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5AOR

Structure of MLE RNA ADP AlF4 complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000228cellular_componentnuclear chromosome
A0000785cellular_componentchromatin
A0000805cellular_componentX chromosome
A0001069molecular_functionregulatory region RNA binding
A0003676molecular_functionnucleic acid binding
A0003678molecular_functionDNA helicase activity
A0003682molecular_functionchromatin binding
A0003690molecular_functiondouble-stranded DNA binding
A0003723molecular_functionRNA binding
A0003724molecular_functionRNA helicase activity
A0003725molecular_functiondouble-stranded RNA binding
A0004386molecular_functionhelicase activity
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005730cellular_componentnucleolus
A0005829cellular_componentcytosol
A0006325biological_processchromatin organization
A0008340biological_processdetermination of adult lifespan
A0009047biological_processdosage compensation by hyperactivation of X chromosome
A0016456cellular_componentX chromosome located dosage compensation complex, transcription activating
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0031453biological_processpositive regulation of heterochromatin formation
A0033679molecular_function3'-5' DNA/RNA helicase activity
A0034458molecular_function3'-5' RNA helicase activity
A0040029biological_processepigenetic regulation of gene expression
A0042714biological_processdosage compensation complex assembly
A0043138molecular_function3'-5' DNA helicase activity
A0045433biological_processmale courtship behavior, veined wing generated song production
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0048675biological_processaxon extension
A0050684biological_processregulation of mRNA processing
A0071168biological_processprotein localization to chromatin
A0072487cellular_componentMSL complex
A0106222molecular_functionlncRNA binding
A1990904cellular_componentribonucleoprotein complex
A2000765biological_processregulation of cytoplasmic translation
B0000166molecular_functionnucleotide binding
B0000228cellular_componentnuclear chromosome
B0000785cellular_componentchromatin
B0000805cellular_componentX chromosome
B0001069molecular_functionregulatory region RNA binding
B0003676molecular_functionnucleic acid binding
B0003678molecular_functionDNA helicase activity
B0003682molecular_functionchromatin binding
B0003690molecular_functiondouble-stranded DNA binding
B0003723molecular_functionRNA binding
B0003724molecular_functionRNA helicase activity
B0003725molecular_functiondouble-stranded RNA binding
B0004386molecular_functionhelicase activity
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0005730cellular_componentnucleolus
B0005829cellular_componentcytosol
B0006325biological_processchromatin organization
B0008340biological_processdetermination of adult lifespan
B0009047biological_processdosage compensation by hyperactivation of X chromosome
B0016456cellular_componentX chromosome located dosage compensation complex, transcription activating
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0031453biological_processpositive regulation of heterochromatin formation
B0033679molecular_function3'-5' DNA/RNA helicase activity
B0034458molecular_function3'-5' RNA helicase activity
B0040029biological_processepigenetic regulation of gene expression
B0042714biological_processdosage compensation complex assembly
B0043138molecular_function3'-5' DNA helicase activity
B0045433biological_processmale courtship behavior, veined wing generated song production
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0048675biological_processaxon extension
B0050684biological_processregulation of mRNA processing
B0071168biological_processprotein localization to chromatin
B0072487cellular_componentMSL complex
B0106222molecular_functionlncRNA binding
B1990904cellular_componentribonucleoprotein complex
B2000765biological_processregulation of cytoplasmic translation
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ADP A 2159
ChainResidue
AGLY410
AVAL772
AMG2160
AALF2161
AHOH3082
AHOH3084
AHOH3085
AHOH3181
AHOH3332
ACYS411
AGLY412
ALYS413
ATHR414
ATHR415
AARG452
ATHR725
AARG771

site_idAC2
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ADP B 2159
ChainResidue
BGLY410
BCYS411
BGLY412
BLYS413
BTHR414
BTHR415
BARG452
BTHR725
BARG771
BVAL772
BMG2160
BALF2161
BHOH3069
BHOH3081
BHOH3162
BHOH3166
BHOH3260

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG A 2160
ChainResidue
ATHR414
AASP507
AADP2159
AALF2161
AHOH3082
AHOH3083
AHOH3084

site_idAC4
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ALF A 2161
ChainResidue
ATHR409
AGLY410
ALYS413
AGLU508
ASER723
AARG768
AARG771
AADP2159
AMG2160
AHOH3082
AHOH3083
AHOH3084
AHOH3120
AHOH3121

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 2162
ChainResidue
AASP1099
AHOH3315
BGLU1133

site_idAC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MG B 2160
ChainResidue
BTHR414
BASP507
BADP2159
BALF2161
BHOH3069
BHOH3070
BHOH3071

site_idAC7
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ALF B 2161
ChainResidue
BTHR409
BGLY410
BLYS413
BGLU508
BSER723
BARG768
BARG771
BADP2159
BMG2160
BHOH3069
BHOH3070
BHOH3071
BHOH3093
BHOH3094

site_idAC8
Number of Residues5
DetailsBINDING SITE FOR RESIDUE GOL A 2163
ChainResidue
AGLU804
AGLU865
AHOH3228
AHOH3240
CU9

site_idAC9
Number of Residues2
DetailsBINDING SITE FOR RESIDUE GOL B 2162
ChainResidue
BGLN376
BPHE377

Functional Information from PROSITE/UniProt
site_idPS00690
Number of Residues10
DetailsDEAH_ATP_HELICASE DEAH-box subfamily ATP-dependent helicases signature. ShIIVDEIHE
ChainResidueDetails
ASER502-GLU511

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues144
DetailsDomain: {"description":"DRBM 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00266","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues332
DetailsDomain: {"description":"Helicase ATP-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00541","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues348
DetailsDomain: {"description":"Helicase C-terminal","evidences":[{"source":"PROSITE-ProRule","id":"PRU00542","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI4
Number of Residues6
DetailsMotif: {"description":"DEAH box"}
ChainResidueDetails

site_idSWS_FT_FI5
Number of Residues16
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5AOR","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

238895

PDB entries from 2025-07-16

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