5AKB

MutS in complex with the N-terminal domain of MutL - crystal form 1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000018	biological_process	regulation of DNA recombination
A	0003677	molecular_function	DNA binding
A	0003684	molecular_function	damaged DNA binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005829	cellular_component	cytosol
A	0006281	biological_process	DNA repair
A	0006298	biological_process	mismatch repair
A	0006974	biological_process	DNA damage response
A	0008301	molecular_function	DNA binding, bending
A	0016887	molecular_function	ATP hydrolysis activity
A	0030983	molecular_function	mismatched DNA binding
A	0032136	molecular_function	adenine/cytosine mispair binding
A	0032300	cellular_component	mismatch repair complex
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0140664	molecular_function	ATP-dependent DNA damage sensor activity
A	1990710	cellular_component	MutS complex
B	0000018	biological_process	regulation of DNA recombination
B	0003677	molecular_function	DNA binding
B	0003684	molecular_function	damaged DNA binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005829	cellular_component	cytosol
B	0006281	biological_process	DNA repair
B	0006298	biological_process	mismatch repair
B	0006974	biological_process	DNA damage response
B	0008301	molecular_function	DNA binding, bending
B	0016887	molecular_function	ATP hydrolysis activity
B	0030983	molecular_function	mismatched DNA binding
B	0032136	molecular_function	adenine/cytosine mispair binding
B	0032300	cellular_component	mismatch repair complex
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding
B	0140664	molecular_function	ATP-dependent DNA damage sensor activity
B	1990710	cellular_component	MutS complex
C	0005524	molecular_function	ATP binding
C	0006298	biological_process	mismatch repair
C	0016887	molecular_function	ATP hydrolysis activity
C	0030983	molecular_function	mismatched DNA binding
C	0032300	cellular_component	mismatch repair complex
C	0140664	molecular_function	ATP-dependent DNA damage sensor activity
D	0005524	molecular_function	ATP binding
D	0006298	biological_process	mismatch repair
D	0016887	molecular_function	ATP hydrolysis activity
D	0030983	molecular_function	mismatched DNA binding
D	0032300	cellular_component	mismatch repair complex
D	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	0000018	biological_process	regulation of DNA recombination
E	0003677	molecular_function	DNA binding
E	0003684	molecular_function	damaged DNA binding
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005829	cellular_component	cytosol
E	0006281	biological_process	DNA repair
E	0006298	biological_process	mismatch repair
E	0006974	biological_process	DNA damage response
E	0008301	molecular_function	DNA binding, bending
E	0016887	molecular_function	ATP hydrolysis activity
E	0030983	molecular_function	mismatched DNA binding
E	0032136	molecular_function	adenine/cytosine mispair binding
E	0032300	cellular_component	mismatch repair complex
E	0042802	molecular_function	identical protein binding
E	0043531	molecular_function	ADP binding
E	0140664	molecular_function	ATP-dependent DNA damage sensor activity
E	1990710	cellular_component	MutS complex
F	0005524	molecular_function	ATP binding
F	0006298	biological_process	mismatch repair
F	0016887	molecular_function	ATP hydrolysis activity
F	0030983	molecular_function	mismatched DNA binding
F	0032300	cellular_component	mismatch repair complex
F	0140664	molecular_function	ATP-dependent DNA damage sensor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ANP A 1801

Chain	Residue
A	VAL588
A	LYS620
A	SER621
A	THR622
A	HIS760
B	PHE670
B	MET671
A	LEU592
A	PHE596
A	ILE597
A	PRO615
A	ASN616
A	MET617
A	GLY618
A	GLY619

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ANP B 1801

Chain	Residue
A	PHE670
A	MET671
B	VAL588
B	LEU592
B	PHE596
B	ILE597
B	ASN616
B	MET617
B	GLY619
B	LYS620
B	SER621
B	THR622
B	HIS760

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ANP E 1801

Chain	Residue
E	LEU592
E	PHE596
E	ILE597
E	PRO615
E	ASN616
E	MET617
E	GLY618
E	GLY619
E	LYS620
E	SER621
E	THR622
E	HIS760

---

Functional Information from PROSITE/UniProt

site_id	PS00058
Number of Residues	7
Details	DNA_MISMATCH_REPAIR_1 DNA mismatch repair proteins mutL / hexB / PMS1 signature. GFRGEAL

Chain	Residue	Details
C	GLY93-LEU99

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site_id	PS00486
Number of Residues	17
Details	DNA_MISMATCH_REPAIR_2 DNA mismatch repair proteins mutS family signature. SLvLmDEIGRGTstydG

Chain	Residue	Details
A	SER688-GLY704

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000255

Chain	Residue	Details
A	GLY614
B	GLY614
E	GLY614

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