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5AIE

Not4 ring domain in complex with Ubc4

Functional Information from GO Data
ChainGOidnamespacecontents
A0004842molecular_functionubiquitin-protein transferase activity
A0030014cellular_componentCCR4-NOT complex
B0000151cellular_componentubiquitin ligase complex
B0000209biological_processprotein polyubiquitination
B0004842molecular_functionubiquitin-protein transferase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0006511biological_processubiquitin-dependent protein catabolic process
B0016567biological_processprotein ubiquitination
B0016740molecular_functiontransferase activity
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031625molecular_functionubiquitin protein ligase binding
B0034605biological_processcellular response to heat
B0043130molecular_functionubiquitin binding
B0043162biological_processubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
B0061631molecular_functionubiquitin conjugating enzyme activity
B0070628molecular_functionproteasome binding
B0071629biological_processcytoplasm protein quality control by the ubiquitin-proteasome system
B0072344biological_processrescue of stalled ribosome
B0072671biological_processmitochondria-associated ubiquitin-dependent protein catabolic process
B1990116biological_processribosome-associated ubiquitin-dependent protein catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1083
ChainResidue
ACYS33
ACYS36
ACYS57
ACYS60

site_idAC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE ZN A 1084
ChainResidue
ACYS50
ACYS52
ACYS74
ACYS77

Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. YHPNInan.GnICLdiL
ChainResidueDetails
BTYR75-LEU90

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Glycyl thioester intermediate => ECO:0000255|PROSITE-ProRule:PRU00388
ChainResidueDetails
BCYS86

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956
ChainResidueDetails
BSER12

site_idSWS_FT_FI3
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047
ChainResidueDetails
BLYS91

226707

PDB entries from 2024-10-30

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