id	BC4
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 1PE A 1347

Chain	Residue
A	TYR146
A	TYR149
A	LYS151
A	ASP206
A	THR233
A	1PE1339
A	1PE1346
A	HOH2220
A	HOH2221
A	HOH2223
A	HOH2285

site_id	BC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE A 1348

Chain	Residue
A	GLU199
A	GLU200
A	LYS203
A	LEU229

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE 1PE A 1349

Chain	Residue
A	MET219
A	TYR220
A	LYS243
A	GLU268
A	GLU269
A	HOH2400
A	HOH2416

site_id	BC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE EDO A 1350

Chain	Residue
A	GLU31
A	HIS139
A	TRP142
A	HOH2417

site_id	BC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE EDO A 1351

Chain	Residue
A	TYR220
A	ASP246

site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1352

Chain	Residue
A	GLY314

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO A 1353

Chain	Residue
A	LYS44
A	ASN64
A	PRO66
A	HOH2117
A	HOH2419

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO A 1354

Chain	Residue
A	LYS330
A	PRO331
A	GLY332
A	PHE333
A	ASN334
A	HOH2420

site_id	CC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE 1PE A 1355

Chain	Residue
A	TYR272
A	TYR273

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GLV A 1356

Chain	Residue
A	MET52
A	LEU53
A	TYR74
A	ALA75
A	TRP138
A	HOH2353

site_id	CC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 1357

Chain	Residue
A	LYS38
A	TYR78
A	ARG181
A	ACY1358
A	HOH2256
A	HOH2421

site_id	CC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ACY A 1358

Chain	Residue
A	ARG32
A	PRO35
A	ARG181
A	GLU217
A	ACY1357
A	HOH2287
A	HOH2292

site_id	CC7
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 1PE A 1359

Chain	Residue
A	HIS118
A	TRP142
A	PHE143
A	LEU144
A	TYR146
A	PHE294
A	1PE1343
A	HOH2076
A	HOH2185
A	HOH2214
A	HOH2219
A	HOH2422

Functional Information from PROSITE/UniProt

site_id	PS00065
Number of Residues	28
Details	D_2_HYDROXYACID_DH_1 D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. IGIVGfGRIGqaiarrakgfnmr.ILyYS

Chain	Residue	Details
A	ILE153-SER180

site_id	PS00671
Number of Residues	17
Details	D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKpTaILVNiARGkVVD

Chain	Residue	Details
A	MET230-ASP246

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255\|HAMAP-Rule:MF_00776

Chain	Residue	Details
A	ARG241
A	GLU270

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Proton donor => ECO:0000255\|HAMAP-Rule:MF_00776

Chain	Residue	Details
A	HIS288

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00776

Chain	Residue	Details
A	PHE158
A	SER180
A	ILE239
A	HIS288

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)