Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

5AKC

MutS in complex with the N-terminal domain of MutL - crystal form 2

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000018	biological_process	regulation of DNA recombination
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006298	biological_process	mismatch repair
A	0006974	biological_process	DNA damage response
A	0008301	molecular_function	DNA binding, bending
A	0016887	molecular_function	ATP hydrolysis activity
A	0030983	molecular_function	mismatched DNA binding
A	0032136	molecular_function	adenine/cytosine mispair binding
A	0032300	cellular_component	mismatch repair complex
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
A	1990710	cellular_component	MutS complex
B	0000018	biological_process	regulation of DNA recombination
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006298	biological_process	mismatch repair
B	0006974	biological_process	DNA damage response
B	0008301	molecular_function	DNA binding, bending
B	0016887	molecular_function	ATP hydrolysis activity
B	0030983	molecular_function	mismatched DNA binding
B	0032136	molecular_function	adenine/cytosine mispair binding
B	0032300	cellular_component	mismatch repair complex
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	1990710	cellular_component	MutS complex
C	0005524	molecular_function	ATP binding
C	0006298	biological_process	mismatch repair
C	0016887	molecular_function	ATP hydrolysis activity
C	0030983	molecular_function	mismatched DNA binding
C	0032300	cellular_component	mismatch repair complex
C	0140664	molecular_function	ATP-dependent DNA damage sensor activity
D	0005524	molecular_function	ATP binding
D	0006298	biological_process	mismatch repair
D	0016887	molecular_function	ATP hydrolysis activity
D	0030983	molecular_function	mismatched DNA binding
D	0032300	cellular_component	mismatch repair complex
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0000018	biological_process	regulation of DNA recombination
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006298	biological_process	mismatch repair
E	0006974	biological_process	DNA damage response
E	0008301	molecular_function	DNA binding, bending
E	0016887	molecular_function	ATP hydrolysis activity
E	0030983	molecular_function	mismatched DNA binding
E	0032136	molecular_function	adenine/cytosine mispair binding
E	0032300	cellular_component	mismatch repair complex
E	0042802	molecular_function	identical protein binding
E	0043531	molecular_function	ADP binding
E	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	1990710	cellular_component	MutS complex
F	0000018	biological_process	regulation of DNA recombination
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005829	cellular_component	cytosol
F	0006281	biological_process	DNA repair
F	0006298	biological_process	mismatch repair
F	0006974	biological_process	DNA damage response
F	0008301	molecular_function	DNA binding, bending
F	0016887	molecular_function	ATP hydrolysis activity
F	0030983	molecular_function	mismatched DNA binding
F	0032136	molecular_function	adenine/cytosine mispair binding
F	0032300	cellular_component	mismatch repair complex
F	0042802	molecular_function	identical protein binding
F	0043531	molecular_function	ADP binding
F	0140664	molecular_function	ATP-dependent DNA damage sensor activity
F	1990710	cellular_component	MutS complex
G	0005524	molecular_function	ATP binding
G	0006298	biological_process	mismatch repair
G	0016887	molecular_function	ATP hydrolysis activity
G	0030983	molecular_function	mismatched DNA binding
G	0032300	cellular_component	mismatch repair complex
G	0140664	molecular_function	ATP-dependent DNA damage sensor activity
H	0005524	molecular_function	ATP binding
H	0006298	biological_process	mismatch repair
H	0016887	molecular_function	ATP hydrolysis activity
H	0030983	molecular_function	mismatched DNA binding
H	0032300	cellular_component	mismatch repair complex
H	0140664	molecular_function	ATP-dependent DNA damage sensor activity
I	0000018	biological_process	regulation of DNA recombination
I	0000166	molecular_function	nucleotide binding
I	0003677	molecular_function	DNA binding
I	0003684	molecular_function	damaged DNA binding
I	0005515	molecular_function	protein binding
I	0005524	molecular_function	ATP binding
I	0005829	cellular_component	cytosol
I	0006281	biological_process	DNA repair
I	0006298	biological_process	mismatch repair
I	0006974	biological_process	DNA damage response
I	0008301	molecular_function	DNA binding, bending
I	0016887	molecular_function	ATP hydrolysis activity
I	0030983	molecular_function	mismatched DNA binding
I	0032136	molecular_function	adenine/cytosine mispair binding
I	0032300	cellular_component	mismatch repair complex
I	0042802	molecular_function	identical protein binding
I	0043531	molecular_function	ADP binding
I	0140664	molecular_function	ATP-dependent DNA damage sensor activity
I	1990710	cellular_component	MutS complex
J	0000018	biological_process	regulation of DNA recombination
J	0000166	molecular_function	nucleotide binding
J	0003677	molecular_function	DNA binding
J	0003684	molecular_function	damaged DNA binding
J	0005515	molecular_function	protein binding
J	0005524	molecular_function	ATP binding
J	0005829	cellular_component	cytosol
J	0006281	biological_process	DNA repair
J	0006298	biological_process	mismatch repair
J	0006974	biological_process	DNA damage response
J	0008301	molecular_function	DNA binding, bending
J	0016887	molecular_function	ATP hydrolysis activity
J	0030983	molecular_function	mismatched DNA binding
J	0032136	molecular_function	adenine/cytosine mispair binding
J	0032300	cellular_component	mismatch repair complex
J	0042802	molecular_function	identical protein binding
J	0043531	molecular_function	ADP binding
J	0140664	molecular_function	ATP-dependent DNA damage sensor activity
J	1990710	cellular_component	MutS complex
K	0005524	molecular_function	ATP binding
K	0006298	biological_process	mismatch repair
K	0016887	molecular_function	ATP hydrolysis activity
K	0030983	molecular_function	mismatched DNA binding
K	0032300	cellular_component	mismatch repair complex
K	0140664	molecular_function	ATP-dependent DNA damage sensor activity
L	0005524	molecular_function	ATP binding
L	0006298	biological_process	mismatch repair
L	0016887	molecular_function	ATP hydrolysis activity
L	0030983	molecular_function	mismatched DNA binding
L	0032300	cellular_component	mismatch repair complex
L	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP A 1801

Chain	Residue
A	LEU592
A	SER621
A	THR622
A	GLU694
A	HIS760
B	PHE670
B	MET671
A	PHE596
A	ILE597
A	PRO615
A	ASN616
A	MET617
A	GLY618
A	GLY619
A	LYS620

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP B 1801

Chain	Residue
A	PHE670
A	MET671
B	LEU592
B	PHE596
B	ILE597
B	ASN616
B	MET617
B	GLY619
B	LYS620
B	SER621
B	THR622
B	GLU694
B	HIS760

site_id	AC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ANP E 1801

Chain	Residue
E	VAL588
E	PHE596
E	ILE597
E	ASN599
E	PRO615
E	ASN616
E	MET617
E	GLY618
E	GLY619
E	LYS620
E	SER621
E	THR622
E	GLU694
E	HIS760
F	PHE670
F	MET671

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP F 1801

Chain	Residue
E	PHE670
E	MET671
F	PHE596
F	ILE597
F	PRO615
F	ASN616
F	MET617
F	GLY619
F	LYS620
F	SER621
F	THR622
F	GLU694
F	HIS760

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ANP I 1801

Chain	Residue
I	PRO615
I	ASN616
I	MET617
I	GLY618
I	GLY619
I	LYS620
I	SER621
I	THR622
I	GLU694
I	HIS760
J	PHE670
J	MET671

site_id	AC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP J 1801

Chain	Residue
I	PHE670
I	MET671
J	VAL588
J	PHE596
J	ILE597
J	PRO615
J	ASN616
J	MET617
J	GLY618
J	GLY619
J	LYS620
J	SER621
J	THR622
J	GLU694
J	HIS760

Functional Information from PROSITE/UniProt

site_id	PS00058
Number of Residues	7
Details	DNA_MISMATCH_REPAIR_1 DNA mismatch repair proteins mutL / hexB / PMS1 signature. GFRGEAL

Chain	Residue	Details
C	GLY93-LEU99

site_id	PS00486
Number of Residues	17
Details	DNA_MISMATCH_REPAIR_2 DNA mismatch repair proteins mutS family signature. SLvLmDEIGRGTstydG

Chain	Residue	Details
A	SER688-GLY704

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY614
B	GLY614
E	GLY614
F	GLY614
I	GLY614
J	GLY614

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)