5AOK
Structure of the p53 cancer mutant Y220C with bound small molecule PhiKan7099
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000976 | molecular_function | transcription cis-regulatory region binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005634 | cellular_component | nucleus |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0006915 | biological_process | apoptotic process |
| B | 0000976 | molecular_function | transcription cis-regulatory region binding |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005634 | cellular_component | nucleus |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0006915 | biological_process | apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 1291 |
| Chain | Residue |
| A | PRO219 |
| A | GLU221 |
| A | THR230 |
| A | THR231 |
| A | ILE232 |
| A | GOH1292 |
| A | HOH2212 |
| A | HOH2213 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1313 |
| Chain | Residue |
| A | HIS179 |
| A | CYS238 |
| A | CYS242 |
| A | CYS176 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE GOL B 1292 |
| Chain | Residue |
| B | PRO219 |
| B | CYS220 |
| B | GLU221 |
| B | THR230 |
| B | THR231 |
| B | ILE232 |
| B | GOH1294 |
| B | HOH2196 |
| B | HOH2197 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PEG B 1293 |
| Chain | Residue |
| B | HIS115 |
| B | SER116 |
| B | GLY117 |
| B | ARG282 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1300 |
| Chain | Residue |
| B | CYS176 |
| B | HIS179 |
| B | CYS238 |
| B | CYS242 |
| site_id | AC6 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GOH A 1292 |
| Chain | Residue |
| A | VAL147 |
| A | THR150 |
| A | PRO151 |
| A | CYS220 |
| A | GLU221 |
| A | PRO223 |
| A | THR230 |
| A | GOL1291 |
| A | HOH2094 |
| A | HOH2095 |
| A | HOH2107 |
| A | HOH2288 |
| site_id | AC7 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GOH B 1294 |
| Chain | Residue |
| B | VAL147 |
| B | THR150 |
| B | PRO151 |
| B | PRO152 |
| B | CYS220 |
| B | GLU221 |
| B | PRO223 |
| B | THR230 |
| B | GOL1292 |
| B | HOH2082 |
| B | HOH2083 |
| B | HOH2084 |
| B | HOH2097 |
| B | HOH2278 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 380 |
| Details | DNA_BIND: DNA_BIND => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | THR102-LYS292 | |
| B | THR102-LYS292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14534297, ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:17015838, ECO:0000269|PubMed:18650397, ECO:0000269|PubMed:19515728, ECO:0000269|PubMed:20142040, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | CYS176 | |
| A | HIS179 | |
| A | CYS238 | |
| A | CYS242 | |
| B | CYS176 | |
| B | HIS179 | |
| B | CYS238 | |
| B | CYS242 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Interaction with DNA => ECO:0000269|PubMed:16793544, ECO:0000269|PubMed:18996393, ECO:0000269|PubMed:20364130 |
| Chain | Residue | Details |
| A | LYS120 | |
| B | LYS120 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:17189187, ECO:0000269|PubMed:19854137, ECO:0000269|PubMed:23431171 |
| Chain | Residue | Details |
| A | LYS120 | |
| B | LYS120 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | MOD_RES: Phosphoserine; by AURKB => ECO:0000269|PubMed:20959462 |
| Chain | Residue | Details |
| A | SER183 | |
| A | SER269 | |
| B | SER183 | |
| B | SER269 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine; by AURKB => ECO:0000269|PubMed:20959462 |
| Chain | Residue | Details |
| A | THR284 | |
| B | THR284 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:12724314 |
| Chain | Residue | Details |
| A | LYS305 | |
| B | LYS305 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:19536131 |
| Chain | Residue | Details |
| A | LYS291 | |
| A | LYS292 | |
| B | LYS291 | |
| B | LYS292 |
